Pulmonary Function Tests for the Generalist: A Brief Review

Dempsey, Timothy; Scanlon, Paul D.

doi:10.1016/j.mayocp.2018.04.009

Cited by 58 publications

(51 citation statements)

References 17 publications

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“…The pulmonary function test (PFT) is affected by ventilation and airway obstruction (46,47). It helps the surgeon to comprehend the nature, severity, and reversibility of the lung disease and thus facilitates the prediction of surgical outcomes and pulmonary complications, as well as the selection of the appropriate type of surgery and its extent (48). The forced expiratory volume at 1 sec (FEV1) can independently predict the risk of lung resection.…”

Section: Preoperative Pulmonary Function Assessmentmentioning

confidence: 99%

Clinical guidelines on perioperative management strategies for enhanced recovery after lung surgery

Gao

Barello

Chen

et al. 2019

Transl Lung Cancer Res

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Section: Preoperative Pulmonary Function Assessmentmentioning

confidence: 99%

Clinical guidelines on perioperative management strategies for enhanced recovery after lung surgery

Gao

Barello

Chen

et al. 2019

Transl Lung Cancer Res

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“…Studies indicate poor sensitivity of the lung volume measurements for the diagnosis of IPF [5, 46]. Furthermore, the pulmonary function test in the clinic, such as spirometry, is influenced by many factors, such as neuromuscular disorders [47]. In our research, the flow rate, volume change and maximum pressure drop of the healthy model are significantly larger than that of the NSIP and IPF models.…”

Section: Discussionmentioning

confidence: 67%

Characterization of air flow and lung function in the pulmonary acinus by fluid-structure interaction in idiopathic interstitial pneumonias

Chen

Zhao

2019

PLoS ONE

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Background and objective The idiopathic interstitial pneumonias (IIPs) are diffuse parenchymal lung disorders that are associated with substantial morbidity and mortality. Early diagnosis and disease stratification of IIP patients are important because these are related with the treatment and prognosis. Idiopathic pulmonary fibrosis (IPF) and nonspecific interstitial pneumonia (NSIP) are two major distinctive pathologic patterns of pulmonary fibrosis. We researched the application of the fluid-structure interaction (FSI) to the respiratory system and compared the pulmonary acinus mechanics and functions in healthy and IIP models. Methods The human pulmonary alveolus is idealized by a three-dimensional honeycomb-like geometry, and a fluid-structure interaction analysis is performed to study the normal and diseased breathing mechanics. The computational domain consists of two generations of alveolar ducts within the pulmonary acinus, with alveolar geometries approximated as closely packed 14-sided polygons. Findings In a normal breathing cycle, the flow rate of the healthy model is significantly larger than that of the NSIP and IPF models. Similar trends are observed for the volume change and the maximum pressure drop. The flow rate and the volume change of the NSIP are almost the same as those of IPF. The maximum pressure drop of NSIP is 5.5% larger than that of IPF. There is a 47% decrease in the pulmonary acinus compliance for the NSIP and IPF compared with that of the healthy model. The acinus resistances of NSIP and IPF are higher than those of the healthy lung by 6.4~11.2%. In particular, the pulmonary acinus resistance of the NSIP lung is higher than that of the IPF lung by 4.5%. Conclusions Our study demonstrates the differences of air flow and lung function in the pulmonary acinus between the healthy and the IIP models. These changes in the lung are important considerations for early diagnosis and disease stratification in patients. Patient-based geometry can to be included in the computational models in future studies.

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“…Furthermore, 34% of respondents reported undergoing a "pulmonary function test" which measures the adequacy of lung function. Comparatively in the civilian setting, pulmonary function tests are mainly reserved for adults over age 55, asthma patients, and those with chronic lung diseases" [15]. See "Appendix A (Table A1)" for additional "demographics" [16,17].…”

Section: Demographicsmentioning

confidence: 99%

A Pilot Study of Airborne Hazards and Other Toxic Exposures in Iraq War Veterans

Poisson

Boucher

Selby

et al. 2020

IJERPH

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During their deployment to Iraq in support of Operation Iraqi Freedom (OIF), many Veterans were exposed to a wide array of toxic substances and psychologic stressors, most notably airborne/environmental pollutants from open burn pits. Service members do not deploy whilst unhealthy, but often they return with a multitude of acute and chronic symptoms, some of which only begin to manifest years after their deployment. Our findings, while preliminary in nature, suggest that Iraq War Veterans who participated in our survey reported a decrease in overall physical fitness and increased respiratory clinical symptoms compared with pre-deployment periods. The objective of this report is to provide information that will benefit how combat Veterans are cared for post-deployment. Strategies for a wider and more comprehensive assessment and medical screening process post-deployment are recommended.

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Pulmonary Function Tests for the Generalist: A Brief Review

Cited by 58 publications

References 17 publications

Clinical guidelines on perioperative management strategies for enhanced recovery after lung surgery

Clinical guidelines on perioperative management strategies for enhanced recovery after lung surgery

Characterization of air flow and lung function in the pulmonary acinus by fluid-structure interaction in idiopathic interstitial pneumonias

A Pilot Study of Airborne Hazards and Other Toxic Exposures in Iraq War Veterans

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