Pulmonary functional assessment: longitudinal study after treatment of pulmonary tuberculosis

Nishi, Marina Pires; Mancuzo, Eliane Viana; Sulmonett, Nara; Almeida, Isabela Neves de; Cesar, Aina Liz Alves; Miranda, Silvana Spíndola de

doi:10.1590/s1678-9946202163065

Cited by 6 publications

(3 citation statements)

References 29 publications

(51 reference statements)

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“…Impaired DL CO was associated with an increasing number of bronchiectatic lobes 20 . The mean value of DL CO in patients with pulmonary sequelae of tuberculosis was 74.1–78.8% 21 , 22 . Therefore, it would be better to understand the natural course of COPD with heterogeneous features by using DL CO as a holistic index of parenchymal destruction rather than the extent of emphysema.…”

Section: Discussionmentioning

confidence: 93%

Diffusing capacity as an independent predictor of acute exacerbations in chronic obstructive pulmonary disease

Park,

Lee,

Lee

et al. 2024

Sci Rep

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A weak correlation between diffusing capacity of the lung for carbon monoxide (DLCO) and emphysema has been reported. This study investigated whether impaired DLCO in chronic obstructive pulmonary disease (COPD) is associated with increased risk of acute exacerbation independent of the presence or extent of emphysema. This retrospective cohort study included patients with COPD between January 2004 and December 2019. The participants were divided into four groups based on visually detected emphysema and impaired DLCO. Among 597 patients with COPD, 8.5% had no emphysema and impaired DLCO whereas 36.3% had emphysema without impaired DLCO. Among the four groups, patients with impaired DLCO and emphysema showed a higher risk of moderate-to-severe or severe exacerbation than those with normal DLCO. Impaired DLCO was an independent risk factor for severe exacerbation (hazard ratio, 1.524 [95% confidence interval 1.121–2.072]), whereas the presence of emphysema was not. The risk of moderate-to-severe or severe exacerbation increases with the severity of impaired DLCO. After propensity-score matching for the extent of emphysema, impaired DLCO was significantly associated with a higher risk of moderate-to-severe (p = 0.041) or severe exacerbation (p = 0.020). In patients with COPD and heterogeneous parenchymal abnormalities, DLCO can be considered an independent biomarker of acute exacerbation.

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Section: Discussionmentioning

confidence: 93%

Diffusing capacity as an independent predictor of acute exacerbations in chronic obstructive pulmonary disease

Park,

Lee,

Lee

et al. 2024

Sci Rep

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“…China’s tuberculosis control program has been implemented for many years, and a large number of TB patients have been discovered and treated, which effectively curbed the trend of tuberculosis transmission. 23 However, due to the non-standard use of anti-tuberculosis drugs, there have been more and more drug resistant tuberculosis cases in China. 23 A previous study showed that China had 120 thousand new cases of MDR-TB annually, accounting for a quarter all over the world.…”

Section: Discussionmentioning

confidence: 99%

“… 23 However, due to the non-standard use of anti-tuberculosis drugs, there have been more and more drug resistant tuberculosis cases in China. 23 A previous study showed that China had 120 thousand new cases of MDR-TB annually, accounting for a quarter all over the world. 24 At present, the pathogenesis of MDR-TB is not clear, and risk factors affecting the occurrence of MDR-TB are varied in different countries and regions.…”

Section: Discussionmentioning

confidence: 99%

Analysis of Clinical Characteristics and Risk Factors for Drug Resistance in Newly-Treated Patients with Pulmonary Tuberculosis Complicated with Chronic Obstructive Pulmonary Disease

Ma¹,

Gao²

2022

IDR

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Objective To analyze the clinical characteristics and risk factors of drug resistance of newly-treated chronic obstructive pulmonary disease (COPD) complicated pulmonary tuberculosis (PTB). Methods A total of 489 newly-treated PTB patients admitted to Beijing Geriatric hospital were retrospectively enrolled in this study. Of these, 138 patients with COPD were allocated to the study group, and the remaining 351 patients without COPD were allocated to the control group. The baseline information, clinical characteristics of PTB and drug resistance of Mycobacterium tuberculosis were compared between the two groups. Logistic regression was used to explore the correlation between drug resistance and COPD complications. Results Patients complicated with COPD had a higher proportion of respiratory failure, cough, fever and night sweats, chest short breath, and emaciation between the study group and the control group ( P <0.05). In terms of medical history, patients complicated with COPD also had a higher proportion of childhood TB history, cough, tuberculosis exposure rate, dust exposure rate, and malnutrition ( P <0.05). There were significantly more patients with pulmonary cavities and a delayed diagnosis of TB in the study group than in the control group ( P <0.05). The single drug resistance rates of isoniazid, ethambutol, rifampicin, pyrazinamide, and rifapentine, and drug resistance with any two or more drugs in the study group were significantly higher than those in the control group ( P <0.05). Multivariate Logistic regression analysis showed that smoking, extrapulmonary tuberculosis, tuberculosis exposure history, malnutrition, pulmonary cavity, and delayed TB diagnosis were risk factors for drug resistance in newly-treated COPD complicated PTB patients. Conclusion The symptoms of COPD complicated PTB were more serious. Smoking history, extrapulmonary tuberculosis, tuberculosis exposure history, malnutrition, pulmonary cavity, and delayed diagnosis of tuberculosis were risk factors for TB resistance in these patients.

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Residual respiratory disability after successful treatment of pulmonary tuberculosis: a systematic review and meta-analysis

et al. 2023

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Pulmonary functional assessment: longitudinal study after treatment of pulmonary tuberculosis

Cited by 6 publications

References 29 publications

Diffusing capacity as an independent predictor of acute exacerbations in chronic obstructive pulmonary disease

Diffusing capacity as an independent predictor of acute exacerbations in chronic obstructive pulmonary disease

Analysis of Clinical Characteristics and Risk Factors for Drug Resistance in Newly-Treated Patients with Pulmonary Tuberculosis Complicated with Chronic Obstructive Pulmonary Disease

Residual respiratory disability after successful treatment of pulmonary tuberculosis: a systematic review and meta-analysis

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