Pulmonary Mucosa-associated Lymphoid Tissue (MALT) Lymphoma in Sj&amp;ouml;gren's Syndrome Showing Only the LIP Pattern Radiologically

Watanabe, Yasutaka; Koyama, Shinichiro; Miwa, Chihiro; Okuda, Shinya; Kanai, Yoshihiko; Tetsuka, Kenji; Dobashi, Yoh; Kawabata, Yoshinori; Kanda, Yoshinobu; Endo, Shunsuke

doi:10.2169/internalmedicine.51.6242

Cited by 19 publications

(13 citation statements)

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“…Although hilar and mediastinal lymphadenopathy is not a prominent radiological finding, nodal involvement is documented on pathologic analysis in ,30% of cases. Highresolution computed tomography (HRCT) findings include: areas of alveolar consolidation more frequently centred on dilated bronchi, ground-glass attenuation, the presence of the ''halo sign'', peribronchovascular nodules, the ''tree-in-bud pattern'', peribronchovascular thickening and septal lines (table 3) [42][43][44]. Radiographic findings may remain unvaried for several years.…”

Section: Specific Entitiesmentioning

confidence: 99%

Lymphoproliferative lung disorders: clinicopathological aspects

Poletti¹,

Ravaglia²,

Tomassetti³

et al. 2013

European Respiratory Review

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Lymphoproliferative disorders are rarely observed as primary lesions in the lung, representing only 0.3% of all primary pulmonary malignancies, ,1% of all the cases of non-Hodgkin lymphoma and 3-4% of all the extra nodal manifestations of non-Hodgkin lymphoma. The earliest comprehensive studies of pulmonary lymphomas were those of SALTZSTEIN [1] and PAPIOANNOU and WATSON [2], which were published in the 1960s. These investigators made important observations: low-grade neoplasms were more frequent than higher grade lymphomas (reticulum cell sarcomas) and both tumours had better clinical outcomes than their nodal-based counterparts. The authors also concluded that the majority of neoplasms with a low-grade cytological appearance should be considered as reactive proliferations, introducing the term ''pseudolymphoma''. This hypothesis showed significant weak points and, approximately 20 years later, ADDIS et al. [3] concluded that ''most if not all the cases of pseudo-lymphoma can be classified, when re-evaluated, as malignant lymphoma''. Knowledge of these entities expanded rapidly after the advent of new investigative tools such as immunohistochemistry and molecular biology techniques. The World Health Organization (WHO) classification of lymphoid neoplasm recently emphasised the importance of clinical features [4]. Table 1 provides an overall classification of lymphoproliferative disorders, which are described as: reactive/nonneoplastic lymphoid lesions, malignant parenchymal lymphoproliferative lesions (primary or secondary) and post-transplant lymphoproliferative disorders. Pathological aspectsReactive pulmonary lymphoid diseases Three rare forms of benign hyperplasia of pulmonary lymphoid tissue, namely follicular bronchiolitis, pulmonary nodular lymphoid hyperplasia and lymphocytic interstitial pneumonia, are regarded as part of the spectrum of lymphoid hyperplasia of the bronchus-associated lymphoid tissue (table 1) [5,6]. Follicular bronchiolitis is characterised by lymphoid follicular hyperplasia, often with reactive germinal centres, in the walls of bronchioles with narrowing of the lumen. Pulmonary nodular lymphoid hyperplasia (pulmonary pseudo-lymphoma) is a distinct form of reactive lymphoid proliferation with links to the family of IgG4-related sclerosing diseases, characterised by a dense nodular infiltration of mature, polyclonal lymphocytes and plasma cells, which are well-circumscribed and mainly sub-pleural, with some dense fibrosis between

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Section: Specific Entitiesmentioning

confidence: 99%

Lymphoproliferative lung disorders: clinicopathological aspects

Poletti¹,

Ravaglia²,

Tomassetti³

et al. 2013

European Respiratory Review

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“…Symptoms are usually dyspnea or cough. The disease usually responds to treatment with corticosteroid, but it may be complicated by progressive pulmonary fibrosis or malignant lymphoproliferative disorders (12)(13)(14). The predominant abnormalities on HRCT evaluation are as follows: patchy ground-glass opacity, lung cysts scattered, interlobular septal thickening, fine reticular opacities and lymphonodes enlargement ( Figure 3).…”

Section: Lipmentioning

confidence: 99%

Differential diagnosis of cystic lung diseases

Nosenzo¹,

Ariozzi²,

Sverzellati³

2013

SOB

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SummaryA lung cyst is defined as a round parenchymal lucency or area of low attenuation with a thin wall. Although lymphangioleiomyomatosis (LAM) and Langerhans cell histiocytosis (LCH) are the most frequently encountered causes, the differential diagnosis for diseases characterised by diffuse lung cysts is broad ranging from isolated chest disorders to rare multisystem diseases. This article will illustrate and describe the spectrum of diseases associated with air cysts at high-resolution CT (HRCT), highlighting disorders in which the HRCT findings can be diagnostic.

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“…SS is a common autoimmune disorder characterized by the degeneration of exocrine glands, clinically presenting as eye and mouth dryness [2]. Patients with SS have high levels of immunoglobulin, anti-Ro/SSA, and anti-La/SSB.…”

Section: To the Editormentioning

confidence: 99%

“…The risk of NHL development in patients with SS is approximately 40-44 times greater than that in the general population [2]. Lymphomas that appear during the course of SS are usually localized extranodal low-grade B-cell NHL and the major histopathological type is mucosa-associated lymphoid tissue lymphoma [4].…”

Section: To the Editormentioning

confidence: 99%