Pulmonary function indices in children with sickle cell anemia in Enugu, south-east Nigeria

Achigbu, Kingsley Ihedioha; Odetunde, Odutola Israel; Chinawa, Josephat M; Achigbu, EO; Ikefuna, AN; Emodi, IJ; Ibe, BC

doi:10.15537/smj.2015.8.11525

Cited by 7 publications

(3 citation statements)

References 20 publications

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“…A Jamaican study found that young SCD adults with recurrent ACS had lower median FVC and FEV1 than those who had one or no ACS episodes, emphasizing the importance of identifying an effective method of preventing ACS episodes . Another Nigerian study reported that lung function indices were significantly lower in children and adolescents with SCA than matched controls with a hemoglobin genotype AA . Interestingly, Koumbourlis et al have shown that abnormal lung function may be present from infancy.…”

Section: Discussionmentioning

confidence: 99%

Surfactant protein D as a marker for pulmonary complications in pediatric patients with sickle cell disease: Relation to lung function tests

Tantawy

Adly

Ebeid

et al. 2019

Pediatric Pulmonology

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Background: Surfactant protein D (SP-D) is considered a candidate biomarker for lung integrity and for disease progression. Aim:We determined the level of SP-D in children and adolescents with SCD and assessed its possible relation to pulmonary complications and lung function.Methods: Serum SP-D levels were assessed in 50 SCD patients compared with 30 healthy controls. High-resolution computerized tomography (HRCT) of the chest was done. Forced vital capacity (FVC), forced expiratory volume in 1 s (FEV 1 ), FEV 1 /FVC% and forced expiratory flow rate during 25-75% of expiration (FEF25-75%) were determined.Results: SP-D was significantly higher in SCD patients than controls, particularly patients with sickle cell anemia than those with sickle β-thalassemia. SP-D levels were significantly associated with increasing severity of interstitial lung disease. The highest SP-D levels were observed among patients with restrictive lung disease followed by mixed type then obstructive lung disease. SP-D was positively correlated to HbS and serum ferritin while negatively correlated to duration of hydroxyurea treatment and parameters of pulmonary functions. ROC curve analysis revealed that SP-D cutoff value 720 ng/mL could significantly detect the presence of abnormal pulmonary function among SCD patients with 82% sensitivity and 88% specificity. Logistic regression analysis showed that SP-D is an independent factor related to abnormal pulmonary function in SCD.Conclusions: SP-D may be a promising biomarker for screening of SCD patients for risk of later pulmonary complications. K E Y W O R D S iron overload, pulmonary function tests, sickle cell disease, surfactant protein-D

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Section: Discussionmentioning

confidence: 99%

Surfactant protein D as a marker for pulmonary complications in pediatric patients with sickle cell disease: Relation to lung function tests

Tantawy

Adly

Ebeid

et al. 2019

Pediatric Pulmonology

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“…En el presente estudio sobre la función pulmonar en pacientes falcémicos, según la edad, el mayor número de casos estuvo representado por los pacientes de 10-15 años, equivalente a un 57%, lo que coincide con el estudio de Lunt et al 7 , según el cual la edad más frecuente fue de 6.6 a 18.5 años.…”

Section: Discussionunclassified

“…Lunt et al 7 reclutaron dos grupos de niños con edades entre 2 y 8 años, con un seguimiento entre 2 y 10 años. En ambos grupos de niños la función pulmonar se redujo significativamente, los episodios fueron más frecuentes durante el período de las crisis vasooclusivas.…”

Section: Introductionunclassified

Función pulmonar en falcémicos homocigotos de 5 a 15 años en consulta de hematología, Hospital Materno Infantil San Lorenzo De Los Mina agosto-octubre, 2015

Pantaleón

2018

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Se realizó un estudio descriptivo, retrospectivo, de corte transversal, para determinar la función pulmonar en falcémicos homocigotos de 5 a 15 años en la consulta de hematología del Hospital Materno Infantil San Lorenzo de Los Mina, durante el período agosto-octubre de 2015. De un total de 200 pacientes, 23 cumplieron con los criterios de inclusión. La edad más afectada es entre 10-15 años, equivalente a un 57%. El sexo masculino fue el más frecuente, con el 52%. La neumonía fue la enfermedad pulmonar previa más común, con un 48%. El 30% de los niños cursó con complicaciones, siendo el Síndrome Torácico Agudo el más reportado, con 6 casos (26%). Todos los pacientes tenían aplicada la vacuna antineumocócica. El 74% había sido transfundido. El tratamiento de sostén en el 70% de los casos era la hidroxiurea, y una combinación de hidroxiurea más terapia transfusional, en el 13% de los pacientes. Los niveles de hemoglobina más frecuentes correspondieron a la escala de 3-6 gramos y 18-27%, para un total de 11 casos. El patrón ventilatorio más frecuente fue el restrictivo en el 78% de los pacientes.

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Role of fractional exhaled nitric oxide in patients with sickle cell disease

Muñoz-Cutillas,

Bellón-Alonso,

Bardón-Cancho

et al. 2024

Anales de Pediatría (English Edition)

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Pulmonary function indices in children with sickle cell anemia in Enugu, south-east Nigeria

Cited by 7 publications

References 20 publications

Surfactant protein D as a marker for pulmonary complications in pediatric patients with sickle cell disease: Relation to lung function tests

Surfactant protein D as a marker for pulmonary complications in pediatric patients with sickle cell disease: Relation to lung function tests

Función pulmonar en falcémicos homocigotos de 5 a 15 años en consulta de hematología, Hospital Materno Infantil San Lorenzo De Los Mina agosto-octubre, 2015

Role of fractional exhaled nitric oxide in patients with sickle cell disease

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