Pulmonary mucosa-associated lymphoid tissue lymphoma: 18F-FDG PET/CT and CT findings in 28 patients

Albano, Domenico; Borghesi, Andrea; Bosio, Giovanni; Bertoli, Mattia; Maroldi, Roberto; Giubbini, Raffaele; Bertagna, Francesco

doi:10.1259/bjr.20170311

Cited by 44 publications

(55 citation statements)

References 45 publications

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“…However, 2 different patterns must be distinguished: interstitial lung disease, which was not associated with lymphoma, and focal or nodular lesions that were highly suggestive of lymphoma. These results are consistent with those observed in pulmonary MALT-type lymphomas, independently of primary SS, where pulmonary nodules and focal condensation are the most frequently observed patterns on PET-CT images (17).…”

Section: Discussionsupporting

confidence: 91%

Usefulness of ¹⁸F‐Labeled Fluorodeoxyglucose–Positron Emission Tomography for the Diagnosis of Lymphoma in Primary Sjögren's Syndrome

Keraen

Blanc

Besson

et al. 2019

Arthritis & Rheumatology

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Objective The usefulness of positron emission tomography–computed tomography (PET‐CT) with 18F‐labeled fluorodeoxyglucose (18F‐FDG) for the diagnosis of lymphoma in patients with primary Sjögren's syndrome (SS) is unclear, since the abnormalities it reveals may be due to systemic manifestations of SS. This study was undertaken to compare 18F‐FDG–PET‐CT in patients with primary SS with lymphoma and those without lymphoma in order to identify patterns associated with lymphoma. Methods A retrospective study was conducted in 2 centers and included patients who met the American College of Rheumatology/European League Against Rheumatism 2016 criteria for primary SS and had undergone PET‐CT. Two independent readers who were blinded with regard to lymphoma diagnosis analyzed PET‐CT scans. Abnormalities were compared between patients with and those without lymphoma. Results Of the 45 patients included, 15 had lymphoma. Compared to patients without lymphoma, the mean size (P = 0.048) and maximum standardized uptake value (SUVmax) (P = 0.001) of the parotid glands were higher in patients with lymphoma. FDG uptake in the lymph nodes was observed in 53.3% of the patients with lymphoma and 43.3% of the patients without lymphoma, with no difference in the number of sites, uptake pattern, or mean SUVmax. Focal pulmonary uptake (nodules or condensations) was observed in 5 of the patients with lymphoma (33.3%) but only 1 patient without lymphoma (3.3%) (P = 0.01). Having an SUVmax in the parotid gland of ≥4.7 and/or the presence of focal pulmonary lesions was highly suggestive of lymphoma (sensitivity 80%, specificity 83.3%). Conclusion Some systemic manifestations of primary SS (lymphadenopathy, pulmonary involvement, and salivary gland involvement) can be visualized by PET‐CT. Involvement of the lymph nodes and parotid glands is commonly observed with a similar frequency in SS patients with and those without lymphoma. An SUVmax in the parotid glands of ≥4.7 and/or the presence of focal lung lesions are associated with the diagnosis of lymphoma.

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Section: Discussionsupporting

confidence: 91%

Usefulness of ¹⁸F‐Labeled Fluorodeoxyglucose–Positron Emission Tomography for the Diagnosis of Lymphoma in Primary Sjögren's Syndrome

Keraen

Blanc

Besson

et al. 2019

Arthritis & Rheumatology

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“…19 The authors com- 6 In a study of 28 patients with pulmonary MALT lymphoma, the avidity was 92%. 22 The prognostic significance of PET/CT has been inconclusive in The fact that we found no association between E-PET/CT and OS may probably be due to the small number of events. Thus, we cannot conclude if there was an effect.…”

Section: Discussionmentioning

confidence: 72%

“…The median SUVmax of all MZL was 3, and specifically 3.1 for MALT lymphoma and 2.2 for SMZL . In a study of 28 patients with pulmonary MALT lymphoma, the avidity was 92% …”

Section: Discussionmentioning

confidence: 99%

FDG PET/CT as a diagnostic and prognostic tool for the evaluation of marginal zone lymphoma

