Pulmonary Functions and Oxidative Stress Biomarkers Among Silica-Exposed Foundry Workers

Abstract

This work showed that radiological abnormalities and reduction in ventilatory functions among silica-exposed workers was mediated through oxidative stress, evidenced by increased serum MDA level, indicating lipid peroxidation, and increased serum 8-HdG indicating oxidative DNA damage. Consumption of GPx enzyme occured to balance the oxidative effects of the free radicals.

Urinary Silica Levels Might Reflect External Contamination of Exposed Workers

“…I have read with interest the article from Hussein et al Entitled Pulmonary Functions and Oxidative Stress Biomarkers Among Silica-Exposed Foundry Workers 1 . I was intrigued by the use of urinary silica as a biomarker for workers exposed to silica.…”