Pulmonary metastasis of a papillary thyroid carcinoma and primary lung adenocarcinoma: two coincident carcinomas at the same location

Abstract

Tumor-to-tumor metastasis is a fairly rare phenomenon. The lung cancers are the most common donors, but are exceedingly rare as recipients. Here we report a case of a lung adenocarcinoma acting as the recipient of papillary thyroid carcinoma, with multiple spreading foci of the two cancers in the lung simultaneously. The morphology and immunohistochemisty (Napsin-A, Thyroglobulin) are very important in differential diagnosis of lung primary adenocarcinoma and metastatic papillary thyroid carcinoma.Virtual SlidesThe virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/2069496615891134

Tumour‐to‐tumour metastasis from papillary thyroid carcinoma with BRAF mutation to lung adenocarcinoma with EGFR mutation: the utility of mutation‐specific antibodies

“…In addition to our case, eight cases have been reported in which lung cancer was the recipient of tumour‐to‐tumour metastasis. In the present case and four of the previous cases, the donor tumour was papillary thyroid carcinoma . Of the remaining four cases, breast carcinoma was the donor in two cases and maxillary sinus adenoid cystic carcinoma was the donor in two cases (Table ) .…”

“…In the present case and four of the previous cases, the donor tumour was papillary thyroid carcinoma . Of the remaining four cases, breast carcinoma was the donor in two cases and maxillary sinus adenoid cystic carcinoma was the donor in two cases (Table ) . The relatively low incidence of lung cancer as a recipient in tumour‐to‐tumour metastasis has been explained by differences in aggressiveness between the tumours …”

“…The incidence of cases in which lung cancer is the recipient is relatively low . To date, only eight cases of tumour‐to‐tumour metastasis into the lung have been reported in the English‐language literature …”

Dual malignancy in a thyroid; papillary thyroid carcinoma and small lymphocytic lymphoma; a report of a case with a cyto‐histologic correlation

“…9-11 Diagnosis of primary thyroid lymphoma using FNA has a reportedly high sensitivity and high positive predictive value. [18][19][20][21][22][23][24][25][26][27][28] Finding of PTC by FNA in this case was incidental while working the patient up for CLL/SLL, and we suspected thyroid involvement with SLL based on morphology and abundance of monomorphic lymphocytes in the smears. 13,14 Secondary lymphoma of thyroid gland is less common, and more likely to be found at autopsy.…”

Experience With Surgery for Synchronous Metastatic Lung Tumors From Colon and Thyroid Cancer

“…Coincidental occurrence of lung or mediastinal lymph node metastasis from occult thyroid cancer and "primary" lung cancer, and also collision tumor of the metastatic lung tumor from an adenoid cystic carcinoma and the "primary" lung cancer has been reported previously [2][3][4]. Another report has documented metachronous resection of lung metastases from cancers of the colon and kidney [5].…”