Pulmonary Hemodynamic Effects of Dipyridamole Infusion in Patients with Normal and Elevated Pulmonary Artery Systolic Pressure Receiving PB127

Main, Michael L.; Ehlgen, Alexander; Coggins, Tina R.; Morris, Becky A.; Lanza, Pam; Tremblay, Thomas; Schiller, Nelson B.; Goldman, Jonathan H.

doi:10.1016/j.echo.2006.03.006

Cited by 6 publications

(3 citation statements)

References 14 publications

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“…3 Because such MBs are not ideal for clinical use due to the complex carbohydrate chemistry 4 and possible immunogenicity, 5,6 we sought to develop an ischemic memory UMI probe that could be more readily extended to humans. We hypothesized that UMI for ischemic memory could be achieved using a double-layer MB contrast agent previously used safely in humans, 7,8 now conjugated to an E-selectin-specific 12-mer synthetic peptide on the surface.…”

mentioning

confidence: 99%

Ultrasound Detection of Myocardial Ischemic Memory Using an E-Selectin Targeting Peptide Amenable to Human Application

et al. 2014

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Vascular endothelial leukocyte adhesion molecules, such as E-selectin, are acutely upregulated in myocardial ischemia/reperfusion and are thus "ischemic memory" biomarkers for recent cardiac ischemia. We sought to develop an ultrasound molecular imaging agent composed of microbubbles (MBs) targeted to E-selectin to enable the differential diagnosis of myocardial ischemia in patients presenting with chest pain of unclear etiology. Biodegradable polymer MBs were prepared bearing a peptide with specific human E-selectin affinity (MBESEL). Control MBs had scrambled peptide (MBCTL) or nonspecific IgG (MBIgG). MBESEL adhesion to activated rat endothelial cells (ECs) was confirmed in vitro in a flow system and in vivo with intravital microscopy of rat cremaster microcirculation. Ultrasound molecular imaging of recent myocardial ischemia was performed in rats 4 hours after transient (15 minutes) coronary occlusion. MBESEL adhesion was higher to inflamed versus normal ECs in vitro; there was no difference in MBCTL or MBIgG adhesion to inflamed versus normal ECs. There was greater adhesion of MBESEL to inflamed versus noninflamed microcirculation and minimal adhesion of MBCTL or MBIgG under any condition. Ultrasound imaging after injection of MBSEL demonstrated persistent contrast enhancement of the previously ischemic region. Videointensity in postischemic myocardium after MBESEL was higher than that in the nonischemic bed (11.6 ± 2.7 dB vs 3.6 ± 0.8 dB, p < .02) and higher than that after MBCTL (4.0 ± 1.0 dB, p < .03) or MBIgG (1.7 ± 0.1 dB, p < .03). MBs targeted to E-selectin via a short synthetic peptide with human E-selectin binding affinity enables echocardiographic detection of recent ischemia, setting the stage for clinical myocardial ischemic memory imaging to identify acute coronary syndromes.

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mentioning

confidence: 99%

Ultrasound Detection of Myocardial Ischemic Memory Using an E-Selectin Targeting Peptide Amenable to Human Application

et al. 2014

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“…In 1996, Point Biomedical corp. (san carlos, ca) was established, which marketed several polymer Ucas, such as PB127. PB127 (cardIosphere) was tested in different clinical trials [95], [96]. However, no approval by the Fda followed and in 2008, Point Biomedical had to cease its activities.…”

Section: Hard-shelled Bubble Modelsmentioning

confidence: 99%

20 years of ultrasound contrast agent modeling

Faez

Emmer

Kooiman

et al. 2013

IEEE Trans. Ultrason., Ferroelect., Freq. Contr.

129

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The merits of ultrasound contrast agents (UCAs) were already known in the 1960s. It was, however, not until the 1990s that UCAs were clinically approved and marketed. In these years, it was realized that the UCAs are not just efficient ultrasound scatterers, but that their main constituent, the coated gas microbubble, acts as a nonlinear resonator and, as such, is capable of generating harmonic energy. Subharmonic, ultraharmonic, and higher harmonic frequencies of the transmitted ultrasound frequency have been reported. This opened up new prospects for their use and several detection strategies have been developed to exploit this harmonic energy to discriminate the contrast bubbles from surrounding tissue. This insight created a need for tools to study coated bubble behavior in an ultrasound field and the first models were developed. Since then, 20 years have elapsed, in which a broad range of UCAs and UCA models have been developed. Although the models have helped in understanding the responses of coated bubbles, the influence of the coating has not been fully elucidated to date and UCA models are still being improved. The aim of this review paper is to offer an overview in these developments and indicate future directions for research.

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“…Main et al [47] described alteration in pulmonary circulation hemodynamics after the intravenous injection of agent PB127 and dipiridamole, in patients who had elevated and normal pulmonary artery systolic pressure. They concluded that PB127 infusion does not alter pulmonary hemodynamics A recent study [48] has analyzed short and long term outcomes in patients with elevated right ventricular systolic pressure (a non-invasive surrogate of pulmonary artery systolic pressure) who underwent stress echocardiography with or without the implementation of contrast agents.…”

Section: Clinical Datamentioning

confidence: 99%

Ultrasound Contrast Agents: Updated Data on Safety Profile

Aggeli

Felekos²,

Siasos³

et al. 2012

CPD

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Contrast echocardiography represents a major technological advancement in the constantly evolving field of cardiovascular imaging. Over the last twenty years numerous studies have been published, illustrating the incremental value of contrast implementation into a variety of clinical scenarios. However, serious concerns have been raised about contrast safety profile, mainly based on postmarketing observational data and several animal studies. The latter have investigated contrast bio effects under experimental conditions that are not consistent with daily clinical practice. On the other hand, numerous clinical trials with large registries have proven otherwise. Not only contrast agents are efficient, but they also demonstrate a remarkable safety profile. So the question is: should we fear contrast utilization or should we consider them as an adjunctive and indispensable clinical tool for daily bedside practice?

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Pulmonary Hemodynamic Effects of Dipyridamole Infusion in Patients with Normal and Elevated Pulmonary Artery Systolic Pressure Receiving PB127

Cited by 6 publications

References 14 publications

Ultrasound Detection of Myocardial Ischemic Memory Using an E-Selectin Targeting Peptide Amenable to Human Application

Ultrasound Detection of Myocardial Ischemic Memory Using an E-Selectin Targeting Peptide Amenable to Human Application

20 years of ultrasound contrast agent modeling

Ultrasound Contrast Agents: Updated Data on Safety Profile

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