Pulmonary hypertension and echocardiogram parameters in obstructive sleep apnea

Abstract

Obstructive sleep apnea (OSA) is a growing health hazard in the United States and worldwide. OSA is now recognized as a disorder with systemic manifestations and its association with obesity and adverse cardiovascular consequences. There is increasing evidence that OSA may be associated with systemic hypertension and an increased incidence of stroke, heart failure, myocardial infarction, and arrhythmias. Less information is available about the association between OSA and pulmonary hypertension (PH). We therefore conduct this study to look at the prevalence of the pulmonary hypertension in obstructive sleep apnea patient and to identify risk factors leading to pulmonary hypertension among OSA patient. We studied and analyzed all OSA patient confirmed by polysomnograph in the year 2015. Twenty-five patients with OSA were included in this study with prevalence of pulmonary hypertension of 16%. Univariate analysis of various factors revealed a statistically significant association between having the lowest SpO of <70% and pulmonary hypertension (p = 0.016). There were no statistically significant associations between age, gender, smoking status, hypertension, body mass index (BMI), or apnea-hypopnea index (AHI) with occurrence of pulmonary hypertension. AHI is not a good predictor for pulmonary hypertension. The real value of using AHI to predict the health risk of OSA is doubtful. We recommend routine echocardiogram among OSA patient. The objective information in the echocardiogram provides evidence for counseling of patient with disease of OSA and hence hopefully can improve compliance of patient to treatment especially usage of CPAP.

Additive effects of orchiectomy and intermittent hypoxia on lung mechanics and inflammation in C57BL/6J male mice

“…Because these can be early signs of more concerning alterations of lung functions such as emphysema and COPD, further experiments should be pursued to better understand these interactions. Given that low testosterone levels are commonly encountered in male patients suffering from SA (Kim & Cho, 2019) as well as in various forms of respiratory diseases (Atlantis et al., 2013; Han et al., 2020), including asthma and COPD and with the rising concerns that SA could contribute to the establishment or progression of lung diseases (Gille et al., 2017; Kong et al., 2017; Nisbet et al., 2009; Owens et al., 2017; Prasad et al., 2020; Teodorescu et al., 2015; H. S. Wong, et al., 2017; H. T. Wong et al., 2017; Yigla et al., 2003), the clinical relevance of such studies is clearly important.…”

“…Since inflammation and oxidative stress are also important contributing factors to common respiratory diseases, concerns regarding the association between SA and chronic obstructive pulmonary disease (COPD) (Owens et al., 2017), asthma (Kong et al., 2017; Prasad et al., 2020; Teodorescu et al., 2015; Yigla et al., 2003), idiopathic pulmonary fibrosis (IPF) (Gille et al., 2017) and pulmonary arterial hypertension (Nisbet et al., 2009; H. S. Wong et al., 2017; H. T. Wong et al., 2017) are rising. Furthermore, CPAP therapy reduces mortality in apnoeic patients also suffering from COPD (Owens & Malhotra, 2010; Owens et al., 2017) and improves the quality of life in apnoeic patients with IPF (Mermigkis et al., 2015) and asthma (Prasad et al., 2020), thus supporting a link between IH and the development of respiratory diseases.…”

Prehabilitation of Cardiac Surgical Patients, Part 1: Anemia, Diabetes Mellitus, Obesity, Sleep Apnea, and Cardiac Rehabilitation

“…93 A recent meta-analysis validated this screening tool for OSA, and showed a strong negative predictive value at excluding severe OSA with scores less than 2. 94 As OSA is associated with pulmonary hypertension and subsequent right heart dysfunction, practitioners should have a very low screening threshold for preoperative transthoracic echocardiography in patients with known or suspected OSA, 95 although these studies should be available or obtained in routine pre-surgical workup in this patient population.…”

The Effect of Light on Quality of Sleep and Life in Breast Cancer Patients

“…Bu nedenle çalışmamızda OHS olgularında sağ kalp fonksiyonları ile ilişkili ekokardiyografik parametreleri [sağ ventrikül çapı, pulmoner velosite, triküspit anüler düzlem sistolik hareketi (TAPSE), sistolik pulmoner arter basıncı (PABs)] ve PH sıklığını araştırmayı ve bu sonuçları obez saf OUAS olguları ile karşılaştırmayı amaçladık. Yapılan araştırmalarda OUA'da PH sıklığının OHS'ye göre daha düşük (%16-42) olduğu ve PAB'nın hafif yükselmiş olabileceği belirtilmiştir (11,(19)(20)(21)(22)(23)(24)(25). Yalnız bir çalışmada OUA'da PH sıklığı çok yüksek (%73) olarak bildirilmiştir.…”