Pulmonary Manifestations of Systemic Lupus Erythematosus

Murin, Susan; Wiedemann, Herbert; Matthay, Richard A.

doi:10.1016/s0272-5231(05)70108-8

Cited by 119 publications

(58 citation statements)

References 146 publications

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“…As with SSc, proximal pulmonary artery enlargement due to pulmonary hypertension, as well as oesophageal abnormalities, are found in MCTD [176]. Pleural effusions and pleural thickening are also seen, which resembles SLE [154].…”

Section: Treatmentmentioning

confidence: 95%

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Pivotal clinical dilemmas in collagen vascular diseases associated with interstitial lung involvement

Antoniou¹,

Margaritopoulos²,

Economidou³

et al. 2009

European Respiratory Journal

143

119

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The connective tissue disorders (CTDs), also called collagen vascular diseases (CVDs), represent a heterogeneous group of immunologically mediated inflammatory disorders with a large variety of affected organs. Individuals with a CTD (rheumatoid arthritis, systemic lupus erythematosus, systemic sclerosis, Sjögren's syndrome, polymyositis/dermatomyositis and mixed connective tissue disease) are susceptible to respiratory involvement. When the lungs are affected, an increasing mortality and morbidity in CVDs occurs. Interstitial lung disease (ILD) is established as a clinical corollary across the spectrum of CTDs, with an overall incidence estimated at 15%.Therefore, pivotal clinical dilemmas remain in the evaluation and management of ILD involvement in CVDs. Critical questions are the presence of fibrosis and whether the disease is clinically significant. Moreover, the clinician has to decide if treatment is warranted and which is the best therapeutic approach. The use of additional tests, such as pulmonary function tests, high-resolution computed tomography scan, bronchoalveolar lavage fluid and surgical lung biopsy, deserves better discussion. The present review focuses on establishing the diagnosis of ILD in CTD, and on evaluating disease activity and prognosis. This will provide the basis for therapeutic decisions that will be discussed, including an overview of recent advances.

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Section: Treatmentmentioning

confidence: 95%

“…Although lung involvement is not a criterion for SLE diagnosis, lung involvement has been associated with increased mortality [153,154].…”

Section: Clinical Featuresmentioning

confidence: 99%

Pivotal clinical dilemmas in collagen vascular diseases associated with interstitial lung involvement

Antoniou¹,

Margaritopoulos²,

Economidou³

et al. 2009

European Respiratory Journal

143

119

View full text Add to dashboard Cite

show abstract

“…[15][16][17][18] Murine SLE models also exhibit thoracic manifestations. 19 The MRL/MpJ-lpr mouse model carries the lymphoproliferation (lpr) mutation in the apoptosisrelated Fas gene, resulting in autoreactive lymphocyte proliferation.…”

Section: M M U N O L O G Y O R I G I N a L A R T I C L Ementioning

confidence: 99%

Comparative analysis of mediastinal fat‐associated lymphoid cluster development and lung cellular infiltration in murine autoimmune disease models and the corresponding normal control strains

2015

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SummaryWe previously discovered mediastinal fat-associated lymphoid clusters (MFALCs) as novel lymphoid clusters associated with mediastinal fat tissue in healthy mice. However, no data about their morphology in immune-associated disease conditions, and their relationship with lung infiltration, is available to date. In the present study, we compared the morphological features of MFALCs in 4-month-old male murine autoimmune disease models (MRL/MpJ-lpr mice and BXSB/MpJ-Yaa mice) with those of the corresponding control strains (MRL/MpJ and BXSB/MpJ, respectively). In addition, we analysed their correlation with lung infiltration. Furthermore, immunohistochemistry for CD3, B220, Iba1, Gr1 and BrdU was performed to detect T cells and B cells, macrophages, granulocytes and proliferating cells, respectively. The spleen weight to body weight ratios and anti-double-stranded DNA autoantibody titres were found to be significantly higher in the autoimmune models than in the control strains. Furthermore, the autoimmune model presented prominent MFALCs, with a significantly greater ratio of lymphoid cluster area to total mediastinal fat tissue area, and more apparent diffused cellular infiltration into the lung lobes than the other studied strains. Higher numbers of T and B cells, macrophages and proliferating cells, but fewer granulocytes, were observed in the autoimmune models than in the control strains. Interestingly, a significant positive Pearson's correlation between the size of the MFALCs and the density of CD3-, B220-and Iba1-positive cells in the lung was observed. Therefore, our data suggest a potentially important role for MFALCs in the progression of lung disease. However, further investigation is required to clarify the pathological role of MFALCs in lung disease, especially in inflammatory disorders.

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“…ALP is relatively uncommon, occurring in 1-12% of patients with SLE (19 -23). The clinical presentation includes cough, pleurisy, dyspnea, hypoxia, and patchy infiltrates, often with bilateral consolidations that resemble "bronchopneumonia" (20,21,23). Given the indistinguishable clinical and radiographic presentation from infectious etiologies of pneumonia, establishing the diagnosis requires ruling out infectious processes, often necessitating bronchoscopy.…”

Section: Acute Lupus Pneumonitis (Alp)mentioning

confidence: 99%

Two Systemic Lupus Erythematosus Patients With Severe Pleurisy: Similar Presentations, Different Causes

Gulati

Satlin

Magro

et al. 2013

Arthritis Care & Research

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Pulmonary Manifestations of Systemic Lupus Erythematosus

Cited by 119 publications

References 146 publications

Pivotal clinical dilemmas in collagen vascular diseases associated with interstitial lung involvement

Pivotal clinical dilemmas in collagen vascular diseases associated with interstitial lung involvement

Comparative analysis of mediastinal fat‐associated lymphoid cluster development and lung cellular infiltration in murine autoimmune disease models and the corresponding normal control strains

Two Systemic Lupus Erythematosus Patients With Severe Pleurisy: Similar Presentations, Different Causes

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