Pulmonary function test in patients with asthma and chronic obstructive pulmonary disease in conditions of impared carbohydrate metabolism

Abstract

Objective: To study the state of pulmonary function tests (PFTs) in patients having non-allergic variant of bronchial asthma (NABA) and chronic obstructive pulmonary disease (COPD) either particularly or in combination with diabetes mellitus type 2 (DM2) in the context of the effect of glycemic control on PFTs.Methods: Such groups of patients as patients having NABA (n=61), patients suffering NABA combined with DM2 (n=20), patients with COPD (n=55); and patients having diagnosed COPD combined with DM2 (n=12) were examined. The blood glucose level was determined by the hexokinase method, the level of glycated hemoglobin was measured using the immunoinhibition method. PFTs were evaluated using spirometry, bronchodilator test, and body plethysmography (MasterScreen SN5112116, CareFusion 234 GmbH).Results: Statistically significant decrease of VС, FVC, and an increase of Raw in the group of patients with a combination of NABA and DM2 compared with the group having NABA was observed. An increase of Raw in the group with a combination of COPD and DM2 in comparison with the group having COPD was observed. Moreover negative correlations between the parameters of PFTs in different groups and the degree of carbohydrate metabolism disorders were detected.Conclusions: PFT indexes of patients having obstructive pulmonary pathology on the background of carbohydrate metabolism disorder tend to decrease due to different factors, especially glication of proteins.