Pulmonary Hyalinizing Granuloma

Guccion, John G.; Rohatgi, Prashant K.; Saini, Nirmal

doi:10.1378/chest.85.4.571

Cited by 40 publications

(6 citation statements)

References 2 publications

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“…It has been proposed that the nodules may represent an abnormal immune response to infectious agents, such as tuberculous bacilli and histoplasma organisms, or autoimmune process, since many immune-mediated diseases appear in concordance with PHG [1, 2, 4, 5, 7, 8]. There have been reports of patients who were previously exposed to fungal or mycobacterial diseases prior to contracting PHG [6].…”

Section: Discussionmentioning

confidence: 99%

“…Congo red stain with polarization and crystal violet stain can be positive for amyloid, and the diagnosis of amyloidosis must be considered. Amyloidosis can be ruled out using electron microscopy because in PHG the hyaline lamellae consist of eletrondense, compact, amorphous material, which is substantially different from fibrillar amyloid lesions [4, 8]. …”

Section: Discussionmentioning

confidence: 99%

“…The exact etiology of this condition is unknown [2], although an exaggerated immune response to the antigenic stimuli by infection or autoimmune process has been suggested [3, 4]. The clinical presentation of PHG ranges from vague chest symptoms to no symptoms at all.…”

Section: Introductionmentioning

confidence: 99%

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Hyalinizing Granuloma: An Unusual Case of a Pulmonary Mass

Brandão

Marchiori

Zanetti

et al. 2010

Case Reports in Medicine

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We describe the case of pulmonary hyalinizing granuloma in a 34-year-old asymptomatic man who presented with a pulmonary nodule apparent by chest radiography and computed tomography (CT). He had a history of previous treatment for tuberculosis. His laboratory data were normal. Bronchoscopy and CT-guided percutaneous transthoracic fine needle aspiration cytology were inconclusive. The diagnosis was revealed after the histopathological examination of an open lung biopsy.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Hyalinizing Granuloma: An Unusual Case of a Pulmonary Mass

Brandão

Marchiori

Zanetti

et al. 2010

Case Reports in Medicine

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“…It was reported in adults between 19 and 77 yrs with no sex or racial predilection [1]. It has been postulated that it is a chronic exaggerated immune response to antigenic stimuli possibly by chronic granulomatous infections such as tuberculosis or histoplasmosis or autoimmune process [3,4].…”

Section: Discussionmentioning

confidence: 99%

Non-neoplastic Pulmonary Hyalinising Granuloma

Paluri¹,

Paranjape²,

Manne³

2018

JAMMR

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Pulmonary hyalinising granuloma (PHG) is a rare, benign and non-infectious pulmonary fibrosing lesion with unknown etiology. Fewer than 100 cases have been reported thus far. PHG can mimick advanced lung carcinoma and should therefore be a part of differential diagnosis for pulmonary nodule. It is characterized by whorled deposits of collagen and hyaline. Here we report the case of a 43 years old female who presented with dyspnea and constitutive symptoms. Imaging studies revealed bilateral pulmonary nodue and the histopathology consistent with PHG.

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“… 1 , 2 Solitary pulmonary nodules are rare. 3 , 4 Usually they grow slowly, or may not grow at all; spontaneous regression has also been reported. Positron emission tomography-CT may or may not reveal increased metabolic activity in PHG lesions, although it is useful in ruling out metastatic lesion.…”

Section: Discussionmentioning

confidence: 99%

Solitary pulmonary hyalinising granuloma: a rare cause of pulmonary nodule

2017

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A pulmonary nodule is a common incidental finding on chest imaging, which includes a wide variety of differential diagnosis. Pulmonary hyalinising granuloma is a rare disease aetiology of pulmonary nodule(s). We report a 74-year-old female who was referred to the respiratory clinic with incidental finding of a solitary pulmonary nodule on chest X-ray. CT confirmed the presence of a 1.2 cm solitary pulmonary nodule in the left upper lobe with no lymphadenopathy. The patient underwent wedge resection, and histopathological examination of the lesion confirmed pulmonary hyalinising granuloma. In most previously reported cases, patients had multiple lesions on chest radiography. Solitary pulmonary lesion is an uncommon presentation of this clinical entity and only a few cases have been reported in the literature.

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Pulmonary Hyalinizing Granuloma

Cited by 40 publications

References 2 publications

Hyalinizing Granuloma: An Unusual Case of a Pulmonary Mass

Hyalinizing Granuloma: An Unusual Case of a Pulmonary Mass

Non-neoplastic Pulmonary Hyalinising Granuloma

Solitary pulmonary hyalinising granuloma: a rare cause of pulmonary nodule

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