Pulmonary Mucormycosis in Chronic Lymphocytic Leukemia and Neutropenia

Abstract

Pulmonary mucormycosis is a rare life-threatening fungal infection associated with high mortality. We present the case of a 61-year-old man with history of chronic lymphocytic leukemia who presented with fever and cough, eventually diagnosed with pulmonary mucormycosis after right lung video-assisted thoracoscopic surgery. The patient was successfully treated with amphotericin B and right lung pneumonectomy; however, he later died from left lung pneumonia.

Cutaneous mucormycosis in a chronic lymphocytic leukemia patient on ibrutinib

“…Due to the growing number of fungal infections arising in patients with B-cell malignancies on ibrutinib, Chamilos et al and other infectious disease physicians pushed for publications of these cases beginning in 2017 [ 11 ]. A number of cases have since been published, including sinus, disseminated, abdominal, CNS, and thyroid manifestations, as well as cutaneous seeded from a distant focus of infection ( Table 1 ) [ [12] , [13] , [14] , [15] , [16] , [17] , [18] ]. To our knowledge, there are only two reported cases of cutaneous mucormycosis in patients on ibrutinib for CLL: one patient presenting with localized disease from accidental skin trauma and a second with disseminated skin involvement in the setting of a bullous pemphigoid flare [ 12 , 13 ].…”

Análisis patológico en un paciente inmunodeprimido con mucormicosis: presentación de caso

“…La mucormicosis pulmonar es la más prevalente, y alcanza una tasa de mortalidad de hasta el 76 % de casos la cual aumenta con la gravedad del estado de inmunosupresión [12][13][14] . La MROC las esporangiosporas inhaladas alcanzan los senos paranasales diseminándose luego a las órbitas, seno cavernoso y cavidad craneal [15][16][17] .…”