Pulmonary Hyalinosis in Dogs

Dagle, G.E.; Filipy, R.E.; Adee, R.R.; Stuart, B.O.

doi:10.1177/030098587601300208

Cited by 8 publications

(5 citation statements)

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“…5 The other study found lesions in 30 of 34 beagles exposed to airborne radon daughters (radioactive decay particles) with uranium ore dust and attributed the material to a degenerative response to injury with accumulation of endogenous secretions. 10 All but 1 of the affected EIII/JC described here were unmanipulated breeders, with no known airborne exposures (no history provided for the exception). Only 1 rabbit had upper airway disease potentially causing obstruction.…”

Section: Discussionmentioning

confidence: 99%

Spontaneous Lung Lesions in Aging Laboratory Rabbits (Oryctolagus cuniculus)

et al. 2016

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Spontaneous age-related lesions of laboratory rabbits are not well documented in the contemporary scientific literature. A retrospective study of diagnostic necropsies of 36 rabbits >2 years of age found a number of common lung lesions. Fibromuscular intimal hyperplasia affected medium and to a lesser extent large pulmonary arteries and was present to a variable extent in all 36 rabbits >2 years of age. The lesions were characterized by fragmentation and/or reduplication of the internal elastic lamina (IEL), proliferation of smoothelinþ/alpha-smooth muscle actin (a-SMA)þ/vimentinÀ smooth muscle cells and fewer smoothelinÀ/a-SMAþ/vimentinþ myofibroblasts, and intimal deposition of collagen without thrombosis, embolism, or evidence of pulmonary hypertension. Pulmonary emphysema, present in 30/36 rabbits, was characterized by the loss of alveolar septa; most affected rabbits did not have clinical signs of respiratory disease. In 8/13 rabbits of the inbred EIII/JC audiogenic strain, we identified a unique syndrome of granulomatous pneumonia containing hyaline brown to gray, globular to ring-like acellular material that was Alcian blue and periodic acid-Schiff positive. The material was immunoreactive for surfactant protein-A and had the ultrastructural appearance of multilamellar vesicles, suggesting a genetic defect in surfactant metabolism. Additionally, we found small benign primary lung tumors (fibropapillomas, 5 rabbits) not previously described. Other findings included heterotopic bone (5 rabbits), subacute to chronic suppurative bronchopneumonia, pyogranulomatous pneumonia with plant material, and pulmonary artifacts from barbiturate euthanasia solution.Although spontaneous background lesions of aging laboratory mice and rats are well documented and described, 7,9,19,23,31 there is less information on spontaneous lesions of aging laboratory rabbits. 14,15,21 In part this is because of the types of acute or relatively short-term studies for which rabbits are commonly used. In some cases where age-related lesions are described, such as spontaneous pulmonary emphysema, 42 other more recent references are contradictory, based apparently on the lack of additional confirmatory reporting. 4,8 Other spontaneous age-related lesions, such as unique intimal proliferations in the pulmonary arteries, are poorly documented in the English language literature, 20 and can resemble iatrogenic lesions caused by experimental manipulation. 27 While most rabbits used in research are outbred New Zealand White (NZW) or Dutch-belted stock, inbred rabbits strains do exist, including the audiogenic (EIII/JC) strain. The inbred III/J parent rabbit strain was originally developed at the Jackson Laboratory in 1932 by Dr Paul B. Sawin using NZW rabbits from Dr William Ernest Castle. The audiogenic (EIII/J) substrain was selected for a predisposition to sound-induced seizures by Dr Richard R. Fox in 1961. 13 The strain came to Penn State Hershey in 1988 from the National Cancer Institute. 37 Rabbits have been used as an induced experimental...

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Section: Discussionmentioning

confidence: 99%

Spontaneous Lung Lesions in Aging Laboratory Rabbits (Oryctolagus cuniculus)

et al. 2016

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“…8), involving larger areas, were palpated at gross examination. Dagle et al (Da76) described a lesion similar to the pulmonary hyalinosis that occurred in the dogs of Groups 1 and 2 as cellular degradation because of its ultrastructural appearance. Vesicular emphysema was present in the lungs of all dogs from Groups 1 and 2.…”

Section: Group 3 (Cigarette Smoke Only)mentioning

confidence: 99%

Carcinogenic Effects of Radon Daughters, Uranium Ore Dust and Cigarette Smoke in Beagle Dogs

