Pulmonary infection due to Acrophialophora fusispora in a patient with underlying mixed connective tissue disease and chronic pulmonary aspergillosis: A case report and review of literature

Samaddar, Arghadip; Sharma, Anuradha; Shrimali, Twishi

doi:10.1016/j.mycmed.2020.100932

Cited by 12 publications

(14 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Compared with HCs, albumin decreased and ALT and GGT increased in both H1N1 patients and COVID-19 patients, suggesting of the patients experienced liver injury. Interestingly, AST increased in only H1N1 patients, and was even higher than that in COVID- 19 patients, suggesting that more serious liver injury might occur in H1N1 patients. ALP decreased in only COVID-19 patients compared to HCs, suggesting that kidney injury and anaemia may occur in these patients ( Fig.…”

Section: In Ammation In H1n1 and Covid-19 Patientsmentioning

confidence: 91%

“…Although the infectivity and mortality of SARS-CoV-2 are much higher than those of in uenza viruses and their treatment methods are quite different, [1][2][3] patients with coronavirus disease 2019 (COVID- 19) caused by SARS-CoV-2 and in uenza viruses such as in uenza A (H1N1) have many very similar symptoms, such as fever, cough, vomiting, and diarrhoea. [4][5][6] This will pose greater challenges to the prevention and treatment of COVID-19 when u season arrives.…”

Section: Introductionmentioning

confidence: 99%

“…Moreover, fungal co-infection strongly affected the prognosis of H1N1 patients. [18][19][20] H1N1 virus infection causes an impaired host immune response against fungi, which in turn leads to fungal proliferation. 21 However, it is still unclear whether alterations in the gut mycobiota occur and whether they are associated with health and diseases in patients with COVID-19 and H1N1.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Gut mycobiota alterations in patients with COVID-19 and H1N1 and associations with immune and gastrointestinal symptoms

Jiang

et al. 2020

Preprint

View full text Add to dashboard Cite

The relationship between gut microbes and COVID-19 or H1N1 flu is not fully understood. Here, we compared gut mycobiota of 67 COVID-19 patients, 35 H1N1 patients and 48 healthy controls (HCs) using internal transcribed spacer (ITS) 3-ITS4 sequencing. Fungal richness decreased in COVID-19 and H1N1 patients compared to HCs, but fungal diversity decreased in only H1N1 patients. Fungal mycobiota dysbiosis in both COVID-19 and H1N1 patients was mainly characterized by depletions of fungi such as Aspergillus, Penicillium, but several fungi, such as Candida parapsilosis, and Malassezia yamatoensis, were enriched in H1N1 patients. The altered fungal taxa were strongly associated with clinical features such as the incidence of diarrhoea, albumin. Gut mycobiota between COVID-19 patients with mild and severity symptoms are not different, as well as between COVID-19 patients in and out hospital. Therefore, gut mycobiota dysbiosis occur in covid-19 or H1N1 patients and do not improve until discharge.

show abstract

Section: In Ammation In H1n1 and Covid-19 Patientsmentioning

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Gut mycobiota alterations in patients with COVID-19 and H1N1 and associations with immune and gastrointestinal symptoms

Jiang

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

“…Acrophialophora infections are rare; there are only 13 documented infections to date, with the first diagnosis occurring in 1981 (Table 1) [1][2][3][4][5][6][7][8][9][10][11][12][13][14]. Out of these, 10 were caused by A. fusispora, two were caused by A. levis, and one was caused by an unspecified Acrophialophora species.…”

Section: Review Raritymentioning

confidence: 99%

“…Out of these, 10 were caused by A. fusispora , two were caused by A. levis , and one was caused by an unspecified Acrophialophora species. Additionally, there have been six documented cases of Acrophialophora colonization without signs of infection, largely in patients diagnosed with cystic fibrosis (CF) [ 4 , 5 , 8 ]. Some of these infections were confirmed as Acrophialophora by sequencing, but others were only identified morphologically, which could potentially mean that there were false positives [ 7 ].…”

Section: Reviewmentioning

confidence: 99%

Acrophialophora: A Comprehensive Review of Clinical Guidelines and Diagnosis

Bhattaru¹,

Blanchard²,

Kunamneni³

et al. 2023

Cureus

View full text Add to dashboard Cite

Acrophialophora is a saprotrophic genus of fungi found in both temperate and tropical regions. The genus is comprised of 16 species, with the subspecies A. fusispora and A. levis necessitating the most clinical concern. Acrophialophora is an opportunistic pathogen with a broad range of clinical manifestations; the fungus has been implicated in cases of fungal keratitis, lung infection, and brain abscess. Acrophialophora infection is particularly of concern for immunocompromised patients, who often present with a more severe disease course involving disseminated infection and may not exhibit typical symptoms. Early diagnosis and therapeutic intervention are critical to the successful clinical management of Acrophialophora infection. Guidelines for antifungal treatment have yet to be established, partially due to the lack of documented cases. Aggressive use of antifungal agents and long-term treatment is required, especially in immunocompromised patients and patients with systemic involvement, due to the potential for morbidity and mortality. In addition to outlining the rarity and epidemiology of the disease, this review provides an overview of the diagnosis and clinical management of Acrophialophora infection to facilitate an early diagnosis and appropriate interventions.

show abstract

Milestones in Medical Mycology in India

Gugnani

2021

Progress in Mycology

View full text Add to dashboard Cite

Pulmonary infection due to Acrophialophora fusispora in a patient with underlying mixed connective tissue disease and chronic pulmonary aspergillosis: A case report and review of literature

Cited by 12 publications

References 19 publications

Gut mycobiota alterations in patients with COVID-19 and H1N1 and associations with immune and gastrointestinal symptoms

Gut mycobiota alterations in patients with COVID-19 and H1N1 and associations with immune and gastrointestinal symptoms

Acrophialophora: A Comprehensive Review of Clinical Guidelines and Diagnosis

Milestones in Medical Mycology in India

Contact Info

Product

Resources

About