Pulmonary histopathology of interstitial lung disease associated with antisynthetase antibodies

Flashner, Bess M.; VanderLaan, Paul A.; Nurhussien, Lina; Rice, Mary B.; Hallowell, Robert W.

doi:10.1016/j.rmed.2021.106697

Cited by 5 publications

(2 citation statements)

References 69 publications

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“…Flashner et al collated all the reported histopathological reports of individuals with ASA-associated ILD allowing for a better overview of pathological patterns in ASyS. 102 NSIP remained the most prominent manifestation for patients with anti-Jo-1, anti-KS, and anti-EJ. Anti-PL12 patients had significantly more UIP pattern than other antibody profiles, and both anti-KS and anti-EJ patients were statistically least likely to have changes consistent with OP.…”

Section: Histopathologymentioning

confidence: 99%

Review of Pulmonary Manifestations in Antisynthetase Syndrome

Ghanbar,

Danoff

2024

Semin Respir Crit Care Med

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Antisynthetase syndrome (ASyS) is now a widely recognized entity within the spectrum of idiopathic inflammatory myopathies. Initially described in patients with a triad of myositis, arthritis, and interstitial lung disease (ILD), its presentation can be diverse. Additional common symptoms experienced by patients with ASyS include Raynaud's phenomenon, mechanic's hand, and fever. Although there is a significant overlap with polymyositis and dermatomyositis, the key distinction lies in the presence of antisynthetase antibodies (ASAs). Up to 10 ASAs have been identified to correlate with a presentation of ASyS, each having manifestations that may slightly differ from others. Despite the proposal of three classification criteria to aid diagnosis, the heterogeneous nature of patient presentations poses challenges. ILD confers a significant burden in patients with ASyS, sometimes manifesting in isolation. Notably, ILD is also often the initial presentation of ASyS, requiring pulmonologists to remain vigilant for an accurate diagnosis. This article will comprehensively review the various aspects of ASyS, including disease presentation, diagnosis, management, and clinical course, with a primary focus on its pulmonary manifestations.

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Section: Histopathologymentioning

confidence: 99%

Review of Pulmonary Manifestations in Antisynthetase Syndrome

Ghanbar,

Danoff

2024

Semin Respir Crit Care Med

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“…The main histological patterns identified are NSIP and OP. UIP and diffuse alveolar damage (DAD) are less frequently seen; one study has suggested that UIP is more common in anti-PL12 disease ( 39 ). Histopathological findings usually correlate with the HRCT pattern ( 40 ).…”

Section: Assessment Of Lung Diseasementioning

confidence: 99%

A multidisciplinary approach to the diagnosis of antisynthetase syndrome

et al. 2022

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Antisynthetase syndrome is a subtype of idiopathic inflammatory myopathy, strongly associated with the presence of interstitial lung disease. Diagnosis is made by identifying myositis-specific antibodies directed against aminoacyl tRNA synthetase, and relevant clinical and radiologic features. Given the multisystem nature of the disease, diagnosis requires the careful synthesis of subtle clinical and radiological features with the interpretation of specialized autoimmune serological testing. This is provided in a multidisciplinary environment with input from rheumatologists, respiratory physicians, and radiologists. Differentiation from other idiopathic interstitial lung diseases is key; treatment and prognosis differ between patients with antisynthetase syndrome and idiopathic interstitial lung disease. In this review article, we look at the role of the multidisciplinary team and its individual members in the initial diagnosis of the antisynthetase syndrome, including the role of physicians, radiologists, and the wider team.

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