Pulmonary function with acute loss of excess lung water by hemodialysis in patients with chronic uremia

Zidulka, A.; Despas, P.; Milic–Emili, J.; Anthonisen, N. R.

doi:10.1016/0002-9343(73)90161-7

Cited by 58 publications

(23 citation statements)

References 23 publications

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“…The initial signs of restrictive pattern from this study were in accordance with Zidulka et al [8]. They reported that uremic patients on chronic HD had re striction as dominant functional impairment before HD with normal FEF25_75% and reduced lung volumes due to reversible airway closure and gas trapping at the lung bases; this was ascribed to the fluid accumu lation around the small airways.…”

Section: Discussionsupporting

confidence: 90%

“…Patients with anemia have low values of pulmonary diffusion capacity for carbon monoxide (DLCO) [5][6][7], Decreased DLCO has also been observed in pa tients on chronic hemodialysis (HD) and was ex plained by coexisting anemia [8]. Dinkara et al [6] re ported that a reduction of the hemoglobin (Hb) level by 10 g/l in anemic patients resulted in a 1% DLCO decrease.…”

Section: Introductionmentioning

confidence: 99%

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Effects of Hemodialysis and Anemia on Pulmonary Diffusing Capacity, Membrane Diffusing Capacity and Capillary Blood Volume in Uremic Patients

Dujić¹,

Tocilj

Ljutić³

et al. 1991

Respiration

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The study aimed at investigating pulmonary function in uremic patients, emphasizing the lung diffusing capacity for CO (DLCO) and its membrane and pulmonary capillary blood volume (Vc) components. The study sample comprised 25 uremic patients without clinical/radiological evidence of lung disease. They were enrolled in a chronic hemodialysis (HD) program and had anemia requiring transfusions. The subjects were tested for their lung function before and after both a first HD and a HD with blood transfusion (BT) that followed a few days later. After HD-induced removal of body fluid, and increase in pre-HD reduced forced vital capacity, alveolar volume and mid-expiratory flow rate (FEF_25-75%) was observed. HD-induced DLCO decrease (p < 0.005) was observed and was related to decreased Vc. The second HD with BT increased DLCO, due to partially normalized Hb. On average, a 7.2% DLCO increase corresponded to each 10-g/l Hb rise. In conclusion, (1) the beneficial effect of HD in uremic patients reverts the small-airway obstruction; (2) the lower values of DLCO in these patients are due to reduced Hb and HD causes further DLCO reduction via decrease of Vc, and (3) HD with BT still increases DLCO because improvement of Hb predominates

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Section: Discussionsupporting

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Effects of Hemodialysis and Anemia on Pulmonary Diffusing Capacity, Membrane Diffusing Capacity and Capillary Blood Volume in Uremic Patients

Dujić¹,

Tocilj

Ljutić³

et al. 1991

Respiration

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“…2). The meaning of this result is that dialysis reduces an impairment which may be a central depression (due to an electrolytic imbalance for example) or a lung failure like edema which is known to be reduced by dialysis [Zidulka et al, 1973]. Studying the ventilatory response to CCF, it appears that CRF and healthy sub jects have the same CO2 sensitivity ( fig.…”

Section: Discussionmentioning

confidence: 98%

Ventilatory and Occlusion Pressure Responses to Hypercapnia in Patients with Chronic Renal Failure

et al. 1984

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Little is known of the effect of chronic renal failure (CRF) on ventilatory regulation. In 38 subjects (19 healthy, 19 with CRF before and after dialysis), we performed measurements of ventilation (V_E) and occlusion pressure (P_0.1) while the subjects were breathing air and hypercapnic gas mixtures. The results have shown that (1) during air ventilation, CRF patients exhibited lower values of V_E and P_0.1, which returned to normal after dialysis; (2) during hypercapnic ventilation, CRF patients had the same response as healthy subjects for V_E but higher P_0.1 hemodialysis induced an upward shift of the CO₂ response curve in CRF patients. A twofold mechanism is probably involved: pulmonary edema, which reduces lung elasticity, and neuromuscular hypoexcitability, both implying a stronger central command.

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“…Haemo dialysis in itself is not followed by any change in VC [6]. An increase in VC was observed in patients with overt cardiac decompensation when a large volume of excess fluid was removed during dialysis [7]. We report here on serial measurements of VC in patients or chronic haemodialysis.…”

Section: Introductionmentioning

confidence: 87%

Serial Measurement of Vital Capacity in Patients on Chronic Haemodialysis

Robson¹,

Levin²,

Ravid³

1977

Nephron

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Serial measurements of vital capacity (VC) were performed on nine patients on chronic haemodialysis. In six patients the VC remained stable, they were all adequately dialysed and working full-time. Reduction of dialysis time in one of these patients brought about a gradual onset of left heart failure which was preceeded by a decline of VC. In the three remaining patients a decrease of VC preceeded the onset of heart failure, and a rise of VC values signified improvement of cardiac performance. Serial recordings of VC are recommended as a useful objective guide to evaluation and treatment of patients on haemodialysis.

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Pulmonary function with acute loss of excess lung water by hemodialysis in patients with chronic uremia

Cited by 58 publications

References 23 publications

Effects of Hemodialysis and Anemia on Pulmonary Diffusing Capacity, Membrane Diffusing Capacity and Capillary Blood Volume in Uremic Patients

Effects of Hemodialysis and Anemia on Pulmonary Diffusing Capacity, Membrane Diffusing Capacity and Capillary Blood Volume in Uremic Patients

Ventilatory and Occlusion Pressure Responses to Hypercapnia in Patients with Chronic Renal Failure

Serial Measurement of Vital Capacity in Patients on Chronic Haemodialysis

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