Pulmonary hypertension in interstitial lung disease: Clinical trial design and endpoints: A consensus statement from the Pulmonary Vascular Research Institute's Innovative Drug Development Initiative—Group 3 Pulmonary Hypertension
Abstract:Pulmonary hypertension (PH) associated with interstitial lung disease (ILD) is an attractive target for clinical trials of PH medications. There are many factors that need to be considered to prime such studies for success. The patient phenotype most likely to respond to the intervention requires weighing the extent of the parenchymal lung disease against the severity of the hemodynamic impairment. The inclusion criteria should not be too restrictive, thus enabling recruitment. The trial should be of sufficien… Show more
“…53 While recent guidelines allow for consideration of PAH therapy in patients with lung disease and PVR > 5 WU, cumulatively, our results and those previously published highlight the importance of prospective studies, particularly within subgroups enriched for treatment response, possibly with multicomponent endpoints. 54,55 Finally, our study highlights the importance of endpoints that capture clinical deterioration including morbidity and mortality and is the first to examine long-term treatment effects within Group 3 PH subgroups. 32,55…”
BackgroundClinical trials repurposing pulmonary arterial hypertension (PAH) therapies to patients with lung disease- or hypoxia-pulmonary hypertension (Group 3 PH) have failed to show a consistent benefit. However, Group 3 PH clinical heterogeneity suggests robust phenotyping may inform detection of treatment-responsive subgroups. We hypothesized that cluster analysis would identify sub-phenotypes with differential responses to oral PAH therapy.MethodsTwo k-means analyses were performed on a national cohort of U.S. Veterans with Group 3 PH; an inclusive model (I) of all treated patients (n=196) and a hemodynamic model (H) limited to patients with right heart catheterisations (RHC) (n=112). The primary outcome was organ failure or all-cause mortality by cluster. An exploratory analysis evaluated within-cluster treatment effects.ResultsThree distinct clusters of Group 3 PH patients were identified. In the “inclusive model” (C1I=43, 21.9%; C2I=102, 52.0%; C3I=51, 26.0%) lung disease and spirometry drove cluster assignment whereas RHC data surpassed the importance of these variables in the hemodynamic model (C1H=44, 39.3%; C2H=43, 38.4%; C3H=25, 22.3%). In the hemodynamic model, compared to C3H, C1Hexperienced the greatest hazard for respiratory failure or death (HR 6.1 [95% CI 3.2, 11.8]). In an exploratory analysis, cluster determined treatment response (p=0.006). Conclusions regarding within-cluster treatment responses were limited by significant differences between select variables in the treated and untreated groups.ConclusionsCluster analysis identifies novel real-world sub-phenotypes of Group 3 PH patients with distinct clinical trajectories. Future studies may consider this methodologic approach to identify subgroups of heterogeneous patients that may be responsive to existing pulmonary vasodilatory therapies.
“…53 While recent guidelines allow for consideration of PAH therapy in patients with lung disease and PVR > 5 WU, cumulatively, our results and those previously published highlight the importance of prospective studies, particularly within subgroups enriched for treatment response, possibly with multicomponent endpoints. 54,55 Finally, our study highlights the importance of endpoints that capture clinical deterioration including morbidity and mortality and is the first to examine long-term treatment effects within Group 3 PH subgroups. 32,55…”
BackgroundClinical trials repurposing pulmonary arterial hypertension (PAH) therapies to patients with lung disease- or hypoxia-pulmonary hypertension (Group 3 PH) have failed to show a consistent benefit. However, Group 3 PH clinical heterogeneity suggests robust phenotyping may inform detection of treatment-responsive subgroups. We hypothesized that cluster analysis would identify sub-phenotypes with differential responses to oral PAH therapy.MethodsTwo k-means analyses were performed on a national cohort of U.S. Veterans with Group 3 PH; an inclusive model (I) of all treated patients (n=196) and a hemodynamic model (H) limited to patients with right heart catheterisations (RHC) (n=112). The primary outcome was organ failure or all-cause mortality by cluster. An exploratory analysis evaluated within-cluster treatment effects.ResultsThree distinct clusters of Group 3 PH patients were identified. In the “inclusive model” (C1I=43, 21.9%; C2I=102, 52.0%; C3I=51, 26.0%) lung disease and spirometry drove cluster assignment whereas RHC data surpassed the importance of these variables in the hemodynamic model (C1H=44, 39.3%; C2H=43, 38.4%; C3H=25, 22.3%). In the hemodynamic model, compared to C3H, C1Hexperienced the greatest hazard for respiratory failure or death (HR 6.1 [95% CI 3.2, 11.8]). In an exploratory analysis, cluster determined treatment response (p=0.006). Conclusions regarding within-cluster treatment responses were limited by significant differences between select variables in the treated and untreated groups.ConclusionsCluster analysis identifies novel real-world sub-phenotypes of Group 3 PH patients with distinct clinical trajectories. Future studies may consider this methodologic approach to identify subgroups of heterogeneous patients that may be responsive to existing pulmonary vasodilatory therapies.
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