Pulmonary Magnetic Resonance Imaging of Ex-Preterm Children with and without Bronchopulmonary Dysplasia

Katz, Sherri L.; Párraga, Grace; Luu, Thuy Mai; Santyr, Giles; Abdeen, Nishard; Deschênes, Sylvain; Tse, Sze Man; Couch, Marcus J.; Barrowman, Nicholas; Hayawi, Lamia; Momoli, Franco; Blinder, Henrietta; Thébaud, Bernard; Nuyt, Anne‐Monique; Fadel, Nadya Ben; Moraes, Theo J.

doi:10.1513/annalsats.202106-691oc

Cited by 8 publications

(16 citation statements)

References 51 publications

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“…Our study found that both lower daily step count and lower MVPA were correlated with diminished proton density at full expiration on MRI, a measure of gas trapping. In our previous PICTURE study, diminished MRI proton density at full expiration was correlated with PFT measures suggestive of gas trapping (higher RV/TLC and lower FEV1) 13 , which have been shown to be associated with impaired exercise capacity in a previous study 34 . As pulmonary MRI measures may provide different and useful information compared to a clinical BPD diagnosis, further research is needed to understand factors that determine physical activity in this population 13 .…”

Section: Discussionmentioning

confidence: 71%

“…In our previous PICTURE study, diminished MRI proton density at full expiration was correlated with PFT measures suggestive of gas trapping (higher RV/TLC and lower FEV1) 13 , which have been shown to be associated with impaired exercise capacity in a previous study 34 . As pulmonary MRI measures may provide different and useful information compared to a clinical BPD diagnosis, further research is needed to understand factors that determine physical activity in this population 13 . Nonetheless, it was encouraging that the average number of steps taken by this cohort was significantly higher than expected when compared to CanPlay normative data for average step counts (11500-12200, depending on gender) in this age group 35 .…”

Section: Discussionmentioning

confidence: 71%

“…This study was performed in conjunction with the PICTURE study (Pulmonary Magnetic Resonance Imaging of Ex-preterm Children with and without Bronchopulmonary Dysplasia to Understand Risk of Emphysematous Changes; clinicaltrials.gov: NCT02921308) 13 . The PICTURE study is a multicentre, cross-sectional study which aimed to evaluate the use of ultra-short echo time MRI to assess lung structure in children born extremely preterm with and without BPD.…”

Section: Study Design and Settingmentioning

confidence: 99%

“…Children were identified from local neonatal follow-up databases at the respective study sites and consent/assent was obtained by the research coordinator. Children were eligible if they were 7-9 years of age and born at less than 28 weeks' gestation, with and without history of BPD, and were enrolled in the PIC-TURE study 13 . Participants were ineligible if they had 1) known lung anomalies or genetic conditions which may affect pulmonary function or MRI findings 2) contraindications for MRI, 3) any severe neurosensory impairment which might prevent test completion, or 4) a recent bacterial/viral respiratory illness (within the preceding 6 weeks) 13 .…”

Section: Participantsmentioning

confidence: 99%

“…Pulmonary MRI: Participants underwent a lung MRI to assess for average total proton density (at a lung volume of functional residual capacity plus one litre), which is a marker of lung tissue inhomogeneity, and average proton density at full expiration, which is an exploratory surrogate measure of gas trapping 13,20 . Novel research has identified correlations between pulmonary function and proton density, [21][22][23] but MRI measures provide different information about lung architecture 13 .…”

Section: Physical Activity Questionnaire (Paq)mentioning

confidence: 99%

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Physical activity level in children born extremely preterm: a comparison between children with and without bronchopulmonary dysplasia

