Pulmonary Kaposi's sarcoma in the acquired immune deficiency syndrome

Meduri, Gianfranco U.; Stover, Diane E.; Lee, Marjorie; Myskowski, Patricia L.; Caravelli, James F.; Zaman, Mohd Saif

doi:10.1016/0002-9343(86)90175-0

Cited by 173 publications

(81 citation statements)

References 16 publications

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“…Although rare in solid organ transplant patients, pulmonary involvement of Kaposi's sarcoma has been described in up to 25% of living AIDS patients with cutaneous disease and in more than 50% of patients in autopsy studies [3,[11][12][13]. Various opportunistic infections have to be considered in the differential diagnosis of pulmonary infiltrates in immunocompromised patients.…”

Section: Discussionmentioning

confidence: 99%

Detection of herpesvirus-like DNA in the bronchoalveolar lavage fluid of patients with pulmonary Kaposi's sarcoma

Cathomas

Tamm²,

Ce³

et al. 1996

Eur Respir J

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Pulmonary involvement is a clinically important form of visceral Kaposi's sarcoma in immunocompromised patients. Recently, herpesvirus-like deoxyribonucleic acid (DNA) sequences, defining a new herpesvirus termed "human herpesvirus 8" (HHV8) or "Kaposi's sarcoma-associated herpesvirus" (KSHV), were detected in Kaposi's sarcoma of acquired immune deficiency syndrome (AIDS) and non-AIDS patients. We describe the successful detection of HHV8 DNA in the bronchoalveolar lavage (BAL) fluid of patients with pulmonary Kaposi's sarcoma.Three immunocompromised patients, two HIV seropositive and one after kidney transplantation, suffered from respiratory symptoms and showed pulmonary infiltrates on chest radiography after development of biopsy proven Kaposi's sarcoma of the skin. Bronchoscopy revealed the typical Kaposi like livid endobronchial lesions. BAL fluid was analysed for the presence of HHV8 DNA using a nested polymerase chain reaction (PCR) assay.HHV8 DNA was detected in the BAL fluid of all three patients. In addition, HHV8 DNA could be detected in the skin biopsy tissue, lymph node, and peripheral blood mononuclear cells of these patients.Our data show that human herpesvirus 8 deoxyribonucleic acid can be detected in the bronchoalveolar lavage fluid of patients with pulmonary Kaposi's sarcoma. If further studies reveal a high specificity for human herpesvirus 8 deoxyribonucleic acid detection, this test will improve the tools for the diagnosis of pulmonary Kaposi's sarcoma without further need of biopsies. Eur Respir J., 1996Respir J., , 9, 1743Respir J., -1746

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Section: Discussionmentioning

confidence: 99%

Detection of herpesvirus-like DNA in the bronchoalveolar lavage fluid of patients with pulmonary Kaposi's sarcoma

Cathomas

Tamm²,

Ce³

et al. 1996

Eur Respir J

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“…In clinical studies pulmonary Kaposi's sarcoma has been reported in 3-13% of patients with AIDS23 and in up to 32% of patients with AIDS who had cutaneous Kaposi's sarcoma.245 In contrast, bronchopulmonary Kaposi's sarcoma was found at necropsy in 47% of patients with AIDS who had cutaneous Kaposi's sarcoma. 6 The diagnosis of pulmonary Kaposi's sarcoma may be difficult to make during life. Presenting symptoms and chest radiographic appearances are non-specific and non-invasive investigations, including exercise testing and arterial blood gas estimation, do not distinguish bronchopulmonary Kaposi In seven ofthe 20 patients the tracheobronchial Kaposi's sarcoma was localised and in 13 patients the lesions were widespread.…”

Section: Introductionmentioning

confidence: 99%

Bronchopulmonary Kaposi's sarcoma in patients with AIDS.

Miller¹,

Tomlinson²,

Cottrill³

et al. 1992

Thorax

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“…Disseminated Kaposi's sarcoma (KS) is a common problem in patients with the acquired immunodeficiency syndrome. Intrathoracic involvement occurs clinically in as many as a fifth of patients with KS [4,5], and has been reported in 11 of 23 consecutive patients in an autopsy series [6]. Pulmonary KS, usually, follows the appearance of characteristic lesion of the skin [7].…”

Section: Introductionmentioning

confidence: 99%

Bilateral Chylothorax. An Unusual Presentation in the Course of Immune Reconstitution Inflammatory Syndrome, HIV Infection and Kaposi’s Sarcoma: A Case Report

Boultadakis

2014

J Med Cases

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Immune reconstitution inflammatory syndrome (IRIS) is a term used to describe the paradoxical worsening of a pre-existing infection or the presentation of a previously undiagnosed condition in HIV-infected patients soon after commencement of antiretroviral therapy (ART). We report a case of a patient with HIV infection and Kaposi sarcoma, who developed bilateral chylothorax as a manifestation of IRIS, after the initiation of highly active antiretroviral therapy. Bilateral chylothorax is extremely rare and has been associated with significant morbidity and mortality. We present here the successful management with bilateral video-assisted thoracic surgery.

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Pulmonary Kaposi's sarcoma in the acquired immune deficiency syndrome

Cited by 173 publications

References 16 publications

Detection of herpesvirus-like DNA in the bronchoalveolar lavage fluid of patients with pulmonary Kaposi's sarcoma

Detection of herpesvirus-like DNA in the bronchoalveolar lavage fluid of patients with pulmonary Kaposi's sarcoma

Bronchopulmonary Kaposi's sarcoma in patients with AIDS.

Bilateral Chylothorax. An Unusual Presentation in the Course of Immune Reconstitution Inflammatory Syndrome, HIV Infection and Kaposi’s Sarcoma: A Case Report

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