Pulmonary intra-arteriolar thrombi associated with cancer

Berkheiser, S. W.

doi:10.1002/1097-0142(195801/02)11:1<99::aid-cncr2820110120>3.0.co;2-j

Cited by 6 publications

(5 citation statements)

References 5 publications

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“…Activation of the coagulation and fibrinolytic pathways is a common manifestation of colon cancer (1)(2)(3)(4)(5)(6). This activation may be evident by abnormalities in tests of both the thrombin-forming (7)(8)(9) and fibrinolytic (9-11) pathways, and by thromboembolism (12)(13)(14)(15)(16). It has been postulated that coagulation activation may promote tumor growth because anticoagulant treatment of tumor bearing experimental animals may retard tumor progression in some (but not all) model systems (17).…”

Section: Introductionmentioning

confidence: 99%

Indirect Activation of Blood Coagulation in Colon Cancer

et al. 1989

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SummarySystemic activation of the coagulation mechanism is known to exist in patients with colon cancer. The mechanism of such activation was investigated using immunohistochemical techniques applied to fresh frozen sections of resected primary colon cancer specimens. Tumor cells stained for tissue factor, factor V, and urokinase-type plasminogen activator. Perivascular and intercellular areas stained for fibrinogen and the “a” subunit of factor XIII. Staining was minimal or absent for protein C, protein S, plasminogen activator inhibitors 1-3, factor VII, factor X, and fibrin (the antigenic site on the amino-terminal portion of Bβ chain that is exposed following thrombin cleavage of fibrinopeptide B was not detected). The lack of an intact thrombin- generating pathway in situ associated with viable colon cancer cells is consistent with the findings of others that coagulation activation in colon cancer may be triggered by a soluble tumor product that exerts its effect at sites distant from the tumor. These results may explain the absence of clinical responsiveness of colon cancer to antithrombotic drug therapy and may clarify therapeutic strategies for this common tumor.

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Section: Introductionmentioning

confidence: 99%

Indirect Activation of Blood Coagulation in Colon Cancer

et al. 1989

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“…67 Beyond the punishments imposed, which can include blended or determinate sentencing, 68 juvenile adjudications can also lead to a host of negative collateral consequences that can seriously limit the life chances of youth, including sex offender registration, 69 preclusion from public housing, limited employment and educational opportunities, or ineligibility to serve in the military. 70 Juvenile adjudications might also be used to enhance sentences 71 or automatically transfer juveniles to adult court for future offenses 72 and might count as strikes under "three strikes" laws. 73 Immigrant youth transferred to criminal court could face deportation.…”

Section: The Increasingly High Stakes Of Court Involvementmentioning

confidence: 99%

“…73 Immigrant youth transferred to criminal court could face deportation. 74 Yet, despite these punitive long-term consequences, many children endure the court process without any meaningful representation, understanding, or participation.…”

Section: The Increasingly High Stakes Of Court Involvementmentioning

confidence: 99%

“…83 A disproportionate number of youth in the delinquency courts are diagnosed with mental illnesses, like substance abuse, psychosis, autism, conduct disorder, attention-deficit disorder, mood and anxiety disorders, and posttraumatic stress disorder. 84 While estimates vary, some studies have found that up to 70% of youth in the system have developmental disorders or neuropsychiatric impairments. 85 Between 17-53% of delinquents have learning disabilities as compared with the 2-10% rate of learning disabilities among youth generally.…”

Section: The Children Affected By Ineffective Indigent Defense Systemsmentioning

confidence: 99%

“…119 For example, research suggests that children with guns often do not intend to use them to injure someone, but rather carry them to intimidate others. 120 In addition, a youth's offense may appear vengeful, when it is actually motivated by the youth's desire to please others, sense of morality, and intolerance of things that seem unfair. 121 And reconciling conflicting identities (such as between family and peer expectations) may lead to unpredictable behavior, particularly when a youth is under stress.…”

Section: Integrating Knowledge Of Youth Development Into Advocacymentioning

confidence: 99%

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Ensuring Authentic Youth Participation in Delinquency Cases: Creating a Paradigm for Specialized Juvenile Defense Practice

Puritz

Majd²

2007

Family Court Review

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In delinquency courts, juvenile defense attorneys are essential for guaranteeing children's due process rights and encouraging their meaningful participation in the proceedings. Yet, indigent defense delivery systems are largely failing youth accused of committing crimes. This article highlights the importance of developing systems that support the highly specialized practice area of juvenile defense. To protect their clients’ rights and meet their ethical obligations, juvenile defense attorneys must zealously advocate for their clients’ expressed interests and must strategically address the biases and misunderstandings prevalent in delinquency courts. Specifically, defense attorneys must vigorously challenge systemic race, class, and gender injustices; incorporate expert knowledge of youth development into their advocacy; and protect clients’ mental health and educational interests. Such holistic representation promotes rehabilitation and reduces recidivism. Because of numerous obstacles that currently impede defense attorneys from engaging in such exemplary practice, systemic reforms are necessary to support high‐quality defense representation and, ultimately, ensure that youths’ rights are protected.

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Vermehrung der F�lle von Thrombose und Lungenembolie und ihre Ursachen

Bartók

1960

Virchows Arch. path Anat.

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Pulmonary intra-arteriolar thrombi associated with cancer

Cited by 6 publications

References 5 publications

Indirect Activation of Blood Coagulation in Colon Cancer

Indirect Activation of Blood Coagulation in Colon Cancer

Ensuring Authentic Youth Participation in Delinquency Cases: Creating a Paradigm for Specialized Juvenile Defense Practice

Vermehrung der F�lle von Thrombose und Lungenembolie und ihre Ursachen

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