Ft¹,

Rf²,

Re³

et al. 1982

Health Physics

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The development of pulmonary lesions in beagle dogs was studied following chronic inhalation exposures to radon (at 105 % 20 nCi/l), radon daughters (at 605 k 169 WL), uranium ore dust (at 12.9 5 6.7 mglm') and cigarette smoke. Chronic exposures to mixtures of these agents caused significant lifespan shortening when compared with controls. Survival times of controls and smoke-exposed dogs were equivalent during the 4 to 5-yr mean survival time of the dogs exposed to radon-daughter and ore-dust mixtures (with or without added cigarette smoke).Animals with tumors of the respiratory tract generally had cumulative radon-daughter exposures exceeding 13,000 WLM, and their survival time was longer than the survival time of nontumor-bearing animals. Under the conditions of the experiment, exposure to cigarette smoke was found to have a mitigating effect on radon daughter-induced tumors. It is uncertain whether this would be a general finding applicable to other levels of exposure to radon daughters, uranium ore dust and cigarette smoke. tract lesions. However, exposure to 20 cigarettedd, 7 d/wk resulted in pulmonary emphysema, fibrosis and chronic bronchitis and bronchiolitis.Emphysema and fibrosis were much more prevalent and severe in the dogs exposed to mixtures which included radon daughters and uranium ore dust. These dogs also had adenomatous lesions which progressed to squamous metaplasia of aleveolar epithelium, epidermoid carcinoma and bronchioloalveolar carcinoma. Pathologic changes in the airways of these dogs were most prominent in the nasal mucosa, and included a few squamous carcinomas in the nasal cavity.We conclude that the beagle dog is a useful animal for modeling pulmonary lesions produced by uranium mine air contaminants. Tumors were produced at levels that did not greatly exceed some exposures reported for uranium miners. These tumors, found after approx. 50mo of exposure, might partially account for the absence of tumors in experiments where exposures terminated before 50 mo.

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“…3 Early descriptions suggested a response to inhalation or aspiration of irritants, including uranium ore dust. 4 Similar to other alveolar-filling disorders, abnormal alveolar hyaline material is thought to accumulate because of some combination of reduced bronchociliary clearance, excessive production, or impaired breakdown, typically by alveolar macrophages.…”

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“…The bodies also display birefringence under polarized light. 1,4 The inciting cause and pathogenesis for this accumulation of pulmonary hyaline material is unknown, but disease is seen predominantly in older dogs and typically is considered incidental. 3 Early descriptions suggested a response to inhalation or aspiration of irritants, including uranium ore dust.…”

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confidence: 99%

“…Pulmonary hyalinosis is an uncommon alveolar-filling disorder of dogs. 1,4 Alveolar-filling disorders are a group of overlapping conditions defined by the deposition of abnormal material within alveoli and include alveolar histiocytosis, endogenous lipid pneumonia, pulmonary alveolar proteinosis, pulmonary hyalinosis, and alveolar microlithiasis. Pulmonary hyalinosis in the dog is characterized by abnormal multifocal accumulations of basophilic-to-amphophilic, rounded hyaline bodies in alveoli and larger airways.…”

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Pulmonary hyalinosis in captive sugar gliders (Petaurus breviceps)

et al. 2017

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Pulmonary hyalinosis is an idiopathic, typically incidental lesion of old dogs, characterized by multifocal aggregates of epithelioid and multinucleate macrophages that surround periodic acid-Schiff (PAS)-positive hyaline material in airways. Lung lesions resembling pulmonary hyalinosis were observed in 6 captive adult sugar gliders ( Petaurus breviceps; 5 females and 1 male) in a retrospective review of 18 autopsied animals. Clinical signs for 3 of the sugar gliders included lethargy, tachypnea, and dyspnea. At autopsy, 5 of 6 animals had comorbid lesions that were the primary cause of death. Gross pulmonary lesions were characterized by mildly firm, discolored, vaguely nodular areas of parenchyma. Histologic examination of the lung revealed granulomatous inflammation with intracellular and extracellular amphophilic hyaline bodies within alveoli and airways. Hyaline bodies were positive for PAS and oil red O staining, blue via crystal violet staining, and displayed birefringence under polarized light, similar to findings in dogs with pulmonary hyalinosis.

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Pulmonary Hyalinosis in Dogs

Cited by 8 publications

References 4 publications

Spontaneous Lung Lesions in Aging Laboratory Rabbits (Oryctolagus cuniculus)

Spontaneous Lung Lesions in Aging Laboratory Rabbits (Oryctolagus cuniculus)

Carcinogenic Effects of Radon Daughters, Uranium Ore Dust and Cigarette Smoke in Beagle Dogs

Pulmonary hyalinosis in captive sugar gliders (Petaurus breviceps)

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