Pulmonary Immunoglobulin Responses to<i>Streptococcus pneumoniae</i>Are Altered but Not Reduced in Human Immunodeficiency Virus–Infected Malawian Adults

Gordon, Stephen B.; Miller, David E.; Day, Richard B.; Ferry, Tristan; Wilkes, David S.; Schnizlein-Bick, Carol T.; Zijlstra, Eduard E.; Read, Robert C.; Molyneux, Malcolm E.; Twigg, Homer L.

doi:10.1086/377480

Cited by 27 publications

(31 citation statements)

References 15 publications

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“…Consistent with the concept of repertoire expansion, a correlation between the bronchoalveolar lavage (BAL) VL and higher levels of PS-specific IgG in BAL fluid in HIV þ /IPD þ than HIV þ /IPD 2 individuals has been reported. 35 In contrast, our finding of an inverse relationship between IgM V H 3 expression and VL only in HIV þ /IPD þ children led us to hypothesize that the susceptibility of certain HIV þ children to IPD could reflect a further decline in the physiological IgM deficiency of infancy and young childhood. 31 These hypotheses can be investigated with prospective studies of the relationship between V H 3 expression and development of pneumococcal disease in HIV þ and HIV 2 children.…”

Section: Discussionmentioning

confidence: 76%

VH3 gene expression in children with HIV infection

Chang¹

2004

Journal of Infection

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Section: Discussionmentioning

confidence: 76%

VH3 gene expression in children with HIV infection

Chang¹

2004

Journal of Infection

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“…HIV infection results in increased numbers of activated circulating B cells producing non-specific IgG [20] likely driven by an altered cytokine milieu [21]. High immunoglobulin concentrations are found in the lung of HIV-infected subjects [22,23]. However, the antibody that is produced appears to have defective opsonic function, including activity against pneumococcus [24,25].…”

Section: Effect Of Hiv On Pulmonary Immune Responsesmentioning

confidence: 99%

HIV-related lung disorders

Twigg

Knox

2007

Drug Discovery Today: Disease Mechanisms

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Highly active antiretroviral therapy (HAART) has dramatically altered the spectrum of morbidity and mortality in HIV-infected patients. This has been attributed to improvements in the lung microenvironment leading to enhanced pulmonary immunity, either by preventing the progressive loss of immune function or by actually promoting immune restoration. However, these changes have been accompanied by the recognition of new pulmonary complications in HIV-infected subjects, especially those associated with immune reconstitution. In this review we will describe how HIV infection alters the normal pulmonary environment, highlight the effect of HAART on these perturbations, and discuss potential complications of HAART in the lung, focusing on the pulmonary immune reconstitution inflammatory syndrome.

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“…However, those with a history of pneumonia did not have higher levels of antibodies to pneumococcal polysaccharides, and levels of antibodies to GXM and pneumococcal polysaccharides were not correlated. HIV-infected African children with acute pneumonia and adults with pneumococcal pneumonia had high levels of IgM and IgG (32,46). Although pneumococcus was the causative agent in 46% of Kenyans with pneumonia with an identified etiology (58) and 30% of Ugandans (66), the etiology of most cases of pneumonia in Africans is unknown.…”

Section: Deficiency Of Cd27mentioning

confidence: 99%

Cryptococcus neoformans -Reactive and Total Immunoglobulin Profiles of Human Immunodeficiency Virus-Infected and Uninfected Ugandans

Subramaniam¹,

French

Pirofski

2005

Clin Vaccine Immunol

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We determined total and Cryptococcus neoformans glucuronoxylomannan (GXM)-reactive antibody repertoires of human immunodeficiency virus (HIV)-infected and HIV-uninfectedThe results showed that HIV-infected subjects had significantly lower levels of IgM to GXM but higher levels of total immunoglobulin and IgG and IgA to GXM than those of HIV-uninfected subjects. HIV-infected subjects with a history of pneumonia had higher levels, and those with a history of herpes zoster had lower levels of GXM-binding antibodies than subjects with no history of either disease. Minimal to no cross-reactivity was demonstrated between antibodies to GXM and polysaccharides in a pneumococcal vaccine. No significant differences between the antibody repertoires of HIV ؉ CM ؉ and HIV ؉ CM ؊ subjects were identified, but among subjects without a history of pneumonia, there was a trend towards lower V H 3-positive antibody levels among HIV ؉ CM ؉ than among HIV ؉ CM ؊ subjects. Our findings demonstrate an association between previous infectious diseases and differences in the total and GXM-reactive antibody repertoires of HIV-infected subjects and suggest the question of whether certain microbes modulate subsequent antibody responses to GXM deserves further study.

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Pulmonary Immunoglobulin Responses toStreptococcus pneumoniaeAre Altered but Not Reduced in Human Immunodeficiency Virus–Infected Malawian Adults

Cited by 27 publications

References 15 publications

VH3 gene expression in children with HIV infection

VH3 gene expression in children with HIV infection

HIV-related lung disorders

Cryptococcus neoformans -Reactive and Total Immunoglobulin Profiles of Human Immunodeficiency Virus-Infected and Uninfected Ugandans

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