Pulmonary nocardiosis in a patient with idiopathic CD4 T‐lymphocytopenia

Jayaschandran, Vivek; Gjorgova-Gjeorgjievski, Sandra; Siddique, Haamid

doi:10.1002/rcr2.283

Cited by 11 publications

(5 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…infection is usually seen in these patients when CD4 + counts drop to 35 cells/µl (352). Consistently, two patients with CD4 + T cell lymphocytopenia that developed pulmonary and CNS nocardiosis have been reported (353,354). Similarly, dampened cellular immunity in patients treated with corticosteroids longterm also predisposes to nocardiosis (355).…”

Section: Treatment and Outcomesupporting

confidence: 56%

Isolated Nocardiosis, an Unrecognized Primary Immunodeficiency?

Martı́nez-Barricarte

2020

Front. Immunol.

View full text Add to dashboard Cite

Nocardiosis is an infectious disease caused by the gram-positive bacterium Nocardia spp. Although it is commonly accepted that exposure to Nocardia is almost universal, only a small fraction of exposed individuals develop the disease, while the vast majority remain healthy. Nocardiosis has been described as an "opportunistic" disease of immunocompromised patients, suggesting that exposure to the pathogen is necessary, but a host predisposition is also required. Interestingly, increasing numbers of nocardiosis cases in individuals without any detected risk factors, i.e., without overt immunodeficiency, are being reported. Furthermore, a growing body of evidence have shown that selective susceptibility to a specific pathogen can be caused by a primary immunodeficiency (PID). This raises the question of whether an undiagnosed PID may cause nocardiosis affecting otherwise healthy individuals. This review summarizes the specific clinical and microbiological characteristics of patients with isolated nocardiosis published during the past 30 years. Furthermore, it gives an overview of the known human immune mechanisms to fend off Nocardia spp. obtained from the study of PIDs and patients under immunomodulatory therapies.

show abstract

Section: Treatment and Outcomesupporting

confidence: 56%

Isolated Nocardiosis, an Unrecognized Primary Immunodeficiency?

Martı́nez-Barricarte

2020

Front. Immunol.

View full text Add to dashboard Cite

show abstract

“…Isolates from three genera, Candida, Trichophyton and Microsporum are known to cause infections and can be particularly problematic for immunocompromised individuals [51][52][53]. Most of the isolates that were identified, such as Nocardia, Rhodotorula, and Sporobolomyces, are generally safe, but may act as opportunistic pathogens in immunocompromised individuals [54][55][56]. Other isolates, such as Chlorociboria aeruginascens, Lycogala epidendrum, Chromelosporium fulva,…”

Section: Fungal Isolationmentioning

confidence: 99%