Pulmonary Lipid-Laden Macrophages and Vaping

Maddock, Sean D.; Cirulis, Meghan M.; Callahan, Sean J.; Keenan, Lynn M; Pirozzi, C.S.; Raman, Sanjeev; Aberegg, Scott K.

doi:10.1056/nejmc1912038

Cited by 209 publications

(170 citation statements)

References 4 publications

Supporting

Mentioning

138

Contrasting

Unclassified

Order By: Relevance

“…Previous reports highlighted that patients with lung injury associated with e-cigarette use have used both THC- and nicotine-containing products ( 1 , 3 , 8 , 9 ). The additional information presented here regarding the range and diversity of brands used by patients, acquisition patterns, and frequency of use helps to formulate hypotheses about the possible etiology of this outbreak.…”

Section: Discussionmentioning

confidence: 99%

E-cigarette Product Use, or Vaping, Among Persons with Associated Lung Injury — Illinois and Wisconsin, April–September 2019

Ghinai¹,

Pray²,

Navon³

et al. 2019

MMWR Morb. Mortal. Wkly. Rep.

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

E-cigarette Product Use, or Vaping, Among Persons with Associated Lung Injury — Illinois and Wisconsin, April–September 2019

Ghinai¹,

Pray²,

Navon³

et al. 2019

MMWR Morb. Mortal. Wkly. Rep.

View full text Add to dashboard Cite

“…Greater than 2000 reported cases of vaping‐associated pulmonary injury and 39 deaths reported in the United States as of November 2019 have heightened public awareness and assumed major public health significance over recent months. E‐cigarette or vaping product use–associated lung injury (EVALI), the term designated by the Centers for Disease Control and Prevention (CDC) for this entity, is in many cases severe and may result in hospitalization, intubation, and mechanical ventilation and extracorporeal membrane oxygenation …”

Section: Cytomorphologic Features In Cases Of Confirmed and Probable mentioning

confidence: 99%

E‐cigarette or vaping product use–associated lung injury: What is the role of cytologic assessment?

Saqi

Mukhopadhyay

Butt

et al. 2020

Cancer Cytopathology

View full text Add to dashboard Cite

Greater than 2000 cases of vaping‐associated pulmonary injury and 39 deaths reported in the United States have heightened public awareness and assumed major public health significance over recent months. Currently, knowledge of the effects of various vaping agents on the respiratory tract is in its infancy. Additional understanding of the agents implicated in these lung injuries as well as a correlation between bronchoalveolar lavage and lung biopsy samples is required.

show abstract

“…Bronchoscopy and bronchoalveolar lavage have yielded variable results, with variable leucocytosis, no eosinophilia, and often 'foamy' or lipid-laden macrophages (positive O red or Sudan staining), which has led to the suggestion of 'lipoid pneumonia' changes (Viswam et al, 2018;Layden et al, 2019;Lewis et al, 2019;Maddock et al, 2019;Dicpinigaitis et al, 2020). However, the significance of this is controversial.…”

Section: Clinical Featuresmentioning

confidence: 99%

E-cigarette or vaping product use-associated lung injury

Ind

2020

Br J Hosp Med

View full text Add to dashboard Cite

E-cigarette or vaping product use-associated lung injury is a recently recognised, acute pulmonary syndrome which has been reported (particularly from June to October 2019) throughout the USA, but not in Europe (although one probable case, in the UK, has been reported; Medicines and Healthcare products Regulatory Agency, 2020 ). It presents acutely, most often in young men, as severe pulmonary consolidation, usually with respiratory failure. The mortality is around 2%. The cause(s) are unknown, but it is associated with vaping, particularly using unlicensed cannabis-containing products with tetrahydrocannabinol. Vitamin E acetate, often present in tetrahydrocannabinol-containing vape products as a solvent, has been implicated, as it has been identified in the bronchoalveolar lavage fluid of patients with e-cigarette or vaping product use-associated lung injury. This article reviews the recent literature, including clinical features, presentation and investigations, and possible mechanisms, in the context of vaping practices in the USA and the UK.

show abstract

Pulmonary Lipid-Laden Macrophages and Vaping

Cited by 209 publications

References 4 publications

E-cigarette Product Use, or Vaping, Among Persons with Associated Lung Injury — Illinois and Wisconsin, April–September 2019

E-cigarette Product Use, or Vaping, Among Persons with Associated Lung Injury — Illinois and Wisconsin, April–September 2019

E‐cigarette or vaping product use–associated lung injury: What is the role of cytologic assessment?

E-cigarette or vaping product use-associated lung injury

Contact Info

Product

Resources

About