Pulmonary hypoplasia in babies with severe rhesus isoimmunisation: A quantitative study

Chamberlain, David G.; Hislop, Alison A.; Hey, Edmund; Reid, Lynne

doi:10.1002/path.1711220108

Cited by 46 publications

(5 citation statements)

References 22 publications

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“…PH was also demonstrated in some instances of hydrops fetalis, as reported by Chamberlain et al (1977), and may have been caused by the thoracic space-occupying effects of large pleural effusions and raising of the diaphragm by tense ascites and gross hepatosplenomegaly. It is suggested that a similar mechanism exists that raises the diaphragm in PH associated with ascites in meconium peritonitis.…”

Section: Discussionmentioning

confidence: 68%

Pulmonary hypoplasia: lung weight and radial alveolar count as criteria of diagnosis.

Askenazi¹,

Perlman²

1979

Archives of Disease in Childhood

293

146

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SUmmARY A working definition of pulmonary hypoplasia (PH) was established by retrospective assessment of lung growth both in recognised and hypothetical PH-associated conditions. Lung weight: body weight ratios (LW:BW) were calculated, and morphometry was determined by the radial alveolar count (RAC) (Emery and Mithal, 1960). Both parameters were reduced compared with those of normal controls in diaphragmatic hernia, anencephalus, anuric renal anomalies, chondrodystrophies, and osteogenesis inperfecta. Comparison of LW:BW ratio and RAC indicated that the RAC was the more reliable criterion of PH, LW:BW ratio of .0-012 (67% of mean normal ratio) and/or RAC of < 4.1 (75 % of mean normal count) are suggested as diagnostic criteria of PH. Evidence of PH was incidentally discovered in a number of clinically unsuspected cases and retrospectively clarified the clinical and radiological findings. Routine assessment of lung growth should be an essential part of the neonatal necropsy.

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Section: Discussionmentioning

confidence: 68%

Pulmonary hypoplasia: lung weight and radial alveolar count as criteria of diagnosis.

Askenazi¹,

Perlman²

1979

Archives of Disease in Childhood

293

146

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“…The latter has been expressed in an increased medial wall thickness as percentage of the external thickness 15,16 . Peripheral extension of muscle into arteries smaller than normal have been observed 7,9,15,16 and the intrapulmonary arteries are smaller than normal but appropriate for the reduced volume of the lung 7,9 . These features form the morphologic basis for the increased pulmonary vascular resistance.…”

Section: Abnormal Lung Development: Pulmonary Hypoplasia Definition Amentioning

confidence: 99%

The fetal lung 2: pulmonary hypoplasia

Laudy

Wladimiroff

2000

Ultrasound in Obstet & Gyne

139

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This review describes the pathogenesis of pulmonary hypoplasia and highlights its clinical, radiological and pathologic features, with emphasis on oligohydramniosrelated pulmonary hypoplasia. Since pulmonary hypoplasia may lead to severe respiratory distress immediately after birth and even to neonatal death, an accurate and patient-friendly prenatal test for early detection and distinction between lethal and non-lethal pulmonary hypoplasia is still highly desirable. An extended overview of the proposed methods for the prenatal prediction of pulmonary hypoplasia is presented.

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“…Lung growth can also be impaired by a direct immune mediated injury [10]. Low lung volumes were noted in infants whose mothers underwent their ®rst invasive procedure prior to 24 weeks of gestation [17]; the pulmonary abnormality at follow-up might, therefore, re¯ect the severity of the fetal condition [10] and/or indicate that the invasive procedures were carried out at a critical stage of lung growth.…”

Section: Morbiditymentioning

confidence: 99%

Rhesus disease: postnatal management and outcome

Greenough¹

1999

European Journal of Pediatrics

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The incidence of rhesus haemolytic disease has been markedly reduced. Affected infants who have had intrauterine transfusions suffer a late hyporegenerative anaemia. Postnatal haemolysis and hence treatment for hyperbilirubinaemia is less commonly needed. Optimal phototherapy reduces the need for postnatal exchange transfusions, but data on the efficacy of inhibitors of bilirubin production such as haem oxygenase inhibitors or immunoglobulin are less secure. Even hydropic infants have less than 20% mortality and bilirubin encephalopathy is uncommon. There is, however, very limited information on the long-term outcome of infants with rhesus haemolytic disease. Multicentre collaboration is required to test strategies to improve the management of affected individuals further and to provide meaningful data on their prognosis.

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Pulmonary hypoplasia in babies with severe rhesus isoimmunisation: A quantitative study

Cited by 46 publications

References 22 publications

Pulmonary hypoplasia: lung weight and radial alveolar count as criteria of diagnosis.

Pulmonary hypoplasia: lung weight and radial alveolar count as criteria of diagnosis.

The fetal lung 2: pulmonary hypoplasia

Rhesus disease: postnatal management and outcome

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