Pulmonary masses: contrast enhancement.

Littleton, Jesse T.; Durizch, M L; Moeller, Gregor; Herbert, David

doi:10.1148/radiology.177.3.2244002

Cited by 58 publications

(42 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…A large interstitial space has been found in certain malignant tumors. Of note, in the washout phase from the interstitial space, a near absence or substantial reduction of lymphatic flow is noted in malignant tumors (22). The retarded flow in the intravascular and interstitial spaces is likely to contribute to the retention of contrast medium in malignant nodules.…”

Section: Discussionmentioning

confidence: 97%

See 1 more Smart Citation

Characterization of solitary pulmonary nodules: Use of washout characteristics at contrast-enhanced computed tomography

Zheng

et al. 2011

Oncology Letters

View full text Add to dashboard Cite

Abstract. The purpose of this study was to determine whether computed tomographic scans and attenuation measurements on contrast material-enhanced and non-enhanced computed tomographic scans could be used to characterize solitary pulmonary nodules and, in particular, to characterize these lesions using washout characteristics on contrast-enhanced computed tomography. A total of 63 patients (38 males, 25 females; age range, 21-80 years; mean age, 58±13.2 years) with pulmonary nodules revealed on contrast-enhanced computed tomography underwent 20-min delayed enhanced scans. The mean diameter of the pulmonary nodules was 1.8±0.6 cm (range, 0.8-2.9). Region-of-interest measurements were obtained at non-enhanced, dynamic enhanced and delayed enhanced computed tomography and were used to calculate a relative percentage washout as follows: 1 -(Hounsfield unit measurement on delayed image/Hounsfield unit measurement on dynamic image) x 100%. There was a mean relative washout of 33% on the delayed computed tomographic scans (range, 12-46) in benign solitary pulmonary nodules; and a mean relative washout of 7% (range, -36-51) in malignant solitary pulmonary nodules (Mann-Whitney U test, p<0.001). Results of the receiver operating curve analysis revealed that a threshold relative washout of 14.5% had 74.3% sensitivity and 92.9% specificity for identifying malignant nodules.Calculation of the relative percentage washout on dynamic and delayed enhanced computed tomographic scans may lead to a highly specific test for solitary pulmonary nodule characterization and reduce the need for, and possibly obviate, follow-up imaging or biopsy.

show abstract

Section: Discussionmentioning

confidence: 97%

“…The biological basis for the observed difference in washout characterization in malignant and benign pulmonary nodules can be postulated. Transduction of contrast medium through the lung involves the intravascular and interstitial spaces (22). A large interstitial space has been found in certain malignant tumors.…”

Section: Discussionmentioning

confidence: 99%

Characterization of solitary pulmonary nodules: Use of washout characteristics at contrast-enhanced computed tomography

Zheng

et al. 2011

Oncology Letters

View full text Add to dashboard Cite

show abstract

“…According to some studies, the malignant form of pulmonary lesions tends to expand substantially more than the benign form [26,27], and perfusion increases proportionally with size [28,29]. However, our technique of CT examination, performed to stage the lung masses, does not allow a specific evaluation of net enhancement.…”

Section: Discussionmentioning

confidence: 99%

Studio comparativo con esame TC contrastografico e con PET-TC del tumore polmonare non a piccole cellule

et al. 2013

View full text Add to dashboard Cite

BackgroundPersonalized cancer therapy remains a challenge. In this context, we attempted to identify correlations between tumour angiogenesis, tumour metabolism and tumour cell type. To this aim, we used single=phase multidetector computed tomography (MDCT) and hybrid positron emission tomography-computed tomography (PET/CT) to determine whether net enhancement and standardized uptake value (SUVmax) were correlated with tumour size and cytology in patients affected by non-small cell lung cancer (NSCLC).Material/MethodsOur study included 38 patients (30 men, 8 women, mean age 70) with a NSCLC measuring between 3 cm and 7 cm, using a 16-slice multidetector CT (Brilliance Philips) and with PET-CT (Biograph 16 Siemens Medical Solutions). The following lesion parameters were evaluated: maximum diameter, medium density before contrast injection (CTpre), medium density after contrast injection (CTpost average), density in the most enhanced part of the lesion after contrast (CTpost max), net enhancement, SUVmax, age, and cytology. Correlation coefficient and p-value were computed for each pair of variables. In addition, correlations were computed for each pair of variables, and for all combinations of tumour types. We focused on subsets of data with more than 10 observations, and with correlation r>0.500 and p<0.05.ResultsA weak correlation (r=0.32; p=0.048) was found between SUVmax and tumour size; the correlation was stronger for masses larger than 31 mm (r=0.4515; p=0.0268). No other correlations were found among the variables examined.ConclusionsOur data may have prognostic significance, and could lead to more appropriate surgical treatment and better treatment outcome.

show abstract

“…The report by Littleton et aí. 21 helps us to understand these phenomena as well as the mechanisms of TI-201 uptake by lung cancer. He discussed the mechanism of radio-contrast enhancement in malignant and benign pulmonary lesions from the standpoint of hemodynamics in the intravascular and interstitial compartments.…”

Section: Discussionmentioning

confidence: 99%

Single photon emission computed tomography using201Tl chloride in pulmonary nodules: Comparison with67Ga citrate and99mTc-labeled hexamethyl-propyleneamine-oxime

et al. 1992

View full text Add to dashboard Cite

A single photon emission computed tomography (SPECT) with 201Tl chloride (Tl-201) was carried out prospectively in 50 patients with pulmonary nodules and its diagnostic value was compared with those of 67Ga citrate (Ga-67) and 99mTc-labeled hexamethylpropyleneamine-oxime (Tc-99m-HMPAO). Tl-201 SPECT provided 88% (early)-91% (delayed) sensitivity, 85% (early and delayed) specificity and 87% (early)-89% (delayed) accuracy. The sensitivity of the Tl-201 planar image was 56 (early)-62% (delayed), which was significantly lower than that of SPECT. Delayed SPECT images at 2 hour postinjection were more preferable to disclose the malignant pulmonary nodule than early SPECT images at 15 minutes postinjection. The application of SPECT with Ga-67 failed to improve the sensitivity of planar imaging for malignant pulmonary nodules. Tc-99m-HMPAO was concentrated in 62% of 13 patients with malignant pulmonary nodules, which was slightly higher than Ga-67 in 54% of 28 patients. In an analysis of the histologic types of lung cancer, the sensitivity of Tl-201 was not significantly different in all types. On the other hand, Ga-67 was positive only in 25% of 12 patients with adenocarcinoma. A combination of SPECT and Tl-201 is the best choice among routine scintigraphic techniques for depicting malignant pulmonary nodules. The Tl-201 SPECT image may play a complementary role in the characterization of pulmonary nodules which are revealed on a plain radiograph and computed tomography.

show abstract

Pulmonary masses: contrast enhancement.

Cited by 58 publications

References 0 publications

Characterization of solitary pulmonary nodules: Use of washout characteristics at contrast-enhanced computed tomography

Characterization of solitary pulmonary nodules: Use of washout characteristics at contrast-enhanced computed tomography

Studio comparativo con esame TC contrastografico e con PET-TC del tumore polmonare non a piccole cellule

Single photon emission computed tomography using201Tl chloride in pulmonary nodules: Comparison with67Ga citrate and99mTc-labeled hexamethyl-propyleneamine-oxime

Contact Info

Product

Resources

About