Pulmonary metastases from ameloblastoma of the mandible treated with cisplatin, adriamycin, and cyclophosphamide

Ramadas, K; Jose, C.C.; John, Stanley; Chandi, Sushil M.; Viswanathan, Faith R.

doi:10.1002/1097-0142(19901001)66:7<1475::aid-cncr2820660707>3.0.co;2-d

Cited by 54 publications

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References 8 publications

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“…Since abnormal proliferation and growth of ameloblastoma cells easily destroys surrounding bony tissues, wide excision is required to treat this disorder. It is also reported that ameloblastomas rarely metastasize to other parts of the body, such as the lungs and regional lymph nodes (10,11). Associations of AMBN mutations were reported in ameloblastomas, adenomatoid odontogenic tumors, and squamous odontogenic tumors (12).…”

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confidence: 99%

Critical Role of Heparin Binding Domains of Ameloblastin for Dental Epithelium Cell Adhesion and Ameloblastoma Proliferation

Sonoda

Iwamoto

Nakamura

et al. 2009

Journal of Biological Chemistry

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AMBN (ameloblastin)is an enamel matrix protein that regulates cell adhesion, proliferation, and differentiation of ameloblasts. In AMBN-deficient mice, ameloblasts are detached from the enamel matrix, continue to proliferate, and form a multiple cell layer; often, odontogenic tumors develop in the maxilla with age. However, the mechanism of AMBN functions in these biological processes remains unclear. By using recombinant AMBN proteins, we found that AMBN had heparin binding domains at the C-terminal half and that these domains were critical for AMBN binding to dental epithelial cells. Overexpression of fulllength AMBN protein inhibited proliferation of human ameloblastoma AM-1 cells, but overexpression of heparin binding domain-deficient AMBN protein had no inhibitory effect. In full-length AMBN-overexpressing AM-1 cells, the expression of Msx2, which is involved in the dental epithelial progenitor phenotype, was decreased, whereas the expression of cell proliferation inhibitors p21 and p27 was increased. We also found that the expression of enamelin, a marker of differentiated ameloblasts, was induced, suggesting that AMBN promotes odontogenic tumor differentiation. Thus, our results suggest that AMBN promotes cell binding through the heparin binding sites and plays an important role in preventing odontogenic tumor development by suppressing cell proliferation and maintaining differentiation phenotype through Msx2, p21, and p27.The extracellular matrix provides structural support for cells and regulates cell proliferation, migration, differentiation, and apoptosis for tissue development and homeostasis (1). The extracellular matrix also plays a crucial role in pathological processes and diseases, such as wound healing, tumorigenesis, and cancer development (2, 3). AMBN (ameloblastin), also known as amelin and sheathlin, is a tooth-specific extracellular matrix and the most abundant non-amelogenin enamel matrix protein (4 -6). AMBN is expressed primarily by ameloblasts, which are differentiated from the oral ectoderm and form a polarized single cell layer underlying the enamel matrix. In a previous study, we created Ambn-null mice and demonstrated that AMBN is required for cell attachment and polarization and for maintaining the differentiation state of ameloblasts and is essential for enamel formation (3). Overexpression of Ambn in transgenic mice causes abnormal enamel crystallite formation and enamel rod morphology (7). These results suggest that enamel formation and rod morphology are influenced by temporal and spatial expressions of AMBN and imply that the AMBN gene locus may be involved in the etiology of a number of cases of undiagnosed hereditary amelogenesis imperfecta (8). Further, it was reported that recombinant AMBN enhances pulpal wound healing and reparative dentine formation following pulpotomy procedures, suggesting that it functions as a signal molecule in epithelial-mesenchymal interactions (9).We previously reported that about 20% of Ambn-null mice developed an odontogenic tumor of dental ep...

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mentioning

confidence: 99%

Critical Role of Heparin Binding Domains of Ameloblastin for Dental Epithelium Cell Adhesion and Ameloblastoma Proliferation

Sonoda

Iwamoto

Nakamura

et al. 2009

Journal of Biological Chemistry

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“…Another study noted partial response after 13 cycles of a combination of cisplatin and cyclophosphamide to treat lung metastases (11). Other drugs also had an effect (reducing the tumor size and alleviating symptoms), including vinblastine, bleomycin, paclitaxel, topotecan, and carboplatin (10,(15)(16)(17)(18). Based on the tumor spread in the current case and the desire for a more aggressive approach, a cisplatin-containing doublet as has been described in other studies (16,19) was chosen.…”

Section: Discussionmentioning

confidence: 99%

Rare case of ameloblastoma with pulmonary metastases

Valkadinov

Conev

Dzhenkov

et al. 2017

IRDR

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“…However, in the setting of metastatic disease, Ramadas found the use of cisplatin, adriamycin, and cyclophosphamide to be beneficial [13].…”

Section: Discussionmentioning

confidence: 99%

Ameloblastic carcinoma of the mandible: A case report and review of the literature

Abir

Abouchadi

Tourabi

et al. 2017

Med Buccale Chir Buccale

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-Aim:The purpose of this paper was to report an additional case of ameloblastic carcinoma of the left hemi-mandible and to review and analyze clinical, radiological and histopathologic features, treatment modalities and prognosis. Presentation of case: A 70 year old malepatient presented to Maxillofacial Department for a painful swelling of the left cheek. An ameloblastic carcinoma of the left hemi-mandible was diagnosed. He underwent radical surgical intervention comprising hemimandibulectomy, supraomohyoid neck dissection, and fibula free-flap reconstruction. Postoperative radiotherapy was employed. Discussion: Ameloblastic carcinoma of the mandible is a rare aggressive tumor with a poor prognosis. It can be seen in different ages. The most common symptom is a rapidly progressing painful swelling. It is defined as a malignant epithelial odontogenic tumor that retains the features of ameloblastic differentiation with cytologic features of malignancy. Non therapeutic consensus is established. However, wide surgical excision with radiotherapy is the most common treatment. Conclusion: Diagnosis of ameloblastic carcinoma at early stage and close periodic screening for metastasis are necessary to improve patient prognosis.

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Pulmonary metastases from ameloblastoma of the mandible treated with cisplatin, adriamycin, and cyclophosphamide

Cited by 54 publications

References 8 publications

Critical Role of Heparin Binding Domains of Ameloblastin for Dental Epithelium Cell Adhesion and Ameloblastoma Proliferation

Critical Role of Heparin Binding Domains of Ameloblastin for Dental Epithelium Cell Adhesion and Ameloblastoma Proliferation

Rare case of ameloblastoma with pulmonary metastases

Ameloblastic carcinoma of the mandible: A case report and review of the literature

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