Pulmonary Impairment After Tuberculosis

Pasipanodya, Jotam G.; Miller, Thaddeus L.; Vecino, Mauricio; Munguia, Guadalupe; Garmon, Robert G.; Bae, Sejong; Drewyer, Gerry; Weis, Stephen E.

doi:10.1378/chest.06-2949

Cited by 192 publications

(216 citation statements)

References 17 publications

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“…These findings were similar to Pasipanodya et al and Banurekha et al studies. 2,6 However, Mean scores for symptom, activity, impact and overall scores in the present study were higher than the Banurekha et al study. 6 Limitations of the study: Like any other retrospective study, accuracy of data collected is questionable.…”

Section: Discussioncontrasting

confidence: 73%

“…1 Despite microbiological cure, pulmonary tuberculosis is associated with extensive residual lung damage, that can be a predictor for disability permanently after the tissue destruction, leading to increased susceptibility to all opportunistic infections, finally causing impairment in their quality of life. 2 Pulmonary impairment adds to the unmeasured burden of TB in microbiologically cured patients than can lead to chronic impairment and excess mortality varying from mild to severe. 2 There are currently no recommendations for impairment evaluation or other follow up for patients completing therapy for tuberculosis (ATS 2003).…”

Section: Introductionmentioning

confidence: 99%

“…2 Pulmonary impairment adds to the unmeasured burden of TB in microbiologically cured patients than can lead to chronic impairment and excess mortality varying from mild to severe. 2 There are currently no recommendations for impairment evaluation or other follow up for patients completing therapy for tuberculosis (ATS 2003). 3 Both the ideal method to identify and evaluate persons with pulmonary impairment after tuberculosis and its impact on population health are also unknown.…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of respiratory impairment and health related quality of life in pulmonary tuberculosis sequelae patients

Meyyappan

Chockalingam

2018

Int J Adv Med

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Background: Pulmonary tuberculosis is a common disease that can result in residual anatomical and functional changes despite microbiological cure. But the ideal method to identify and evaluate persons with pulmonary impairment after tuberculosis and its impact on population health are unknown. Hence the study was conducted with the aim of the present study was to Evaluate the respiratory and cardiac impairment and to assess the health related quality of life in pulmonary tuberculosis sequelae patients.Methods: This observational study was conducted on 200 patients randomly at the Institute of thoracic medicine at Chetpet and Rajiv Gandhi government general hospital, Chennai during a period of 6 months from April 2013 to October 2013. All patients were investigated for sputum for acid fast Bacillus, chest skiagram, spirometry, electrocardiogram, echo, six minute walk test and St. George respiratory questionnaire.Results: In this study, spirometry abnormalities were present in 81% of patients. No significant correlation observed between smoking index and pulmonary function abnormality (0.145). However, moderate correlation was seen between radiology and pulmonary function abnormality (0.307). 98% of the patients showed diminished exercise capacity. The prevalence of corpulmonale was increased with the degree of radiological impairment progress from grade 1 to 3 with a moderate correlation (0.385). No significant correlation (0.198) was noticed between the parameters smoking index and exercise capacity. The overall SGRQ scores mean (SD) were 54±11.5, 41.7±24.7, 28.9±19.6 and 37.0±19.1 for the symptom, activity, impact and overall scales respectively. No significant relationship was noticed between smoking index and SGRQ total score (p=0.512).Conclusions: The present study confirms that there is significant functional limitation in pulmonary sequelae, addressing the need of pulmonary rehabilitation for better quality of life. Smoking cessation therapy all can improve their quality of life after pulmonary impairment. Cardiac evaluation must be done in all post tuberculosis patients to rule out corpulmonale.

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Section: Discussioncontrasting

confidence: 73%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Evaluation of respiratory impairment and health related quality of life in pulmonary tuberculosis sequelae patients

Meyyappan

Chockalingam

2018

Int J Adv Med

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“…[6,13] In females, biomass gas inhalation and smoke from cooking fires or other sources are found to contribute risk in TB. [13] The pulmonary impairment was present in 45.6% of patients including airway obstruction in 32.3% of patients, restrictive pattern in 9.2% of patients, and 4.1% of patients had combined pattern. [14] Abnormal PFT findings were 5.4 times more likely in survivors of pulmonary TB patients.…”

Section: Discussionmentioning

confidence: 99%

“…Treated pulmonary TB patients are free from mycobacterium infection but have variable presentation of lung function findings affecting the quality of patient's life. [9,[12][13][14][15][16] India strategic plans to work on chemoprophylaxis and also preventive measures in halting spread of TB. There is the need to know the extent of the impairment of lung function in pulmonary TB-treated patients in India, so that proper planning to ensure the functional restoration in lungs in treated patients can be done.…”

Section: Tuberculosis (Tb) Is a Chronic Disease Caused Bymentioning

confidence: 99%

A six-month follow-up study to evaluate changes of pulmonary function test in Category I pulmonary tuberculosis treatment completed patient

Patil¹,

Patil²

2017

Natl J Physiol Pharm Pharmacol

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Background: Tuberculosis (TB) is being a preventable and curable disease that it accounts the world-wide problem. India is one of the TB burden countries. Clinical manifestation of pulmonary TB leads pulmonary dysfunction with functional changes in the lung tissue. Treated patients are free from mycobacterium and considered cured, but the restoration of lungs function in these patients is also needed. Aims and Objectives: This study plans to evaluate and compare the pulmonary function test (PFT) parameters immediately, 3 months and 6 months after the completion of TB treatment and assess its severity. Materials and Methods: By convenient sampling, 118 voluntarily participated pulmonary TB-treated patients completing Category I regimen. PFT during three intervals after the completion of full course of antitubercular drugs was evaluated. Spirometry was done in sitting position according to the American Thoracic Society (ATS) recommendation and interpretation of the results was done. Results: Male-to-female proportion of the pulmonary TB patients was 56.8% versus 43.2%, respectively, within 22-65 years. Maximum patients, that is, 39% were within 31-40-year-age group. Immediate after completion of the treatment, 7.6% had symptoms of exertion dyspnea which were not on follow-up visits. The percent predictive values of the PFT were marginally above the impairment values. There was statistically significant difference mean forced vital capacity (FVC) (P < 0.001), forced expiratory volume at one second/FVC ratio percentage (P < 0.01), peak expiratory flow rate (P < 0.05), and maximal voluntary ventilation (P < 0.01) at the three intervals. Pulmonary function results were normal in 89.8% of patients immediately after the completion of TB treatment, in 91.5% at 3 months and 88.1% at 6 months. Impaired pulmonary function values were in 10.2% of patients at immediate, 8.5% at 3 months, and 11.9% patients at 6 months after completion of TB treatment. The 6-month PFT findings in 6.8% had obstructive changes, 3.4% had restrictive, and 1.7% with mixed PFT changes. Conclusion: There is the presence of pulmonary functional limitations in Category I TB-treated patients. Values for PFT were still lower in few patients even after completion of 6 months of treatment for Category I pulmonary TB.

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Association of Mortality and Years of Potential Life Lost With Active Tuberculosis in the United States

et al. 2020

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Pulmonary Impairment After Tuberculosis

Cited by 192 publications

References 17 publications

Evaluation of respiratory impairment and health related quality of life in pulmonary tuberculosis sequelae patients

Evaluation of respiratory impairment and health related quality of life in pulmonary tuberculosis sequelae patients

A six-month follow-up study to evaluate changes of pulmonary function test in Category I pulmonary tuberculosis treatment completed patient

Association of Mortality and Years of Potential Life Lost With Active Tuberculosis in the United States

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