Pulmonary Hypertension and Left Heart Function: Insights from Tissue Doppler Imaging and Myocardial Performance Index

Abstract

The result infers that the systolic and diastolic function of LV declined, following pulmonary hypertension.

Lung neovascularity in pulmonary arterial hypertension associated with congenital heart defects and idiopathic pulmonary arterial hypertension: study of 198 patients

“…Besides, it is conceivable that, in patients with more severe PH, aortic size can diminish, due to a corresponding reduction in cardiac output [15].…”

Chronic pulmonary hypertension shortens the duration of mitral annular systolic and diastolic tissue doppler signals

“…Recent data, using MPI, have suggested that alterations in both LV systolic and diastolic function occur as a result of cPH [31]. Specifically, prolongation of the LV-IVRT interval, indicative of LV diastolic dysfunction, has been shown in patients with moderate or worse degrees of cPH, irrespective of their PH etiology [31]; as well as evidence of global LV systolic and diastolic impairment in patients with Fig. 3 Box plot showing differences between Group I and II with regards to heart rate corrected duration of mitral annular systole and diastole chronic obstructive pulmonary disease with PH [13].…”

“…Furthermore, these conformational changes in terms of both RV hypertrophy and dilatation are thought to impair LV distensibility, causing LV diastolic dysfunction [10]. Recent data, using MPI, have suggested that alterations in both LV systolic and diastolic function occur as a result of cPH [31]. Specifically, prolongation of the LV-IVRT interval, indicative of LV diastolic dysfunction, has been shown in patients with moderate or worse degrees of cPH, irrespective of their PH etiology [31]; as well as evidence of global LV systolic and diastolic impairment in patients with Fig.…”

Current pathophysiological concepts and management of pulmonary hypertension

“…Experimental findings and clinical observations suggest that elevated mPAP cannot be the single driver for RV failure [62], therefore, targeting the RV may be a promising approach [6]. As for the LV myocardium, echocardiography shows compromised LV function in various aetiologies of PH [67], mainly due to ventricular interdependence and impaired filling [68]. Nevertheless, myocardial abnormalities partly underlie LV dysfunction.…”