Pulmonary lesions associated with Sjögren's syndrome: radiographic and CT findings

Matsuyama, Nobuki; Ashizawa, Kazuto; Okimoto, Tamio; Kadota, Jun‐ichi; Amano, Hideaki; Hayashi, Kuniaki

doi:10.1259/bjr/18937619

Cited by 72 publications

(58 citation statements)

References 14 publications

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“…This combination of signs is in accordance with LIP. In the study by MATSUYAMA et al [110] in patients with both pSS and secondary SS, it has been observed that centrilobular abnormalities and lymphoproliferative disorders pattern were characteristic in patients with pSS.…”

Section: Radiological Featuresmentioning

confidence: 92%

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Pivotal clinical dilemmas in collagen vascular diseases associated with interstitial lung involvement

Antoniou¹,

Margaritopoulos²,

Economidou³

et al. 2009

European Respiratory Journal

148

122

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The connective tissue disorders (CTDs), also called collagen vascular diseases (CVDs), represent a heterogeneous group of immunologically mediated inflammatory disorders with a large variety of affected organs. Individuals with a CTD (rheumatoid arthritis, systemic lupus erythematosus, systemic sclerosis, Sjögren's syndrome, polymyositis/dermatomyositis and mixed connective tissue disease) are susceptible to respiratory involvement. When the lungs are affected, an increasing mortality and morbidity in CVDs occurs. Interstitial lung disease (ILD) is established as a clinical corollary across the spectrum of CTDs, with an overall incidence estimated at 15%.Therefore, pivotal clinical dilemmas remain in the evaluation and management of ILD involvement in CVDs. Critical questions are the presence of fibrosis and whether the disease is clinically significant. Moreover, the clinician has to decide if treatment is warranted and which is the best therapeutic approach. The use of additional tests, such as pulmonary function tests, high-resolution computed tomography scan, bronchoalveolar lavage fluid and surgical lung biopsy, deserves better discussion. The present review focuses on establishing the diagnosis of ILD in CTD, and on evaluating disease activity and prognosis. This will provide the basis for therapeutic decisions that will be discussed, including an overview of recent advances.

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Section: Radiological Featuresmentioning

confidence: 92%

“…In patients with pSS, it has been found that bilateral lung infiltrates is the most common pattern seen on chest radiography [109]. It also has been found that in patients with both pSS and secondary SS, 22% had chest radiography abnormalities, with linear and reticular opacities being the most frequent finding [110].…”

Section: Radiological Featuresmentioning

confidence: 99%

Pivotal clinical dilemmas in collagen vascular diseases associated with interstitial lung involvement

Antoniou¹,

Margaritopoulos²,

Economidou³

et al. 2009

European Respiratory Journal

148

122

View full text Add to dashboard Cite

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“…When investigated systematically, prevalence increases to between 43% and 75% [37]. Computed tomography (CT) scan abnormalities are found in 34-50% of patients [38]. The annual incidence of respiratory manifestations is estimated at 10% (±3%) 1 year after diagnosis of Sjögren's syndrome and increases to 20% (±4%) by 5 years [6].…”

Section: Sjögren's Syndrome Patients With Pulmonary Involvementmentioning

confidence: 99%

“…Chest radiographs can show bilateral lung infiltrates with linear and reticular opacities (10-30%) [36,38,46]. Radiological abnormalities are not correlated with PFT and respiratory symptoms [91].…”

Section: Ild In Sjögren's Syndromementioning

confidence: 99%

Pulmonary manifestations of Sjögren's syndrome

et al. 2016

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In 9–20% of cases, Sjögren's syndrome is associated with various respiratory symptoms. The most typical manifestations are chronic interstitial lung disease (ILD) and tracheobronchial disease. The most common manifestation of ILD is nonspecific interstitial pneumonia in its fibrosing variant. Other types of ILD, such as organising pneumonia, usual interstitial pneumonia and lymphocytic interstitial pneumonitis, are rare. Their radiological presentation is less distinctive, and definitive diagnosis may require the use of transbronchial or surgical lung biopsy. Corticosteroid therapy is the mainstay of ILD treatment in Sjögren's syndrome, but the use of other immunosuppressive drugs needs to be determined. ILD is a significant cause of death in Sjögren's syndrome. Tracheobronchial disease is common in Sjögren's syndrome, characterised by diffuse lymphocytic infiltration of the airway. It is sometimes responsible for a crippling chronic cough. It can also present in the form of bronchial hyperresponsiveness, bronchiectasis, bronchiolitis or recurrent respiratory infections. The management of these manifestations may require treatment for dryness and/or inflammation of the airways. Airway disease has little effect on respiratory function and is rarely the cause of death in Sjögren's syndrome patients. Rare respiratory complications such as amyloidosis, lymphoma or pulmonary hypertension should not be disregarded in Sjögren's syndrome patients.

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“…2,4,21 Prevalence of lung involvement is SS varies widely (9%-75%) according to the diagnostic modalities and studied population. 36 The most frequent pulmonary manifestations of SS are ILD and airways disease. 2 The most common ILD pattern identified in patients with SS is NSIP, with other frequent patterns being OP, UIP, and LIP.…”

Section: Sjögren Syndromementioning

confidence: 99%