Pulmonary mucormycosis associated with medical marijuana use

Stone, Taylor; Henkle, Joseph; Prakash, Vidhya

doi:10.1016/j.rmcr.2019.01.008

Cited by 11 publications

(15 citation statements)

References 19 publications

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“…Case reports [66][67][68][69][70] describing the effect of smoking, vaping, or inhaling aerosolized contaminated marijuana demonstrate some of the graver risks to patients, especially those with leukemia, lymphoma, AIDS, or those with medical conditions requiring immune-suppressing therapies. However, the disease has also been noted in non-immunocompromised patients, albeit at a less frequent rate.…”

Section: Risks and Effects Of Consumption Of Contaminated Cannabismentioning

confidence: 99%

Scientific Prospects for Cannabis-Microbiome Research to Ensure Quality and Safety of Products

et al. 2020

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Cannabis legalization has occurred in several countries worldwide. Along with steadily growing research in Cannabis healthcare science, there is an increasing interest for scientific-based knowledge in plant microbiology and food science, with work connecting the plant microbiome and plant health to product quality across the value chain of cannabis. This review paper provides an overview of the state of knowledge and challenges in Cannabis science, and thereby identifies critical risk management and safety issues in order to capitalize on innovations while ensuring product quality control. It highlights scientific gap areas to steer future research, with an emphasis on plant-microbiome sciences committed to using cutting-edge technologies for more efficient Cannabis production and high-quality products intended for recreational, pharmaceutical, and medicinal use.

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Section: Risks and Effects Of Consumption Of Contaminated Cannabismentioning

confidence: 99%

Scientific Prospects for Cannabis-Microbiome Research to Ensure Quality and Safety of Products

et al. 2020

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“…following marijuana use. 16 For instance, a recent case study documented the case of a diabetic patient who passed away after getting diagnosed with pulmonary mucormycosis. 16 Further investigation revealed that he had begun smoking medical marijuana only 3 months before his diagnosis.…”

Section: Resultsmentioning

confidence: 99%

“… 16 For instance, a recent case study documented the case of a diabetic patient who passed away after getting diagnosed with pulmonary mucormycosis. 16 Further investigation revealed that he had begun smoking medical marijuana only 3 months before his diagnosis. It was hypothesized that the combination of poorly controlled diabetes and emphysema caused by extensive cigarette smoking made him more susceptible to acquire this fungal infection.…”

Section: Resultsmentioning

confidence: 99%

Marijuana: A systems-based primer of adverse effects associated with use and an overview of its therapeutic utility

et al. 2021

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Marijuana use is on the rise in the United States. By the end of 2019, 33 states have legalized marijuana use and marijuana byproduct use for medical purposes. However, marijuana use does not come without side effects. This manuscript reviews the increasing usage of marijuana and the different forms (natural and synthetic) that patients may use when presenting to clinicians. It also addresses the biochemical and behavioral changes observed with marijuana use, including the location and changes associated with cannabinoid receptors (abbreviated CB1 and CB2). These two topics lead into an extensive review of the side effects of marijuana use. This manuscript discusses gastrointestinal side-effects, such as Cannabinoid Hyperemesis Syndrome, pancreatitis, and hepatotoxicity. It also briefly reviews cardiovascular, neurologic, and pulmonary side effects. This article provides an overview of therapeutic effects of marijuana including the antiemetic effect, its medical utility as an appetite stimulant, and usefulness in cancer patients post-chemotherapy. A thorough social history pertaining to marijuana use is an important consideration for clinicians in patients presenting with a variety of symptoms, including those effecting the gastrointestinal, cardiovascular, pulmonary, or neurologic systems.

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“…CotH is a fungal spore coat protein present in Mucorales species and functions as a ligand that can bind to GRP78, facilitating angioinvasion. 3 , 4 Moreover, hyperglycemia and ketoacidosis act to suppress the innate immune system in addition to facilitating an optimal environment for fungal proliferation. 3 , 4 Gender – Incorrect.…”

mentioning

confidence: 99%

“…3 , 4 Moreover, hyperglycemia and ketoacidosis act to suppress the innate immune system in addition to facilitating an optimal environment for fungal proliferation. 3 , 4 Gender – Incorrect. Gender is not an independent risk factor for the development of mucormycosis.…”

mentioning

confidence: 99%