Pulmonary Giant Cell Carcinoma Associated With Pseudomyxoma Peritonei

Abstract

Pulmonary giant cell carcinoma is a rare subtype of sarcomatoid carcinoma. Pseudomyxoma peritonei (PMP) is a rare condition in which gelatinous material accumulates within the peritoneal cavity. It is believed PMP arises from a primary appendiceal mucinous neoplasm that perforates the gut, causing mucinous ascites. There are sporadic reports of PMP associated with neoplasms of other organs, rarely the lung. Here, we report on a 60-year-old woman with pulmonary giant cell carcinoma associated with PMP. She presented with progressive dyspnea and abdominal distention. Abdominal computed tomography revealed moderately dense ascites without an obvious mass. Chest computed tomography revealed a large, solitary right lower-lobe lung mass. She underwent transbronchial fine-needle aspiration of the mass, and was diagnosed with pulmonary giant cell carcinoma. The ascites showed scattered malignant cells in a background of mucin, confirming PMP. To our knowledge, this is the first report of pulmonary giant cell carcinoma associated with PMP.

Recurrence and metastasis of pseudomyxoma peritonei: A rare case report

“…This condition is characterized by the dissemination of tumorous cells within the peritoneal cavity, leading to the production of mucinous ascites [2] . The majority of PMP cases originate from ruptured appendiceal neoplasms, though a minority stem from mucinous tumors of the ovary, fallopian tube, urachus, colorectum, gallbladder, stomach, pancreas, lung, and breast [3] , [4] , [5] , [6] , [7] , [8] . Metastasis of PMP beyond the peritoneal cavity via hematogenous or lymphatic routes is rare.…”

Pseudomyxoma peritonei of a mature ovarian teratoma caused by mismatch repair deficiency in a patient with Lynch syndrome: a case report

“…Patients with PMP usually suffer from abdominal distension, change of body weight, abdominal or pelvic pain, and/or digestive disorder by the accumulation of ascites and/or the progression of disseminated lesion. Tumour cells of PMP are most frequently derived from rupture of appendiceal neoplasms, but occasionally from the tumours in other organs including the ovary [1, 3], fallopian tube [4], urachus [1, 5], colorectum [1, 6], gallbladder [7], stomach [8], pancreas [1, 9], lung [10] and breast [11]. The average onset of the disease is reportedly from 49 to 62 years old, which is earlier than other abdominal malignancies [1, 12].…”