2020
DOI: 10.21203/rs.3.rs-83149/v1
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Pulmonary Midkine Inhibition Ameliorates Sepsis Induced Lung Injury via ACE/Ang II Pathway

Abstract: BackgroundMidkine is a multi-functional molecule participating in a various key pathological process. We aimed to evaluate the change of midkine in sepsis and its association with pulmonary function, as well as the mechanism by which midkine induced lung injury in sepsis. MethodsThe peripheral blood sample of septic patients on admission was obtained and measured for midkine, angiotensin-converting enzyme and angiotensin II. Cecal ligation and puncture (CLP) mouse model was used, and adeno-associated virus (AA… Show more

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