Pulmonary Involvement in Henoch-Schnlein Purpura

Nadrous, Hassan F.; Yu, Aimee C.; Specks, Ulrich; Ryu, Jay H.

doi:10.1016/s0025-6196(11)62598-6

Cited by 40 publications

(13 citation statements)

References 43 publications

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“…[3][4][5][6][7][8] Pulmonary hemorrhage is also a rare complication of HSP. 9,10 To our knowledge, this is the first to report the involvement of both cardiac of pulmonary systems in HSP.…”

Section: Discussionmentioning

confidence: 84%

A case of Henoch-Schönlein purpura with cardiopulmonary involvement

Tan

2015

Rheumatol Rep

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Henoch-Shönlein purpura (HSP) commonly affects the kidney, causing hematuria and Immunoglobulin A type nephropathy. Extrarenal involvements are rare but can be life threatening if missed. Cardiac involvement has been described only in a handful of case reports. Although HSP is predominantly a pediatric disease, it should not be overlooked in older patients presenting with typical triad of symptoms. We report a rare case of HSP with both cardiac of pulmonary systems involvement and his clinical progress

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“…[3][4][5][6][7][8] Pulmonary hemorrhage is also a rare complication of HSP. 9,10 To our knowledge, this is the first to report the involvement of both cardiac of pulmonary systems in HSP.…”

Section: Discussionmentioning

confidence: 84%

A case of Henoch-Schönlein purpura with cardiopulmonary involvement

Tan

2015

Rheumatol Rep

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“…Diffuse alveolar hemorrhage is exceedingly rare in Henoch-Schönlein purpura but can be seen, as in our patient. 9,10 In this setting, the findings of IgA deposits in skin and renal biopsy specimens, together with the absence of other clinical, serologic, or histologic features of other more-common potential causes, secured the diagnosis in this patient.…”

Section: Different Presentation In Adults Vs Childrenmentioning

confidence: 74%

A 72-year-old man with a purpuric rash

Goel

Langford

2009

CCJM

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A 72-year-old man with a purpuric rash A 72-year-old man whose medical history includes diabetes mellitus, hypertension, coronary artery disease, aortic valve replacement, atrial fibrillation, and chronic obstructive pulmonary disease was in his usual state of health until 2 weeks ago, when he developed a purpuric rash on his legs. His physician started him on prednisone 40 mg daily for the rash; however, 1 week later he presented to a hospital emergency room when his family found him confused and diaphoretic. In the emergency room, he was found to be hypoglycemic, with a serum glucose level of 40 mg/dL, which was promptly treated. His mental status improved partially. In the hospital, the rash worsened and progressed upwards to his trunk and upper extremities. He was transferred to our institution for further workup and management. A review of systems reveals occasional epistaxis in the summer, recent fatigue, cough, and shortness of breath on exertion. His medications at the time of transfer include warfarin (Coumadin), amlodipine (Norvasc), insulin, ipratropium and albuterol (Combivent) inhalers, and prednisone 40 mg daily. He has not undergone surgery recently. Physical examination ■ He is alert and oriented to person but not to time and place. Vital signs. Oral temperature 101.1°F (38.4°C), pulse rate 108, blood pressure 108/79 mm/Hg, respiratory rate 22, oxygen saturation 93% by pulse oximetry on room air, weight 94 kg (207 lb). Head, eyes, ears, nose, and throat. No pallor or icterus, pupils are equally reactive, nasal mucosa not inflamed or ulcerated, mucous membranes moist, no sinus tenderness. Neck. No jugular venous distention and no cervical lymphadenopathy. Cardiovascular. Tachycardia, irregularly irregular rhythm, prosthetic valve sounds, no murmurs, rubs, or gallops. Respiratory. Bibasal crackles (right side more than the left). No wheezing. Abdomen. Soft, nontender, nondistended, no palpable organomegaly, bowel sounds normal. Extremities. No edema, good peripheral pulses. Skin. Diffuse, nonblanching, petechialpurpuric rash (FIGURE 1) with scaling on both legs and extending up to the abdomen, flanks, chest, and both arms.

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“…4 It is rare in other primary small vessel vasculitides such as Churg-Strauss syndrome (CSS) [5][6][7] or Henoch-Schönlein purpura. 8 Pulmonary capillaritis is occasionally a prominent feature in patients with secondary vasculitides such as those occurring in the context of collagen vascular disorders including systemic lupus erythematosus (SLE), 9 antiphospholipid syndrome (APS), 10,11 rheumatoid arthritis (RA), 12 and polymyositis. 13 Drug-induced vasculitis can also manifest itself in the form of pulmonary capillaritis.…”

Section: Definitionsmentioning

confidence: 99%

“…DAH has been described as a complication of both immunoglobulin A (IgA) nephropathy and Henoch-Schönlein purpura. 8,66 Only 26 cases of DAH in Henoch-Schönlein purpura have been reported to date. 8 Capillaritis has been documented histopathologically in a minority of them.…”

Section: Drug-induced Vasculitismentioning

confidence: 99%

“…8,66 Only 26 cases of DAH in Henoch-Schönlein purpura have been reported to date. 8 Capillaritis has been documented histopathologically in a minority of them. IgA deposits along the pulmonary capillary walls, analogous to those found in vessels of the skin and glomeruli of affected kidneys, are pathognomonic features of Henoch-Schönlein purpura detectable by direct immunofluorescence.…”

Section: Drug-induced Vasculitismentioning

confidence: 99%

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Pulmonary Capillaritis

Lee

Specks

2004

Seminars in Respiratory and Critical Care Medicine

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Pulmonary capillaritis is defined as a histopathologic pattern of alveolar wall inflammation that leads to the disruption of the integrity of alveolar-capillary basement membranes and flooding of the alveoli with blood. The clinical presentation is that of diffuse alveolar hemorrhage (DAH). Pulmonary capillaritis is usually the consequence of an underlying immune-mediated process that is systemic in nature. Rarely, pulmonary capillaritis occurs in isolation. This article outlines a systematic approach to the management of patients presenting with DAH, and provides an overview of specific causes of pulmonary capillaritis.

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Pulmonary Involvement in Henoch-Schnlein Purpura

Cited by 40 publications

References 43 publications

A case of Henoch-Schönlein purpura with cardiopulmonary involvement

A case of Henoch-Schönlein purpura with cardiopulmonary involvement

A 72-year-old man with a purpuric rash

Pulmonary Capillaritis

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