Vaxman

Bernstine

Kleinstern

et al. 2019

Hematological Oncology

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We evaluated the role of 18‐fluoro‐2‐deoxy‐d‐glucose positron emission tomography ([18F] FDG‐PET) with computed tomography (CT) (PET/CT) as a diagnostic and prognostic tool in newly diagnosed marginal zone lymphoma (MZL) patients. This is a retrospective cohort study of patients with newly diagnosed MZL, treated with immunotherapy, chemotherapy regimens, surgery, or Helicobacter pylori eradication between 2008 and 2016 in a single tertiary center. Only patients who had a pretreatment PET/CT (P‐PET/CT) were included. P‐PET/CT, interim (I‐PET/CT), and end‐of‐treatment PET/CT (E‐PET/CT) studies were reviewed. P‐PET/CT results were reported using two methods of evaluation, qualitative and semi quantitative: visual assessment (VAS) and maximal standardized uptake value (SUVmax), and I‐PET and E‐PET results were reported by Deauville 5‐point score (DS) evaluation as well. Avidity of PET/CT was defined as abnormal uptake in any of these methods. The primary outcome was the prognostic role of P‐PET/CT, I‐PET/CT, and E‐PET/CT on progression‐free survival (PFS) and overall survival (OS). Data of 196 patients with MZL were identified, 110 of which had P‐PET/CT and were included in this analysis. Median age was 67 years (range 18‐93). The median follow‐up period was 63 months (range 3‐278). The median OS and PFS for the whole cohort were 63 (interquartile range 39‐85) and 60 (interquartile range 37‐76) months, respectively. The avidity of PET at baseline for the whole cohort was 70% (77/110 patients), for MALT lymphoma, 62.5% (40/64 patients), for NMZL, 76.4% (13/17 patients), and for SMZL, 82.7% (24/29 patients). When adjusted for IPI, sex, and comorbidities, positive E‐PET/CT was associated with reduced PFS with a hazard ratio (HR) of 3.4 (95% CI, 1.27‐9.14, P = 0.02). Positive E‐PET/CT did not correlate with OS. However, there were only three events. P‐PET/CT was not predictive of PFS or OS. Our study demonstrates that above 70% of MZL are FDG avid. Positive E‐PET/CT is a strong prognostic factor for PFS.

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“…Primary lung malignancies presenting as subsolid nodules usually represent in situ, minimally invasive or invasive adenocarcinoma with predominant lepidic growth [12]. Rarely, primitive pulmonary lymphomas may also exhibit a subsolid nodular pattern [13].…”

Section: Discussionmentioning

confidence: 99%

Two synchronous lung metastases from malignant melanoma: the same patient but different morphological patterns

Borghesi

Tironi

Michelini

et al. 2019

European Journal of Radiology Open

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Malignant melanoma is an aggressive cancer with a high metastatic potential. Among the multiple sites of metastatic disease, the lung is one of the most frequently involved sites. Typically, pulmonary metastases from malignant melanoma occur as solid nodules. Rarely, pulmonary involvement in metastatic melanoma occurs as subsolid nodules. The present article describes an unusual case of a patient with malignant melanoma that developed two synchronous pulmonary metastases with two different densities on CT images (one solid and the other subsolid) and different morphological patterns on histologic images. The radiologic-pathologic correlation of these two patterns of presentation was also reported.

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Pulmonary mucosa-associated lymphoid tissue lymphoma: 18F-FDG PET/CT and CT findings in 28 patients

Cited by 44 publications

References 45 publications

Usefulness of ¹⁸F‐Labeled Fluorodeoxyglucose–Positron Emission Tomography for the Diagnosis of Lymphoma in Primary Sjögren's Syndrome

Usefulness of ¹⁸F‐Labeled Fluorodeoxyglucose–Positron Emission Tomography for the Diagnosis of Lymphoma in Primary Sjögren's Syndrome

FDG PET/CT as a diagnostic and prognostic tool for the evaluation of marginal zone lymphoma

Two synchronous lung metastases from malignant melanoma: the same patient but different morphological patterns

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Pulmonary mucosa-associated lymphoid tissue lymphoma: 18F-FDG PET/CT and CT findings in 28 patients

Cited by 44 publications

References 45 publications

Usefulness of 18F‐Labeled Fluorodeoxyglucose–Positron Emission Tomography for the Diagnosis of Lymphoma in Primary Sjögren's Syndrome

Usefulness of 18F‐Labeled Fluorodeoxyglucose–Positron Emission Tomography for the Diagnosis of Lymphoma in Primary Sjögren's Syndrome

FDG PET/CT as a diagnostic and prognostic tool for the evaluation of marginal zone lymphoma

Two synchronous lung metastases from malignant melanoma: the same patient but different morphological patterns

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Usefulness of ¹⁸F‐Labeled Fluorodeoxyglucose–Positron Emission Tomography for the Diagnosis of Lymphoma in Primary Sjögren's Syndrome

Usefulness of ¹⁸F‐Labeled Fluorodeoxyglucose–Positron Emission Tomography for the Diagnosis of Lymphoma in Primary Sjögren's Syndrome