Pulmonary Hemorrhage in the Neonate

Welde, Megan Alexandra; Sanford, Cassidy Brooke; Mangum, Melissa; Paschal, Christy

doi:10.1891/11-t-696

Cited by 14 publications

(9 citation statements)

References 35 publications

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“…In contrast, another study showed that no differences in moderate to severe BPD between pulmonary hemorrhage group and non-pulmonary hemorrhage group ( Previous study has de nitely shown that severe RDS and hemodynamically signi cant PDA (hsPDA) are triggers of pulmonary hemorrhage [22]. And the mechanism of pulmonary hemorrhage is mainly related to pulmonary congestion, pulmonary edema and pulmonary small vessel embolism [23]. Moreover, newborns with severe RDS and hsPDA often need longer invasive ventilation, which may increase the possibility of BPD.…”

Section: Discussionmentioning

confidence: 97%

Dose pulmonary hemorrhage increase the risk of bronchopulmonary dysplasia in very low birth weight infants?

Pan¹,

Tong

Wang

et al. 2022

Preprint

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Objective: To evaluate the association between pulmonary hemorrhage and bronchopulmonary dysplasia (BPD) in very low birth weight infants (VLBWIs). Methods: The study participants were all VLBW newborns admitted from January 1, 2019 to December 31, 2021. The finally included subjects were VLBWIs who survived to discharge. This study was divided into pulmonary hemorrhage group (PH group, n=33) and non-pulmonary hemorrhage group (Non-PH group, n=181). Results: By univariate analysis it was found that premature rupture of membranes, tracheal intubation in the delivery room, duration of mechanical ventilation, course of invasive ventilation (≥3 courses), pulmonary surfactant (>1 dose), medically and surgically treated patent ductus arteriosus, grade III-IV RDS, and early onset sepsis showed significant differences between groups (p<0.05). By univariate analysis, pulmonary hemorrhagedid not increase the risks of BPD and moderate to severe BPD. However, if the interference of invasive ventilation is excluded, pulmonary hemorrhage could increase the incidence of BPD (aOR=3.295, 95%CI1.183-9.179). Conclusion: Our data suggests that pulmonary hemorrhage is not associated with the development of BPD and moderate to severe BPD in VLBWIs.

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Section: Discussionmentioning

confidence: 97%

Dose pulmonary hemorrhage increase the risk of bronchopulmonary dysplasia in very low birth weight infants?

Pan¹,

Tong

Wang

et al. 2022

Preprint

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“…According to our present study and long-term clinical experience, a large pleural effusion in PH requires pleural puncture under ultrasound monitoring to drain the effusion, which can reduce patient's dyspnea and facilitate their recovery. Otherwise, the high mortality from PH is almost inevitable (3)(4)(5)(6). Among all the neonatal lung diseases, PH is the most difficult one to be diagnosed by ultrasound.…”

Section: Figurementioning

confidence: 99%

“…It was reported that the prevalence of neonatal PH was 6.7 for 1,000 live births, the rates observed were 8% among newborns <1,500 g, and 11% among newborns <1,000 g ( 3 ). Once PH occurs, the fatality rate can be increased as high as 56.25% ( 4 ), while the survivors also had a higher incidence of bronchopulmonary dysplasia (BPD), cerebral palsy and cognitive delay increased 2.5 times in premature infants with PH, and the incidence of severe periventricular leukomalacia also increased significantly ( 5 , 6 ). Early diagnosis and early treatment are the key to improve the prognosis of PH infants.…”

Section: Introductionmentioning

confidence: 99%

The specific signs of lung ultrasound to diagnose pulmonary hemorrhage of the newborns: Evidence from a multicenter retrospective case-control study

Liu

Chi

et al. 2023

Front. Pediatr.

