Pulmonary function of a paediatric cohort of patients with postinfectious bronchiolitis obliterans. A long term follow-up

Colom, Alejandro; Maffey, Alberto; Garcia‐Bournissen, Facundo; Teper, Alejandro

doi:10.1136/thoraxjnl-2014-205328

Cited by 69 publications

(102 citation statements)

References 28 publications

(28 reference statements)

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“…The lung function values in our cohort were within the range of published data [1,3,12] and were significantly impaired compared to those of the controls. The typical finding showed severe airflow obstruction with hyperinflation.…”

Section: Discussionsupporting

confidence: 52%

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Short-Term Variation of Lung Function and Airway Inflammation in Children and Adolescents with Bronchiolitis Obliterans

Eckrich

Herrmann

Voss

et al. 2016

Lung

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Section: Discussionsupporting

confidence: 52%

“…Clinical improvement during the disease process is somewhat attributed to the growth of the lungs and probably does not indicate regression of the pathology in the small airways [12,13]. In the majority of the published cohort studies, the overall prognosis of pulmonary function is poor.…”

Section: Introductionmentioning

confidence: 96%

Short-Term Variation of Lung Function and Airway Inflammation in Children and Adolescents with Bronchiolitis Obliterans

Eckrich

Herrmann

Voss

et al. 2016

Lung

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“…We read with great interest the paper by Colom et al 1 on pulmonary function of a paediatric cohort of patients with postinfectious bronchiolitis obliterans (BO). The authors concluded that pulmonary function remained severely impaired, showing an obstructive pattern with air trapping that slowly improved during childhood.…”

mentioning

confidence: 99%

Long-term lung function in postinfectious bronchiolitis obliterans

Rosewich

Eckrich

Zielen

2015

Thorax

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We read with great interest the paper by Colom et al 1 on pulmonary function of a paediatric cohort of patients with postinfectious bronchiolitis obliterans (BO). The authors concluded that pulmonary function remained severely impaired, showing an obstructive pattern with air trapping that slowly improved during childhood. In addition, they showed that nine (19%) patients developed thoracic deformity and seven (15.2%) bronchiectasis. On the first view, contrary to their findings, the FVC and FEV 1 increased by a mean of 11%/ year (95% CI 9.3% to 12.6%; p<0.0001) and 9%/year (95% CI 7.7% to 10.2%; p<0.0001) during childhood. This is quite difficult to understand since the authors did report the increase in lung volume in per cent only, but not in litre (L). Still, their findings are in good accordance with our findings in BO.We have recently characterised a cohort of 16 patients with BO aged median 13.3 ±4.6 years and measured their lung function prospectively over 24 months by 48 plethysmographies (three measurements in each patient). Of these patients, nine were in the period of growth.Our data confirmed that BO patients had significantly lower lung function (FVC, FEV 1 , FEV 1 /VC , MEF25 and increased residual volume (RV) and RV/ TLC (total lung capacity) values) as agematched controls.As shown in table 1, lung function of patients during growth period remained stable when expressed as predicted level of normal. But there was a significant increase in lung growth by a mean of FVC 0.3 L (14.1%) and FEV 1 0.19 L (13.3%) in the first year and FVC 0.08 L (3.98%) and FEV 1 0.03 L (2.09%) in the second year indicating that lung growth is clearly related to growth velocity. Therefore, to avoid misunderstanding, lung growth should not be expressed as mean increase per year during childhood as done in the abstract.

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“…We thank Drs Rosewich, Eckrich and Zielen for their interest and comments1 on our recent Thorax publication 2…”

mentioning

confidence: 99%

Authors’ response: Long-term lung function in postinfectious bronchiolitis obliterans

Colom

Maffey

Bournissen

et al. 2015

Thorax

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Pulmonary function of a paediatric cohort of patients with postinfectious bronchiolitis obliterans. A long term follow-up

Cited by 69 publications

References 28 publications

Short-Term Variation of Lung Function and Airway Inflammation in Children and Adolescents with Bronchiolitis Obliterans

Short-Term Variation of Lung Function and Airway Inflammation in Children and Adolescents with Bronchiolitis Obliterans

Long-term lung function in postinfectious bronchiolitis obliterans

Authors’ response: Long-term lung function in postinfectious bronchiolitis obliterans

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