Pulmonary lymphangitic carcinomatosis from squamous cell carcinoma of the cervix

Abstract

IntroductionPulmonary metastasis presenting as lymphangitic carcinomatosis arising from squamous cell carcinoma (SCC) of the cervix is a rare event. Poorly represented in the literature, this event is associated with a) difficulty in accurate diagnosis, b) grave prognosis, and the c) lack of recognized predisposing risk factors.Case ReportA 50 year-old female presented at our practice with a three-month history of a productive cough associated with dyspnoea and shortness of breath. A chest x-ray and computed tomography (CT) scan revealed multiple bilateral patchy areas with subsegmental atelectasis in both lungs which was investigated with a bronchoscopy, left thoracoscopy, and a left lung biopsy. Pathological examination of the wedge biopsy of the left upper lobe revealed neoplastic sheets of cell disturbed along the septal vessels, perivascular/peribronchial lymphatics, and the subpleural lymphatics. This lymphangitic carcinomatosis was confirmed to be metastatic from SCC of the cervix that had been diagnosed and treated two years ago. She was treated with systemic Carbo/Taxol chemotherapy and corticosteroids as a palliative measure. Despite temporary improvement, she died 13 months later.ConclusionPulmonary lymphangitic carcinomatosis is a rare manifestation of metastatic SCC of the cervix. As clinical presentations including radiographic imaging mimics other pulmonary entities, accurate diagnosis remains a challenge. Increased clinical awareness of such patterns of metastases in cervical cancer supported by accurate pathological diagnosis is imperative to guide appropriate therapy in these patients.

Alpha-mangostin induces apoptosis through activation of reactive oxygen species and ASK1/p38 signaling pathway in cervical cancer cells

“…The incidence rate of cervical cancer has decreased by 3.0% per year in women older than 50-years; however, the rate remains stable in women younger than 50-years [ 2 ]. The critical factors influencing mortality in cervical cancer patients are recurrence and metastasis to other sites, including lymph nodes [ 3 ], lungs [ 4 , 5 ], and liver [ 6 ]. Clinical trials have shown that systemic treatments such as chemotherapy, and combination therapy with chemotherapeutic drugs and angiogenesis blockade prolong overall and progression-free survival of cervical cancer patients with recurrence or metastasis [ 7 ].…”

Differential Proteomic Analysis Reveals Protein Networks and Pathways that May Contribute to Helicobacter pylori FKBP‐Type PPIase‐Associated Gastric Diseases

“…Calpain1 modulates cell proliferation by regulating p27 (Kip1) degradation and transcription . PCNA participates in DNA replication, cell cycle regulation, DNA repair and the promotion of cell proliferation by stimulating the DNA polymerase δ activity, and interacting with p21 that is a regulatory factor of the cell cycle . PHB belongs to the Band‐7 family.…”

Pulmonary lymphangitic carcinomatosis in the course of gastric cancer – Case report

“…Evaluation of tissue samples collected during lung biopsy reveals interstitial oedema and fibrosis, together with neoplastic cells. Unfortunately, in most cases, such information is [15,16,17].…”