Pulmonary metastases (with admixed epithelial elements) from smooth muscle neoplasms

Wolff, Marianne; Kaye, Gordon I.; Silva, Fred

doi:10.1097/00000478-197908000-00004

Cited by 150 publications

(74 citation statements)

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“…Zu der Gruppe der nicht genau definier− ten Veränderungen zählen die diffuse Proliferation der glatten Muskulatur der Lunge, das Leiomyom bzw. Leiomyosarkom [7]. Bei unserer Patientin er− schienen die glatten Muskelzellen reif und es fand sich keine er− höhte Mitoserate, so dass ein Leiomyom bzw.…”

Section: Diskussionunclassified

Diffuse Proliferation der glatten Muskulatur der Lunge und schwere pulmonale Hypertonie

Halank

Ewert²,

Höffken³

et al. 2005

Pneumologie

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EinleitungDie diffuse Proliferation der glatten Muskulatur der Lunge (DSMPL) ist eine selten diagnostizierte Lungenerkrankung un− klarer Ätiologie. Sie ist gekennzeichnet durch eine diffuse Proli− feration der glatten Muskulatur unter Einbeziehung der Wände von Alveolen, Bronchien und pulmonalen Gefäßen. AbstractA 50−year old female forest worker presented with the com− plaints of progressive exercise induced dyspnea and the history of a recent syncope. Right heart catheterisation revealed the diagnosis of severe precapillary pulmonary hypertension. Venti− lation perfusion lung scan indicated the existence of multiple pulmonary emboli with high probability. However, pulmonary angiography did not confirm this finding. Computed tomography of the lung demonstrated a slight mosaic pattern of diffuse ground glass opacities. After video assisted thoracoscopy, the histologi− cal diagnosis of diffuse smooth muscle proliferation of the lung could be concluded from the removed lung tissue. Diffuse smooth muscle proliferation of the lung is a rarely diagnosed disease, however it should be considered in patients with sus− pected pulmonary embolism by ventilation perfusion scan but a normal finding in pulmonary angiography, who are suffering from otherwise not explained pulmonary hypertension. Kasuistik 867Dieses Dokument wurde zum persönlichen Gebrauch heruntergeladen. Vervielfältigung nur mit Zustimmung des Verlages.

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Section: Diskussionunclassified

Diffuse Proliferation der glatten Muskulatur der Lunge und schwere pulmonale Hypertonie

Halank

Ewert²,

Höffken³

et al. 2005

Pneumologie

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“…In addition, these retroperitoneal tumors can represent metastatic or synchronous primary lesions. Several hypotheses have been proposed to explain the metastasizing theory (the lungs are the most common site of metastatic involvement): (1) it could be a benign uterine tumor that spreads via a hematogenous route to the lungs or other organs [25], (2) it could be a surgically induced hematogenous spread, and the tumor would gain venous access from surgical trauma during hysterectomy [26], and (3) it could be a low-grade metastatic leiomyosarcoma [27]. Retroperitoneal tumors are sometimes seen on autopsy or are detected incidentally on routine checkup; so, they could also represent primary extrauterine leiomyomatosis unrelated to but coexisting with uterine leiomyomata [28].…”

Section: Discussionmentioning

confidence: 99%

Laparoscopic management of a pelvic retroperitoneal leiomyoma—case report

Kondo¹,

Botchorishvili²,

Desvignes³

et al. 2009

Gynecol Surg

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Leiomyomas are benign tumors frequently found in the fourth and fifth decades of life. Although the uterus is the most common site of origin of leiomyomas, they can develop at any site where there is smooth muscle cell. Extrauterine leiomyomas are not common and usually their diagnostic are more challenging. In this paper, we report one case of pelvic retroperitoneal leiomyoma associated to vulvar/perineal leiomyomas. A 47-year-old female patient presented with a 6-month history of deep dyspareunia, abdominal pain, dysuria, and pain during defecation. She had a previous history of two open myomectomies, a supracervical hysterectomy associated to the exeresis of a vulvar leiomyoma, and a left salpingo-oophorectomy. On vaginal examination, there was a tender and firm mass at the vaginal vault and along the posterior vaginal wall. There was another tumor at the left vulvar/perineal region measuring around 6 cm. Magnetic resonance imaging demonstrated the presence of a mass at the Douglas pouch measuring 14×10×10 cm suggestive of uterine leiomyomatosis. She underwent a successful laparoscopic resection of the pelvic tumor with an operative time of 210 min. The vulvar/perineal lesions were resected by vaginal approach. She presented an uneventful postoperative course and was discharged home 3 days after surgery. Histopathology confirmed the diagnosis of leiomyomas. Laparoscopic approach for pelvic retroperitoneal leiomyoma is feasible. It is important to keep in mind the possibility of this entity as a differential diagnosis of retroperitoneal masses in women.

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“…In general BML lesions have the same histological appearance as the initial uterine leiomyoma [4,12] . The histological differential diagnosis of pulmonary smooth muscle nodules includes BML, primary leiomyoma or leiomyosarcoma, metastatic leiomyosarcoma, pulmonary hamartoma, leiomyomatous hyperplasia and lymphangioleiomyomatosis [6,[13][14][15] , in which, however, the proliferating cells express HMB-45. Reported treatment methods include surgical resection of the nodules if possible, hysterectomy and bilateral oophorectomy, chemotherapy, progesterone and medical castration using luteinizing hormone-releasing analogue or the appropriate combination of them [2,8,16] .…”

Section: Discussionmentioning

confidence: 99%