Pulmonary <i>Mycobacterium abscessus</i> Infection with Reactive AA Amyloidosis: A Case Report and Brief Review of the Literature

Abstract

We herein report a case involving a 64-year-old Japanese woman with a pulmonary Mycobacterium abscessus infection complicated by reactive AA amyloidosis, which, to our knowledge, has not been reported to date. The patient underwent gastrointestinal endoscopy for diarrhea during the treatment of pulmonary M. abscessus infection and was diagnosed with AA amyloidosis according to the histopathological findings from the endoscopic specimen. She died four months later. The prognosis of AA amyloidosis associated with pulmonary M. abscessus infection may be very poor, and physicians should pay attention to this rare condition when difficult-to-treat diarrhea occurs in patients with pulmonary M. abscessus infection.

Mechanical Forces between Mycobacterial Antigen 85 Complex and Fibronectin

“…Recently, intrinsically multidrug resistant Mycobacteroides abscessus (formerly Mycobacterium abscessus) species have drawn great attention for the difficult-to-treat infections they cause among cystic fibrosis patients who appear particularly vulnerable to them [1,2]. Also, there are reports of deadly disseminated infections even among non-cystic fibrosis patients [3][4][5][6]. Therefore, innovative therapies are needed to supplement an inadequate supply of antimycobacterial agents in a context of increasing drug resistance.…”