Pulmonary Infection and its Management in Cystic Fibrosis Patients in the Czech Republic

Vávrová, V.; Jedlickova, Z; Lochmann, O; Zemková, D; Krásnicanová, H; Maçek, Milan; MacekJr, Milan; Zapletal, A; Biolek, Jiří; Holčíková, Alena; Honomichlová, Helena; Kolek, Antonín; Musil, J; Sekyrová, I; Šuláková, Miroslava; Ťoukálková, Lenka; Vaníček, H.

doi:10.1007/978-3-0348-7359-8_21

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“…Another group of pathogens, the Burkholderia cepacia complex, was found only in relatively low and stable abundance among CF patients (~3-4%) [8]. The prevalence of the complex was 4.4% of Czech CF patients in year 1996 [2], but during outbreaks in 1997-2003 the number increased to 30% [9,10]. The B. cepacia complex encompasses the most threatening CF pathogens, owing to dramatic increase in symptoms and decline in pulmonary function and causes a potentially fatal necrotizing pneumonia with bacteraemia (so called Cepacia Syndrome) [11].…”

Section: Introductionmentioning

confidence: 99%

“…Breath analysis represents a very desirable approach for non-invasive diagnosis and monitoring of bacterial infections in patients with cystic fibrosis (CF). CF is one of the most common inherited autosomal recessive diseases; its occurrence is estimated worldwide 1 in 2000-3000 amongst Caucasian newborns [1] and in the Czech Republic it is 1 in 2500 live births [2]. In CF, defects or complete dysfunction of transmembrane conductance channel are caused by genetic mutations resulting in failure of the self-cleaning function of mucous membranes in airways and other organs.…”

Section: Introductionmentioning

confidence: 99%

“…Pseudomonas aeruginosa is a very important CF Differentiation of pulmonary bacterial pathogens in cystic fibrosis by volatile metabolites emitted by their in vitro cultures: Pseudomonas aeruginosa, Staphylococcus aureus, Stenotrophomonas maltophilia and the Burkholderia cepacia complex pathogen, in Europe, 20% of CF patients are infected by P. aeruginosa before 2 years of age and the likelihood of infection increases with age reaching 80% for adult patients (>18 years old) [6,7]. Note that it affects about 50% of all CF patients in the Czech Republic [2]. Another group of pathogens, the Burkholderia cepacia complex, was found only in relatively low and stable abundance among CF patients (~3-4%) [8].…”

Section: Introductionmentioning

confidence: 99%

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Differentiation of pulmonary bacterial pathogens in cystic fibrosis by volatile metabolites emitted by their in vitro cultures: Pseudomonas aeruginosa , Staphylococcus aureus , Stenotrophomonas maltophilia and the Burkholderia cepacia complex

et al. 2016

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As a contribution to the continuing search for breath biomarkers of lung and airways infection in patients with cystic fibrosis, CF, we have analysed the volatile metabolites released in vitro by Pseudomonas aeruginosa and other bacteria involved in respiratory infections in these patients, i.e. those belonging to the Burkholderia cepacia complex, Staphylococcus aureus or Stenotrophomonas maltophilia. These opportunistic pathogens are generally harmless to healthy people but they may cause serious infections in patients with severe underlying disease or impaired immunity such as CF patients. Volatile organic compounds emitted from the cultures of strains belonging to the above-mentioned four taxa were analysed by selected ion flow tube mass spectrometry. In order to minimize the effect of differences in media composition all strains were cultured in three different liquid media. Multivariate statistical analysis reveals that the four taxa can be well discriminated by the differences in the headspace VOC concentration profiles. The compounds that should be targeted in breath as potential biomarkers of airway infection were identified for each of these taxa of CF pathogens.

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