Pulmonary metastases from intracranial meningioma

Mutnuru, Phani Chakravarty; Ahmed, Syed Fayaz; Uppin, Shantveer G; Lachi, Pavan Kumar

doi:10.4103/0970-2113.168120

Cited by 8 publications

(10 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Nevertheless, they were rarely reported with aggressive behavior and metastasis to regional or distant organs in various case reports. [4][5][6][7][8][9][10] Meningiomas with aggressive behavior would either directly invade the surrounding tissue, or disseminate mostly via hematogenous route, and less frequently via lymphatic and cerebrospinal fluid (CSF) pathways. [10][11][12][13] Intracranial meningiomas are expected for local invasion involving intracranial venous channels, bones, soft tissue and paranasal sinuses, in contrast to distant metastasis.…”

Section: Discussionmentioning

confidence: 99%

“…15 The common sites for distant metastasis are lungs (60%), pleura (9%) and mediastinum (5%). 10 Moreover, liver, lymph nodes, bones, peritoneum, scalp and orbita were reported for being metastasized by meningiomas. [4][5][6][7][8][9] Despite of case reports, the risk factors and metastasis pattern are quite unknown for intracranial meningiomas.…”

Section: Discussionmentioning

confidence: 99%

“…1 Although malign meningiomas tend to be metastatic more frequently, low grade meningiomas are not as uncommon as expected in extracranial metastasis. 1,10 Predisposing factors for metastasis from meningiomas have been previously described as high cellularity, cellular heterogeneity, high mitotic rate, nuclear pleomorphism and tumor necrosis which are also the histological criteria determining the predisposition to malignancy. 15,16 Other factors that may be related to extracranial spreading are indicated as repeated surgical resection of primary tumor, previous craniotomy, local recurrence and venous sinus invasion.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Metastatic Cavernous Sinus Meningioma: A Theory of Probable Predisposing Factor for Metastasis of Meningioma

Kurt¹,

Akmansu²,

Aslan³

2020

Turkiye Klinikleri J Case Rep

View full text Add to dashboard Cite

The majority of meningiomas are histologically benign (WHO grade I), however, they are rarely presented with metastasis, particularly in malign (WHO grade III) and atypical (WHO grade II) meningiomas. 1 Although there is little data in the literature regarding to the incidence of metastatic meningiomas, extracranial metastases have been reported as 0.1-0.7% in several case series. 2,3 According to the reviews of various case reports, anaplastic meningioma was the most frequent metastatic meningioma, followed by atypical and meningothelial subtypes. 1

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Metastatic Cavernous Sinus Meningioma: A Theory of Probable Predisposing Factor for Metastasis of Meningioma

Kurt¹,

Akmansu²,

Aslan³

2020

Turkiye Klinikleri J Case Rep

View full text Add to dashboard Cite

show abstract

“…Most are considered benign with good prognosis (WHO Grade I), while more uncommonly, they may be atypical (WHO Grade II) or anaplastic (WHO Grade III) meningiomas which are characterized by a more aggressive biological behavior and greater risk of recurrence and metastases. [ 3 4 ]…”

Section: Discussionmentioning

confidence: 99%

Extensive pulmonary metastases 13 years after initial resection of intracranial meningioma

et al. 2019

View full text Add to dashboard Cite

Background:Extracranial metastasis from intracranial meningioma is a very rare condition. A current literature review reveals that only few cases are documented with extensive pulmonary involvement >10 years after initial intracranial meningioma resection. Diagnosis of pulmonary meningioma is often confirmed by computed tomography chest-guided core biopsies. The prognosis of extensive metastatic pulmonary meningioma, however, is unknown and there is no gold standard treatment option.Case Description:We present a case of multiple pulmonary meningioma metastases developing 13 years after initial resection of left occipital parafalcine World Health Organization Grade I intracranial meningioma.Conclusion:There are no established guidelines for the optimal management or surveillance of extensive pulmonary metastatic meningioma. In patients with high-grade meningioma and multiple cannonball pulmonary lesions, metastatic meningioma should be considered as part of the differential diagnosis. Metastatic meningioma may occur even a decade after initial tumour resection.

show abstract

“…Malignant progression in meningiomas is low. Lungs (60%), pleura (9%), mediastinum (5%), liver, lymph nodes and bones are the most frequent site for distant metastasis (6).…”

Section: Introductionmentioning

confidence: 99%

Retrospective analysis of meningioma and alternative method of grading

Sayğın¹

2020

Erciyes Med J

View full text Add to dashboard Cite

Objective: The current classification of meningioma is based on the mitotic count, brain invasion and atypical histological changes. We re-evaluated the cases of meningioma to make accurate grading and to investigate the effects of morphological parameters and their relationship with each other. We discussed the counting method of mitotic activity. We tried to develop a novel method to determine the most accurate grade. Materials and Methods: In this study, three hundred nine cases of meningioma were re-evaluated. The number of mitosis in 10 consecutive high-power fields, as well as the total number of mitosis in 1 cm 2 area, was found for all cases. Receiver Operating Characteristics curve analysis was performed on the mitotic counts of 304 cases (grade I and II) in both 10 consecutive high-power fields and 1 cm 2 for predicting the grade. Results: In Receiver Operating Characteristics curve analysis, the number of mitoses determining grade II with 99% specificity and 84.4% sensitivity in 1 cm2 was 7 or more. Receiver Operating Characteristics curve analysis for the mitotic count in 10 consecutive high-power fields when the number of mitosis 4 or more, the sensitivity was 84.4%, and it was 100% specific for grade II. Conclusion: The major cause of the grade change was the number of mitotic activities. We recommend that the mitotic activity count in a large area. Especially, if there is 7 or more mitosis in 1 cm 2 , the case is to be high-grade. On the other hand, the presence of 1 or more mitosis in 42 high-power fields supports that this case is more likely to be grade II.

show abstract

Pulmonary metastases from intracranial meningioma

Cited by 8 publications

References 10 publications

Metastatic Cavernous Sinus Meningioma: A Theory of Probable Predisposing Factor for Metastasis of Meningioma

Metastatic Cavernous Sinus Meningioma: A Theory of Probable Predisposing Factor for Metastasis of Meningioma

Extensive pulmonary metastases 13 years after initial resection of intracranial meningioma

Retrospective analysis of meningioma and alternative method of grading

Contact Info

Product

Resources

About