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ObjectivesPulmonary hemorrhage (PH) is one kind of critical lung diseases in newborn infants, which is the most difficult one to be diagnosed by ultrasound. This study was to investigate the specific ultrasonic signs of PH in order to better diagnose neonatal PH by using lung ultrasound (LUS).MethodsA total 168 newborn infants were enrolled in this study, which included PH, pneumonia, meconium aspiration syndrome, and newborns without lung diseases, there were 42 cases in each group. In a quiet state, infants were placed in the supine, lateral or prone position for the examination. Each lung was divided into the anterior, lateral and posterior regions, then each region of both lungs was scanned with the probe perpendicular to the ribs or parallel to the Intercostal spaces.ResultsThe major results showed that: (1) the common LUS manifestation of PH includes lung consolidation, air bronchograms, fluid bronchograms, pleural effusion, shred signs, pleural line abnormality and B-lines, while fibrin deposition sign is a rare sign of PH. (2) Co-existing of lung consolidation with fluid bronchograms and pleural effusion is the specific sign of PH with a sensitivity of 81.0%, specificity of 98.4% and the positive predictive value (PPV) was 94.4%. (3) Fibrin deposition sign is an uncommon specific LUS sign of PH with a sensitivity 28.6%, specificity of 100% and the PPV was 100%. (4) Nine patients (21.4%) were diagnosed with PH based on ultrasound findings before oronasal bleeding. (5) The survival rate of infants with PH was 100% in this study.ConclusionLUS is helpful for the early diagnosis of neonatal PH and may therefore improve the prognosis. The lung consolidation with fluid bronchograms and pleural effusion as well as fibrin deposition sign are specific to diagnose PH by using LUS.

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“…Newborn clinical data included gestational age (week), birth weight (g), the severity of BPD, early-onset PH, 1-min Apgar score (A1), 5-min Apgar score (A5), meconium aspiration syndrome (MAS), amniotic fluid contamination, exclusive breastfeeding, neonatal respiratory distress syndrome (NRDS) more than II grades, ventilator-associated pneumonia [ 11 ], septicemia [ 12 ], necrotizing enterocolitis (NEC) requiring surgery, pulmonary hemorrhage [ 13 ], hemodynamically significant PDA [ 14 ], retinopathy of prematurity (ROP) more than II grades, small for gestational age (SGA), sex, age at initiated feeding (day), and time to achieve full enteral feeding (day).…”

Section: Introductionmentioning

confidence: 99%

A comprehensive study on machine learning models combining with oversampling for bronchopulmonary dysplasia-associated pulmonary hypertension in very preterm infants

Wang,

Huang,

Cao

et al. 2024

Respir Res

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Background Bronchopulmonary dysplasia-associated pulmonary hypertension (BPD-PH) remains a devastating clinical complication seriously affecting the therapeutic outcome of preterm infants. Hence, early prevention and timely diagnosis prior to pathological change is the key to reducing morbidity and improving prognosis. Our primary objective is to utilize machine learning techniques to build predictive models that could accurately identify BPD infants at risk of developing PH. Methods The data utilized in this study were collected from neonatology departments of four tertiary-level hospitals in China. To address the issue of imbalanced data, oversampling algorithms synthetic minority over-sampling technique (SMOTE) was applied to improve the model. Results Seven hundred sixty one clinical records were collected in our study. Following data pre-processing and feature selection, 5 of the 46 features were used to build models, including duration of invasive respiratory support (day), the severity of BPD, ventilator-associated pneumonia, pulmonary hemorrhage, and early-onset PH. Four machine learning models were applied to predictive learning, and after comprehensive selection a model was ultimately selected. The model achieved 93.8% sensitivity, 85.0% accuracy, and 0.933 AUC. A score of the logistic regression formula greater than 0 was identified as a warning sign of BPD-PH. Conclusions We comprehensively compared different machine learning models and ultimately obtained a good prognosis model which was sufficient to support pediatric clinicians to make early diagnosis and formulate a better treatment plan for pediatric patients with BPD-PH.

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Pulmonary Hemorrhage in the Neonate

Cited by 14 publications

References 35 publications

Dose pulmonary hemorrhage increase the risk of bronchopulmonary dysplasia in very low birth weight infants?

Dose pulmonary hemorrhage increase the risk of bronchopulmonary dysplasia in very low birth weight infants?

The specific signs of lung ultrasound to diagnose pulmonary hemorrhage of the newborns: Evidence from a multicenter retrospective case-control study

A comprehensive study on machine learning models combining with oversampling for bronchopulmonary dysplasia-associated pulmonary hypertension in very preterm infants

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