Pulmonary MRI contrast using Surface Quadrupolar Relaxation (SQUARE) of hyperpolarized 83Kr

Six, Joseph S.; Hughes‐Riley, Theodore; Lilburn, David M.L.; Dorkes, Alan C.; Stupic, Karl F.; Shaw, Dominick; Morris, Peter G.; Hall, Ian P.; Pavlovskaya, Galina E.; Meersmann, Thomas

doi:10.1016/j.mri.2013.08.007

Cited by 14 publications

(13 citation statements)

References 35 publications

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“…In recent years, hyperpolarized noble gas NMR and MRI have been demonstrated as powerful tools to image the air space and to evaluate pulmonary gas exchange function (9)(10)(11)(12)(13)(14)(15), because the nuclear spin polarizations of hyperpolarized noble gases exceed the thermal equilibrium levels by four to five orders of magnitude via the technique of spin exchange optical pumping (SEOP) (16). Among the noble gases isotopes that are generally used in SEOP, 3 He and 129 Xe are the most commonly used in hyperpolarized noble gas NMR and MRI because their nuclear spin quantum number is 1/2, and they have longer longitudinal relaxation times (T 1 ) (17)(18)(19).…”

Section: Introductionmentioning

confidence: 99%

Quantitative evaluation of radiation-induced lung injury with hyperpolarized xenon magnetic resonance

Zhang

Xitao

et al. 2015

Magn. Reson. Med.

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Section: Introductionmentioning

confidence: 99%

Quantitative evaluation of radiation-induced lung injury with hyperpolarized xenon magnetic resonance

Zhang

Xitao

et al. 2015

Magn. Reson. Med.

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“…[82] The rapid relaxation suffered by the quadrupolar isotopes ( 21 Ne, 83 Kr, and 131 Xe) presents a challenge for most HP NMR applications, although as pointed out by Meersmann and co-workers, the quadrupolar interaction also endows a unique sensitivity of HP 83 Kr to surface chemistry and local geometry that can be complementary to the information provided by 129 Xe chemical shift – a feature that can prove useful for probing porous materials, lung tissues, and other systems. [38, 69b, 83] …”

Section: Fundamentals Of Noble Gas Hyperpolarizationmentioning

confidence: 99%

NMR Hyperpolarization Techniques of Gases

Barskiy

Coffey

Nikolaou

et al. 2016

Chemistry A European J

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146

113

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Nuclear spin polarization can be significantly increased through the process of hyperpolarization, leading to an increase in the sensitivity of nuclear magnetic resonance (NMR) experiments by 4–8 orders of magnitude. Hyperpolarized gases, unlike liquids and solids, can be more readily separated and purified from the compounds used to mediate the hyperpolarization processes. These pure hyperpolarized gases enabled many novel MRI applications including the visualization of void spaces, imaging of lung function, and remote detection. Additionally, hyperpolarized gases can be dissolved in liquids and can be used as sensitive molecular probes and reporters. This mini-review covers the fundamentals of the preparation of hyperpolarized gases and focuses on selected applications of interest to biomedicine and materials science.

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“…There are also exciting drug discovery results on the Ras proteins. For example, staurosporines have been found to disrupt phosphatidylserine trafficking and to mis‐localize Ras proteins . Andrographolide derivatives have been found to inhibit the GDP/GTP nucleotide exchange and to abrogate oncogenic Ras function .…”

Section: Targeting Aberrant Signaling: Mutant Ras Protein Inhibitorsmentioning

confidence: 99%

Review structure‐ and dynamics‐based computational design of anticancer drugs

Lin

2015

Biopolymers

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Cancer is a class of highly complex diseases involving multiple genes and multiple cross-talks between signaling networks. Cancer cells may be developed from inherited defects or acquired damages of DNA. However, many cancers are resistant to treatment, and metastasis of cancers makes the disease even more intractable. Secondary malignancies are frequently observed after cancer chemotherapy. The call for more effective cancer therapy is obligatory. Using drug-cocktails that combine multiple anti-cancer agents working in different mechanisms has been a standard treatment of cancers to overcome the drug resistance problem. More recently, design of multiple ligands (may be more easily understood as "multiple target ligands"), i.e., single agents that target multiple biomolecules in a rational manner, receives increasing attention. For those who work on computational drug design, such tasks serve as new opportunities for achieving drugs with more effective pharmacological actions, in addition to designing compounds with better binding affinity, better selectivity, or to discovering compounds that can exert their actions allosterically. Some recent methodological developments on computational drug design are reviewed, and a few recent drug design efforts on a selected set of targets (topoisomerases, Ras proteins, protein kinases, and histone deacetylases) toward cancer treatment and cancer prevention are summarized.

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Pulmonary MRI contrast using Surface Quadrupolar Relaxation (SQUARE) of hyperpolarized 83Kr

Cited by 14 publications

References 35 publications

Quantitative evaluation of radiation-induced lung injury with hyperpolarized xenon magnetic resonance

Quantitative evaluation of radiation-induced lung injury with hyperpolarized xenon magnetic resonance

NMR Hyperpolarization Techniques of Gases

Review structure‐ and dynamics‐based computational design of anticancer drugs

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