Pulmonary hypertension in schistosomiasis mansoni

Lambertucci, José Roberto; Carvalho, Vinicius Tostes; Silva, Luciana Cristina dos Santos

doi:10.1590/s0037-86822006000300016

Cited by 6 publications

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“…Schistosomal pulmonary hypertension is diagnosed in approximately 10% of the patients with hepatosplenic schistosomiasis [48][49][50][51] ; the use of pulmonary vasodilators has greatly improved the survival and quality of life of those patients [52][53][54][55] .…”

Section: Complications Of Hepatosplenic Schistosomiasismentioning

confidence: 99%

Revisiting the concept of hepatosplenic schistosomiasis and its challenges using traditional and new tools

Lambertucci

2014

Rev. Soc. Bras. Med. Trop.

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Different aspects of hepatosplenic schistosomiasis are revisited here. Manson's schistosomiasis causes periportal fi brosis and portal hypertension in approximately 6% of infected subjects, usually with preservation of their hepatic function. The assessment of liver involvement is of major importance in determining the prognosis and risk of complications from schistosomiasis, such as upper digestive bleeding secondary to variceal rupture. For many years, the diagnosis of hepatosplenic schistosomiasis and liver fi brosis was made by abdominal palpation and the fi nding of liver and/or spleen enlargement. However, there is no consensus regarding the clinical parameters of the liver and spleen to be considered in this physical evaluation. For the last three decades, abdominal ultrasound (US) has become the best imaging technique to evaluate liver fi brosis caused by schistosomiasis mansoni. However, US is a subjective procedure and is therefore examiner-dependent. Magnetic resonance imaging (MRI) fi ndings have provided valuable information in addition to ultrasound and clinical examination. The combination of a comprehensive history and physical examination, basic laboratory tests (a stool examination for Schistosoma mansoni eggs and a blood cell count), biomarkers for liver fi brosis/portal hypertension and imaging methods seem to offer the best approach for evaluating patients with this disease. In situations where research is involved or in patients with severe disease, MRI may be considered.

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Section: Complications Of Hepatosplenic Schistosomiasismentioning

confidence: 99%

Revisiting the concept of hepatosplenic schistosomiasis and its challenges using traditional and new tools

Lambertucci

2014

Rev. Soc. Bras. Med. Trop.

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“…AA, Teixeira R, Nobre V, et al and cardiomegaly due to right ventricular enlargement. (17,18) The case described here illustrates two relevant points. The first is related to the adoption of recommendations made in clinical guidelines.…”

Section: Discussionmentioning

confidence: 92%

Tratamento da hipertensão pulmonar esquistossomótica

et al. 2011

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The current classification includes five groups, and Group I (pulmonary arterial hypertension-PAH) is defined as a resting mean pulmonary artery pressure ≥ 25 mmHg, plus values < 15 mmHg for pulmonary artery wedge pressure and left ventricular end-diastolic pressure, or left atrial pressure. Clinically, PH syndrome manifests as dyspnea, oppressive chest pain, or syncope on exertion; radiologically, it manifests as dilatation of the pulmonary arteries and trunk; and, echocardiographically, it manifests as increased IntroductionPulmonary hypertension (PH) syndrome is a heterogeneous group of conditions that have one common feature: pulmonary artery involvement, characterized by remodeling of the intimal and medial vascular layers, with a consequent increase in pulmonary vascular resistance, hypertrophy, and right ventricular dilatation, which can lead to significant cardiac dysfunction (cor pulmonale) and death.(1-3) Currently, PH is defined as a resting mean pulmonary artery pressure equal to or greater than 25 mmHg, as measured by right heart Treatment of schistosomiasis-associated pulmonary hypertension* people (4.6%) suffer from pulmonary arterial hypertension, which is associated with the hepatosplenic form of the disease. This high prevalence makes schistosomiasis-associated pulmonary hypertension the leading cause of pulmonary hypertension worldwide. However, no specific treatment for the pulmonary vascular component of the disease has yet been devised. We report the case of a patient with schistosomiasis-associated pulmonary hypertension who was treated satisfactorily with a phosphodiesterase-5 inhibitor (sildenafil).Keywords: Schistosomiasis mansoni; Hypertension, pulmonary; Drug therapy. ResumoA esquistossomose mansoni é a terceira doença parasitária endêmica mais prevalente do mundo. Estima-se que mais de 200 milhões de pessoas estejam infectadas com uma das espécies do parasita Schistosoma. Dessas, 270.000 pessoas (4,6%) são portadoras de hipertensão arterial pulmonar, que é associada à forma hepatoesplênica da doença. Essa alta prevalência coloca a hipertensão pulmonar esquistossomótica como a causa mais frequente de hipertensão pulmonar no mundo. Entretanto, o tratamento dirigido especificamente ao acometimento vascular pulmonar não está ainda estabelecido. Relatamos o caso de uma paciente portadora dessa doença que foi tratada com um inibidor de fosfodiesterase-5 (sildenafil) com resultados satisfatórios.

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“…Clinical manifestations as well as complications depend on the species but also on the stage and duration of infestation [4]. It is described that the Mansoniform, with digestive tropism, is rather responsible for PH [18] [19]. This complication constitutes the most known cardio-vascular disease of Schistosomiasis.…”

Section: Discussionmentioning

confidence: 99%

Characteristics of the Heart of School-Age Children in a Schistosomiasis Endemic Area in Senegal

Sarr¹,

Camara²,

Hicham³

et al. 2018

WJCD

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Introduction: In Senegal, surveys have revealed areas of high endemicity of Schistosomiasis including the town of Richard Toll. We undertook this study to determine the echocardiocardiographic characteristics of school-age children in endemic bilharziasis. Methodology: We performed a descriptive cross-sectional study in Richard Toll and Dakar in school-age children. Results: A total of 250 children were included. There was male predominance, age between 4 and 16 (10 years old ± 2.77). Hematuria was reported in 69.6% of cases in endemic areas. Positive testing for Schistoma haematobium was found exclusively in Richard-Toll at 33.5%. The diastolic, systolic, basal and median left ventricle dimensions were larger in Richard Toll's population compared to Dakar. It was the same for the right chambers dimensions. The average pulmonary systolic arterial pressure was greater in Richard-Toll: 26.38 ± 3.16 mmHg versus 21.82 ± 1.73 mmHg in Dakar (p < 0.001). There was a correletion between pulmonary systolic artérial pressure and presence of hematuria, anemia and parasitological positivity. Conclusion: The heart of the school-aged child in endemic area is characterized by larger cavitary dimensions.

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Pulmonary hypertension in schistosomiasis mansoni

Cited by 6 publications

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Revisiting the concept of hepatosplenic schistosomiasis and its challenges using traditional and new tools

Revisiting the concept of hepatosplenic schistosomiasis and its challenges using traditional and new tools

Tratamento da hipertensão pulmonar esquistossomótica

Characteristics of the Heart of School-Age Children in a Schistosomiasis Endemic Area in Senegal

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