Pulmonary lymph node charting in normal dogs with blue dye and scintigraphic lymphatic mapping

Tuohy, Joanne; Worley, Deanna R.

doi:10.1016/j.rvsc.2014.07.002

Cited by 17 publications

(22 citation statements)

References 23 publications

(32 reference statements)

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“…In this case series, a minimum of 3 patients with metastatic disease would not have been identified had a LN biopsy not been performed based upon the LN size being noted as normal on CT imaging. Retrieval of intrathoracic lymph nodes, particularly the hilar and interlobar lymph nodes, is challenging even with understanding of canine anatomy yet critical for staging (29).…”

Section: Discussionmentioning

confidence: 99%

A Contemporary Retrospective Study of Survival in Dogs With Primary Lung Tumors: 40 Cases (2005–2017)

Rose

Worley

2020

Front. Vet. Sci.

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Patients were identified for inclusion if they had lung lobectomy and an intrathoracic lymph node biopsy performed. The median survival time (MST) for lymph node positive (LN+) and negative dogs (LN-) was calculated as well as the MST in dogs that did or did not receive adjuvant chemotherapy. Differences were compared between groups with significance set at p < 0.05. Results: The MST in LN+ dogs (n = 11) was 167 days which was not statistically different from LN-dogs (n = 29) at 456 days (p = 0.2407). No significant difference in the MST in LN+ dogs was identified between dogs that received adjuvant chemotherapy (n = 4; 110 days) and those that did not receive adjuvant chemotherapy (n = 6; 125 days) (p = 0.4409). There was no difference in survival time in LN-dogs receiving chemotherapy (n = 12; 335 days) as compared to those LN-dogs (n = 10) that did not receive adjuvant chemotherapy (258.5 days; p = 0.6475). Conclusions and Clinical Relevance: The survival of primary pulmonary neoplasia in dogs with intrathoracic nodal metastasis is longer than previously reported in this contemporary cohort. Chemotherapy did not appear to improve survival in LN+ or LNdogs. The combination of tumor size between 100 and 999 cm 3 and positive lymph node status significantly reduced survival.

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Section: Discussionmentioning

confidence: 99%

A Contemporary Retrospective Study of Survival in Dogs With Primary Lung Tumors: 40 Cases (2005–2017)

Rose

Worley

2020

Front. Vet. Sci.

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“…Radioactive tracer techniques are rather labor intense and not readily usable. However, they are described to work for certain tumor types and sites in animals as well . However, the involvement of radioactive substances with essential radiation safety drug and patient handling issues as well as cost of equipment presents a limitation for certain veterinary facilities.…”

Section: Discussionmentioning

confidence: 99%

“…However, they are described to work for certain tumor types and sites in animals as well. 4,9,14 However, the involvement of radioactive substances with essential radiation safety drug and patient handling issues as well as cost of equipment presents a limitation for certain veterinary facilities. Furthermore, the procedure is described to be a multidisciplinary approach and accuracy largely depends on the expertise of the specialists performing the procedure.…”

Section: Lymph Node Grouping and Assessmentmentioning

confidence: 99%

“…The use of noninvasive sentinel lymph node mapping techniques were strongly advocated in veterinary medicine, and in the last few years some studies combining lymphoscintigraphy and peritumoral injection of methylene blue dye have been published . Furthermore, contrast agent‐related techniques for lymph node identification useful in a clinical oncologic setting have been prior described experimentally and clinically in animals, including indirect lymphography and contrast ultrasound …”

Section: Introductionmentioning

confidence: 99%

“…13 The use of noninvasive sentinel lymph node mapping techniques were strongly advocated in veterinary medicine, 9 and in the last few years some studies combining lymphoscintigraphy and peritumoral injection of methylene blue dye have been published. 4,14 Furthermore, contrast agent-related techniques for lymph node identification useful in a clinical oncologic setting have been prior described experimentally and clinically in animals, including indirect lymphography and contrast ultrasound. [15][16][17][18][19][20] Normal dogs were initially used as a model to test the feasibility of mammary CT-lymphography for breast cancer in humans with good success and this technique has recently been shown to have a diagnostic value in the detection of metastasis in dogs with mammary tumors.…”

Section: Introductionmentioning

confidence: 99%

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Computed tomographic‐lymphography as a complementary technique for lymph node staging in dogs with malignant tumors of various sites

Rossi

Körner

Suarez

et al. 2017

Vet Radiology Ultrasound

112

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Locoregional lymph nodes are routinely examined in order to define the spatial extent of neoplastic disease. As draining patterns of certain tumor types can be divergent from expected anatomical distribution, it is critical to sample the lymph nodes truly representing the draining area. The aim of this bicenter prospective pilot study was to describe the technique of computed tomographic (CT)-lymphography for primary draining lymph node mapping in tumor staging in dogs. Forty-five dogs with macro- or microscopic tumors in specified localizations were evaluated. Depending on body weight, 0.8-2 ml contrast agent (iohexol) was injected into four quadrants around the tumor, and CT-images were obtained at 1, 3, 6, 9, and 12 minutes post-injection. Attenuation of chosen regions of interest (Hounsfield units (HU)) and patterns of enhancement were assessed for 284 lymph nodes in the precontrast study with median HUs of 31.1 (Interquartile range (IQR) = 18.4) and for 275 in the intravenous postcontrast study with 104.3 HU (IQR = 31.2) (paired Wilcoxon test, P < 0.001). In the CT-lymphography study, 45 primary draining lymph nodes with a significantly higher median HU value of 348.5 (IQR = 591.4) (one-sample t-test, P < 0.001) were identified. Primary draining lymph nodes were found to be clearly visible after 1-3 minutes after local injection, often concurrent with a good visibility of the lymphatic vessel system. The herein described technique of peritumorally injected CT-contrast agent followed by subsequent CT-lymphography for primary draining lymph node mapping works well in a majority of cases in all investigated sites and warrants further validation for different tumor entities.

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Hemolymphatic System

Worley¹

2022

Veterinary Surgical Oncology

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Pulmonary lymph node charting in normal dogs with blue dye and scintigraphic lymphatic mapping

Cited by 17 publications

References 23 publications

A Contemporary Retrospective Study of Survival in Dogs With Primary Lung Tumors: 40 Cases (2005–2017)

A Contemporary Retrospective Study of Survival in Dogs With Primary Lung Tumors: 40 Cases (2005–2017)

Computed tomographic‐lymphography as a complementary technique for lymph node staging in dogs with malignant tumors of various sites

Hemolymphatic System

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