Pulmonary involvement in patients with early rheumatoid arthritis

Metafratzi, Zafiria M.; Georgiadis, A.; Ioannidou, C V; Alamanos, Yannis; Vassiliou, M; Zikou, Anastasia; Raptis, George; Drosos, Alexandros A.; Efremidis, Stauros C.

doi:10.1080/03009740701393957

Cited by 76 publications

(62 citation statements)

References 40 publications

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“…All the other abnormalities were found in the control group at the same frequency as in the patients. DAS-28, PFT, and the Larsen score showed no significant correlations with either each HRCT sign score separately or the total score 7 .…”

Section: To the Editormentioning

confidence: 69%

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Pulmonary Abnormalities in Patients with Early and Longstanding Rheumatoid Arthritis

Georgiadis¹,

Metafratzi²,

Drosos³

2009

J Rheumatol

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Section: To the Editormentioning

confidence: 69%

“…The third point is that no control group was included in their study (healthy nonsmokers). Our group investigated the pulmonary abnormalities in patients with early RA using high resolution computed tomography (HRCT) 7 . For this reason 43 patients with early RA were included.…”

Section: To the Editormentioning

confidence: 99%

Pulmonary Abnormalities in Patients with Early and Longstanding Rheumatoid Arthritis

Georgiadis¹,

Metafratzi²,

Drosos³

2009

J Rheumatol

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“…Sensitive diagnostic methods such as high resolution computed tomography (HRCT) have revealed structural changes in the lungs in early disease. Metafrazi found lung abnormalities, including ground glass opacities, among 69% of 43 never-smoking patients with early RA, but not in control subjects [133]. Demourelle has reported structural lung changes among ACPA positive non-smoking subjects [134], indicating that other irritants than cigarette smoke may contribute to the initial inflammatory process preceding clinically manifest RA.…”

Section: The Lungsmentioning

confidence: 99%

Circulating and Mucosal Antibodies to Citrullinated Antigens in Rheumatoid Arthritis

Svärd¹

2014

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Rheumatoid arthritis (RA) is an autoimmune disease characterized by joint inflammation and subsequent destruction of cartilage and bone. The etiology is largely unknown, although genetic as well as environmental factors are involved. The manifestations and consequences of RA differ between individuals. This makes it important to find early markers for the disease course, in order to enable the most suitable treatment. IgG antibodies to cyclic citrullinated peptides (CCP) have high specificity for RA, but only around 60% of RA patients test positive for IgG anti-CCP. The aim of this thesis was to evaluate the usefulness of serum IgA anti-CCP as a diagnostic maker compared to IgG anti-CCP, and to assess IgA versus IgG anti-CCP status in relation to smoking habits and genetic background. Another aim was to evaluate signs of mucosal immunization by analyzing salivary IgA anti-CCP. IgA anti-CCP was present in a subgroup of RA patients with high levels of IgG anti-CCP and a slightly more severe disease course. Similar results were found regarding IgA class antibodies to modified citrullinated vimentin (MCV). IgG anti-MCV had slightly higher sensitivity for RA than IgG anti-CCP, thus identifying a group of IgG anti-CCP negative patients with an unfavourable disease course. However, the lower diagnostic specificity of IgG anti-MCV limits its usefulness. Among 63 patients with established RA, salivary IgA anti-CCP was found in 22% and was associated with a more favourable outcome regarding erosive joint disease at follow-up. IgA anti-CCP in serum was strongly associated with smoking, and the earlier known interaction between smoking and shared epitope (SE) was here shown to be valid only for subjects positive for IgA anti-CCP in combination with IgG anti-CCP. In conclusion, IgG anti-CCP is still the most useful serologic marker of RA, but IgA anti-CCP should be further investigated as a prognostic marker. The association between smoking and IgA anti-CCP strongly indicates a pathogenic role for smoking and IgA anti-CCP, supporting the possibility that RA may originate from chronic airway irritation. The less erosive disease in patients positive for salivary IgA anti-CCP indicates a protective role of secretory IgA anti-CCP

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“…This demonstrated that the synovium in ACPA-positive patients is initially normal, even in patients who later develop clinical arthritis. In addition, existing evidence suggests that a proportion of patients with positive RA serology may already have HRCT parenchymal lung changes at time of RA diagnosis (Gabbay et al, 1997, Metafratzi et al, 2007, Reynsdottir et al, 2011. In fact, a retrospective study by Gizinski et al (2009) showed that positive RA serology can be found in smokers with ILD without symptoms and signs of RA, but who may later develop RA.…”

Section: Environmental Triggers Of Pulmonary Inflammationmentioning

confidence: 99%

Rheumatoid Arthritis Interstitial Lung Disease

Vinik¹,

Marras²,

Shapera³

et al. 2011

Challenges in Rheumatology

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Pulmonary involvement in patients with early rheumatoid arthritis

Abstract: Lung abnormalities are frequently observed in patients with early RA on HRCT, even when CXR and PFTs are normal. Limited areas of GGOs were the abnormalities depicted exclusively in patients.

Cited by 76 publications

References 40 publications

Pulmonary Abnormalities in Patients with Early and Longstanding Rheumatoid Arthritis

Pulmonary Abnormalities in Patients with Early and Longstanding Rheumatoid Arthritis

Circulating and Mucosal Antibodies to Citrullinated Antigens in Rheumatoid Arthritis

Rheumatoid Arthritis Interstitial Lung Disease

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