Pulmonary hypertension in late onset neonatal sepsis using functional echocardiography: a prospective study

Deshpande, Sujata; Suryawanshi, Pradeep; Holkar, Shrikant; Singh, Yogen; Yengkhom, Rameshwor; Klimek, Jan; Gupta, Samir

doi:10.1007/s40477-021-00590-y

Cited by 6 publications

(2 citation statements)

References 31 publications

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“…Release in the bloodstream of bacterial endotoxins, together with inflammatory mediators (including endothelin-1 and thromboxane, which constitute potent vasoconstrictors) and various cytokines, seem to contribute to the pathophysiology of PPHN associated with neonatal sepsis. [ 37 , 38 ] Additionally, although S. gallolyticus has been clearly linked with cases of endocarditis in adult patients, to our knowledge, only one case has been reported in the neonatal population; this patient recovered without sequelae [ 20 ]. The overall prognosis is encouraging, with three neonatal deaths by S. gallolyticus being recorded in the literature out of 67 cases of neonatal infection (including one extremely premature and extremely low birth weight neonate) and 2 cases complicated by severe neurologic sequelae [ 2 , 17 , 25 , 26 ].…”

Section: Discussionmentioning

confidence: 99%

Neonatal Sepsis Caused by Streptococcus gallolyticus Complicated with Pulmonary Hypertension: A Case-Report and a Systematic Literature Review

et al. 2022

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Streptococcus gallolyticus (S. gallolyticus) has been linked to the development of infections in adults; however, in neonates S. gallolyticus sepsis is very rare and resembles Group B Streptococcal infections. In this case report, we present the case of a full-term neonate who developed early-onset sepsis due to S. gallolyticus. A systematic review of the literature was also conducted. The neonate had good APGAR scores at 1′ and 5′. At 5 h postnatally, the neonate developed poor feeding and respiratory distress. She received oxygen in a head box, and a complete blood count and biochemistry, blood, CSF and body surface cultures were obtained. Empiric intravenous antibiotics (ampicillin and tobramycin) were initiated, and she was transferred to a tertiary NICU for further treatment. The neonate was mechanically ventilated and received dopamine and colloid fluids for circulatory support. A cardiology consultation revealed pulmonary hypertension on day one. S. gallolyticus was isolated in the blood culture. Central nervous system ultrasonography, brainstem auditory evoked potentials, and a second cardiology evaluation were normal on day three. Clinical and laboratory improvement was noted on day three, and the baby was discharged after a 12-day hospitalization. Follow-up visits were scheduled for reevaluation.

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Section: Discussionmentioning

confidence: 99%

Neonatal Sepsis Caused by Streptococcus gallolyticus Complicated with Pulmonary Hypertension: A Case-Report and a Systematic Literature Review

et al. 2022

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“…NPE is an important tool for confirming the diagnosis and grading of PPHN, objective selection of specific therapies, and titrating and monitoring response to treatment. Specific protocols are available for assessing PH related to bronchopulmonary dysplasia [9,10], late onset sepsis [11], and congenital diaphragmatic hernia [12,13]. The aim of this article is to provide guidance to neonatologists undertaking fECHO examinations of newborn infants suspected of having PH to assist with diagnosis and management.…”

Section: Introductionmentioning

confidence: 99%