Pulmonary Ground-Glass Opacity (GGO) Lesions–Large Size and a History of Lung Cancer are Risk Factors for Growth

Hiramatsu, Masayuki; Inagaki, Takuya; Inagaki, Tomoya; Matsui, Yoshio; Satoh, Yukitoshi; Okumura, Sakae; Ishikawa, Yuichi; Miyaoka, Etsuo; Nakagawa, Ken

doi:10.1097/jto.0b013e318189f526

Cited by 138 publications

(119 citation statements)

References 23 publications

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“…Thus, the majority of pure GGNs remained stable on later follow-up. On the other hand, in study populations, which included patients with a history of malignancy, a much higher proportion (15%-58%) of pure GGNs showed interval growth (42,43). These studies indicate that a history of past malignancy is a risk factor for nodule growth.…”

Section: Natural Clinical Course Of Subsolid Nodulesmentioning

confidence: 90%

See 1 more Smart Citation

Pulmonary subsolid nodules: what radiologists need to know about the imaging features and management strategy

Kim¹,

Park²,

Koh³

et al. 2013

Diagn Interv Radiol

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Section: Natural Clinical Course Of Subsolid Nodulesmentioning

confidence: 90%

“…For part-solid GGNs, growth was observed in 40%-46.2% after a mean or median follow-up period of 35-59 months (41,42). In a study population from the Multicentric Italian Lung Detection (MILD) project, Silva et al (41) disclosed the natural course of part-solid GGNs with a solid component smaller than 5 mm.…”

Section: Natural Clinical Course Of Subsolid Nodulesmentioning

confidence: 99%

Pulmonary subsolid nodules: what radiologists need to know about the imaging features and management strategy

Kim¹,

Park²,

Koh³

et al. 2013

Diagn Interv Radiol

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“…Although the natural history and growth rate of the various lesions along the adenocarcinoma spectrum have been previously studied (6,7,(22)(23)(24)(25), to the best of our knowledge, there are no published studies in which the volume and mass changes of pulmonary adenocarcinomas with GGOs (and their respective DTs) have been investigated using 3D software for each CT performed throughout follow-up (not just the baseline and last CT scan). Therefore, this study aimed to explore the growth pattern and rate of a group of pulmonary adenocarcinomas appearing as GGOs that were retrospectively analyzed with 3D commercial software to further understand their natural volumetric behavior.…”

mentioning

confidence: 99%

Pulmonary adenocarcinomas presenting as ground-glass opacities on multidetector CT: three-dimensional computer-assisted analysis of growth pattern and doubling time

Borghesi

Farina²,

Michelini³

et al. 2016

Diagn Interv Radiol

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We aimed to evaluate the growth pattern and doubling time (DT) of pulmonary adenocarcinomas exhibiting ground-glass opacities (GGOs) on multidetector computed tomography (CT). METHODS The growth pattern and DT of 22 pulmonary adenocarcinomas exhibiting GGOs were retrospectively analyzed using three-dimensional semiautomatic software. Analysis of each lesion was based on calculations of volume and mass changes and their respective DTs throughout CT follow- up. Three-dimensional segmentation was performed by a single radiologist on each CT scan. The same observer and another radiologist independently repeated the segmentation at the baseline and the last CT scan to determine the variability of the measurements. The relationships among DTs, histopathology, and initial CT features of the lesions were also analyzed. RESULTS Pulmonary adenocarcinomas presenting as GGOs exhibited different growth patterns: some lesions grew rapidly and some grew slowly, whereas others alternated between periods of growth, stability, or shrinkage. A significant increase in volume and mass that exceeded the coefficient of repeatability of interobserver variability was observed in 72.7% and 84.2% of GGOs, respectively. The volume-DTs and mass-DTs were heterogeneous throughout the follow-up CT scan (range, -4293 to 21928 and -3113 to 17020 days, respectively), and their intra- and interobserver variabilities were moderately high. The volume-DTs and mass-DTs were not correlated with the initial CT features of GGOs; however, they were significantly shorter in invasive adenocarcinomas (P = 0.002 and P = 0.001, respectively). CONCLUSION Pulmonary adenocarcinomas exhibiting GGOs show heterogeneous growth patterns with a trend toward a progressive increase in size. DTs may be useful for predicting tumor aggressiveness

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“…Because biopsy of these lesions is sometimes difficult, these slowgrowing small GGO lesions are currently considered to be candidates for observation rather than for definitive diagnosis or treatment [11]. Hiramatsu et al reported that some independent factors affecting the growth rates of GGO lesions include the initial tumor size and the history of lung cancer [8]. However, in our case, the mean doubling time of multiple GGO lesions was 402 days, and the shortest doubling time was 255 days, being shorter than that reported in the past.…”

Section: Discussionmentioning

confidence: 99%

Multiple Ground-Glass Opacities with Different Growth Rates in the Same Lobe of the Lung during the Follow-Up after the Resection of Pulmonary Adenocarcinoma: A Case Report

Yukawa¹,

Shimizu²,

Hirami³

et al. 2014

CRCM

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The patient, a 77-year-old male, underwent right middle lobectomy for adenocarcinoma of the lung, pT1aN0M0, in November 2007. In November 2008, chest CT revealed two ground-glass opacities (GGOs) in the right lower lobe. In October 2009, both of these GGOs had increased in size, and three new GGOs were found. In July 2011, all of the five GGOs had increased in size and three new GGOs were found yet again. Right lower lobe S6 segmentectomy was performed on September 6, 2011, and histopathological examination revealed eight pulmonary adenocarcinomas in the right S6; all of them classified as pl0, ly0, v0, pT1aN0M0. Among the eight lesions, the doubling times of five were measured during the follow-up course, and the mean doubling time was 402 days. The mean doubling time of the lesions showing high c-erbB2 expression was significantly lesser than that of the lesions showing low c-erbB2 expression (273 days vs. 488 days, p = 0.047). Despite being localized GGOs that had arisen in the same individual, it should be noted that the growth rate of the GGO lesions may vary according to the expression level of a molecular markers, and some GGO lesions may show rapid increase in size.

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Pulmonary Ground-Glass Opacity (GGO) Lesions–Large Size and a History of Lung Cancer are Risk Factors for Growth

Abstract: After initial management and 3 month follow-up, larger size (more than 10 mm) and a history of lung cancer are risk factors for GGO growth, and therefore should be considered when making a follow-up plan.

Cited by 138 publications

References 23 publications

Pulmonary subsolid nodules: what radiologists need to know about the imaging features and management strategy

Pulmonary subsolid nodules: what radiologists need to know about the imaging features and management strategy

Pulmonary adenocarcinomas presenting as ground-glass opacities on multidetector CT: three-dimensional computer-assisted analysis of growth pattern and doubling time

Multiple Ground-Glass Opacities with Different Growth Rates in the Same Lobe of the Lung during the Follow-Up after the Resection of Pulmonary Adenocarcinoma: A Case Report

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