Pulmonary Large Cell Neuroendocrine Carcinoma Associated With Lambert-Eaton Syndrome

Abstract

Lambert-Eaton syndrome is a rare paraneoplastic disorder of the neuromuscular junction, characterized by impaired release of acetylcholine, which causes proximal muscle weakness, depressed tendon reflexes, and autonomic changes. Most cases of Lambert-Eaton syndrome present in small-cell lung carcinoma, and only a few cases have been reported in other lung subtypes. Herein, we report a case of 69 years old male patient with Lambert-Eaton syndrome as a rare association with a pulmonary large-cell neuroendocrine carcinoma, which presented 5 months before neoplasm diagnosis. A lobectomy was auspiciously performed. A review of the literature is also presented.

Lambert‐Eaton Myasthenic Syndrome in Lung Cancer

“…SCLC was predominant histological type [ 1 – 10 ]. LEMS with other types of lung tumors, including adenocarcinoma, large cell neuroendocrine carcinoma, and squamous cell carcinoma, is highly rare [ 1 – 10 ]. Lung adenocarcinoma accompanying LEMS is extremely rare.…”

“…Lung adenocarcinoma accompanying LEMS is extremely rare. There are only a few reported cases worldwide [ 10 ]. Symptoms of LEMS appeared prior to symptoms of lung cancer in the majority of patients [ 1 ].…”

“…LEMS may occur as a paraneoplastic disorder, most commonly in association with lung cancer. SCLC was predominant histological type [1][2][3][4][5][6][7][8][9][10]. LEMS with other types of lung tumors, including adenocarcinoma, large cell neuroendocrine carcinoma, and squamous cell carcinoma, is highly rare [1][2][3][4][5][6][7][8][9][10].…”

“…An increase in the CMAP amplitude (increment) of at least 100% are considered to have high specific for the diagnosis of LEMS. Its sensitivity ranged between 84 and 96% [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17].…”