Pulmonary lymphoproliferative diseases

Addis, B. J.

doi:10.1017/cbo9781139018760.037

Cited by 1 publication

(3 citation statements)

References 513 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Clinical features associated with poor prognosis in a study of primary pulmonary lymphoma included patients .60 years of age with elevated serum LDH and elevated serum b 2 -microglobulin levels [37,47]. High-grade primary large pulmonary B-cell lymphomas often occur in patients with underlying immunological disorders such as immunosuppression in solid organ transplantation, HIV infection and Sjögren syndrome [17,48]. Patients are usually symptomatic with respiratory symptoms (cough, dyspnoea and haemoptysis), fever and weight loss.…”

Section: Specific Entitiesmentioning

confidence: 99%

“…Lymphomatoid granulomatosis may affect virtually any organ, it is most frequently characterised by pulmonary, skin and central nervous system involvement. This condition usually affect adults (average age 50 years) with a predilection for males (male to female ratio 2:1) and patients with underlying immunodeficiency (HIV positive patients and Wiskott-Aldrich syndrome) [48]. However, occurrence in childhood has been documented.…”

Section: Specific Entitiesmentioning

confidence: 99%

“…When less invasive procedures fail (mostly in non-MALT lymphomas), a definitive diagnosis can be obtained from surgical samples (mostly by video-assisted thoracoscopy and less so by open lung thoracotomy). Immunohistochemical analysis is mandatory in diagnosing all types of pulmonary lymphomas [4,48]. Neoplastic lymphocytes are characterised by distinct molecular profiles useful to distinguish pulmonary MALT lymphoma from reactive processes and other lymphomas.…”

Section: Diagnosis and Staging Of Lymphoproliferative Lung Disordersmentioning

confidence: 99%

See 2 more Smart Citations

Lymphoproliferative lung disorders: clinicopathological aspects

Poletti¹,

Ravaglia²,

Tomassetti³

et al. 2013

European Respiratory Review

View full text Add to dashboard Cite

Lymphoproliferative disorders are rarely observed as primary lesions in the lung, representing only 0.3% of all primary pulmonary malignancies, ,1% of all the cases of non-Hodgkin lymphoma and 3-4% of all the extra nodal manifestations of non-Hodgkin lymphoma. The earliest comprehensive studies of pulmonary lymphomas were those of SALTZSTEIN [1] and PAPIOANNOU and WATSON [2], which were published in the 1960s. These investigators made important observations: low-grade neoplasms were more frequent than higher grade lymphomas (reticulum cell sarcomas) and both tumours had better clinical outcomes than their nodal-based counterparts. The authors also concluded that the majority of neoplasms with a low-grade cytological appearance should be considered as reactive proliferations, introducing the term ''pseudolymphoma''. This hypothesis showed significant weak points and, approximately 20 years later, ADDIS et al. [3] concluded that ''most if not all the cases of pseudo-lymphoma can be classified, when re-evaluated, as malignant lymphoma''. Knowledge of these entities expanded rapidly after the advent of new investigative tools such as immunohistochemistry and molecular biology techniques. The World Health Organization (WHO) classification of lymphoid neoplasm recently emphasised the importance of clinical features [4]. Table 1 provides an overall classification of lymphoproliferative disorders, which are described as: reactive/nonneoplastic lymphoid lesions, malignant parenchymal lymphoproliferative lesions (primary or secondary) and post-transplant lymphoproliferative disorders. Pathological aspectsReactive pulmonary lymphoid diseases Three rare forms of benign hyperplasia of pulmonary lymphoid tissue, namely follicular bronchiolitis, pulmonary nodular lymphoid hyperplasia and lymphocytic interstitial pneumonia, are regarded as part of the spectrum of lymphoid hyperplasia of the bronchus-associated lymphoid tissue (table 1) [5,6]. Follicular bronchiolitis is characterised by lymphoid follicular hyperplasia, often with reactive germinal centres, in the walls of bronchioles with narrowing of the lumen. Pulmonary nodular lymphoid hyperplasia (pulmonary pseudo-lymphoma) is a distinct form of reactive lymphoid proliferation with links to the family of IgG4-related sclerosing diseases, characterised by a dense nodular infiltration of mature, polyclonal lymphocytes and plasma cells, which are well-circumscribed and mainly sub-pleural, with some dense fibrosis between

show abstract

Section: Specific Entitiesmentioning

confidence: 99%

Section: Specific Entitiesmentioning

confidence: 99%

Section: Diagnosis and Staging Of Lymphoproliferative Lung Disordersmentioning

confidence: 99%

See 1 more Smart Citation