Roeper

Blinder

Hayawi

et al. 2022

Preprint

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Introduction: Children with a history of bronchopulmonary dysplasia (BPD) may have lower physical activity levels, but evidence to date is based on self-report. This study compared physical activity levels between children born extremely preterm with and without history of BPD, and examined their associations with pulmonary magnetic resonance imaging (MRI) and pulmonary function test (PFT) indices. Methods: This multi-centre cross-sectional study included children aged 7-9 years born extremely preterm, with and without BPD. Children wore a pedometer for one week, then completed the Physical Activity Questionnaire (PAQ), pulmonary MRI, and PFT. Spearman correlations and multivariable linear regression modelling were performed. Results: Of 45 children, 28 had a history of moderate-severe BPD. There were no differences in any physical activity outcomes by BPD status. Higher average daily step count and higher average daily moderate-vigorous physical activity (MVPA) were each correlated with greater forced vital capacity (r=0.41 and 0.58), greater MRI lung proton density at full expiration (r=0.42 and 0.49), and lower lung clearance index (r=-0.50 and -0.41). After adjusting for MRI total proton density and BPD status, a 5% increase in forced expiratory volume at one second was associated with 738 (95%CI: 208, 1268) more steps per day and 0.1 (0.0, 0.2) more hours of MVPA, respectively. Conclusion: School-aged children born extremely preterm have similar physical activity levels to their peers, regardless of history of BPD. MRI and PFT measures suggestive of gas trapping and/or airflow obstruction are associated with lower physical activity levels.

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Section: Discussionmentioning

confidence: 71%

Section: Discussionmentioning

confidence: 71%

Section: Study Design and Settingmentioning

confidence: 99%

Section: Participantsmentioning

confidence: 99%

Section: Physical Activity Questionnaire (Paq)mentioning

confidence: 99%

See 3 more Smart Citations

Physical activity level in children born extremely preterm: a comparison between children with and without bronchopulmonary dysplasia

Roeper

Blinder

Hayawi

et al. 2022

Preprint

Self Cite

View full text Add to dashboard Cite

show abstract

Physical activity levels, pulmonary function, and MRI in children born extremely preterm: A comparison between children with and without bronchopulmonary dysplasia

Roeper

Blinder

Hayawi

et al. 2023

Pediatric Pulmonology

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Introduction: Children with a history of bronchopulmonary dysplasia (BPD) may have lower physical activity levels, but evidence to date is mixed. This study compared physical activity levels between children born extremely preterm with and without history of BPD, and examined their associations with pulmonary magnetic resonance imaging (MRI) and pulmonary function test (PFT) indices.Methods: This multicentre cross-sectional study included children aged 7-9 years born extremely preterm, with and without BPD. Children wore a pedometer for 1 week, then completed the Physical Activity Questionnaire (PAQ), pulmonary MRI, and PFT. Spearman correlations and multivariable linear regression modeling were performed.Results: Of 45 children, 28 had a history of moderate-severe BPD. There were no differences in any physical activity outcomes by BPD status. Higher average daily step count and higher average daily moderate-to-vigorous physical activity (MVPA) were each correlated with greater forced vital capacity (r = 0.41 and 0.58), greater MRI lung proton density at full expiration (r = 0.42 and 0.49), and lower lung clearance index (r = −0.50 and −0.41). After adjusting for MRI total proton density and BPD status, a 5% increase in forced expiratory volume at 1 s was associated with 738 (95% CI: 208, 1268) more steps per day and 0.1 (0.0, 0.2) more hours of MVPA, respectively.

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2022 Year in review: Neonatal pulmonology

Ryan

Auten

2023

Pediatric Pulmonology

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Pulmonary Magnetic Resonance Imaging of Ex-Preterm Children with and without Bronchopulmonary Dysplasia

Cited by 8 publications

References 51 publications

Physical activity level in children born extremely preterm: a comparison between children with and without bronchopulmonary dysplasia

Physical activity level in children born extremely preterm: a comparison between children with and without bronchopulmonary dysplasia

Physical activity levels, pulmonary function, and MRI in children born extremely preterm: A comparison between children with and without bronchopulmonary dysplasia

2022 Year in review: Neonatal pulmonology

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