Pulmonary Function in Paracoccidioidomycosis (South American Blastomycosis)

Lemle, A; Wanke, Bodo; Miranda, J. L.; Kropf, G; Mandel, Moyses Bernardo; Mandel, S R

doi:10.1378/chest.83.5.827

Cited by 16 publications

(14 citation statements)

References 5 publications

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“…In the chronic cases with a prolonged evolution the question arises of the relative contributions of PCM and COPD. In the comparative study of matched pairs of pure COPD and obstructive patients with PCM no difference between the means of unmatched patients was found, 53 suggesting that the infection adds little to COPD in terms of gas transfer, as was the case with spirometry.…”

Section: Pulmonary Function Testsmentioning

confidence: 94%

“…30 In a study of obstructive PCM patients matched according to seven parameters to non-PCM-COPD patients, no significant differences were found in the spirometric results, suggesting that the infection added nothing to underlying COPD. 53 Longitudinal studies will be needed to separate the influence of chronic bronchitis and PCM on spirometry.…”

Section: Pulmonary Function Testsmentioning

confidence: 99%

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Paracoccidioidomycosis

Bethlem¹,

Lemle²,

Bethlem³

et al. 1991

Semin Respir Crit Care Med

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Section: Pulmonary Function Testsmentioning

confidence: 94%

Section: Pulmonary Function Testsmentioning

confidence: 99%

Paracoccidioidomycosis

Bethlem¹,

Lemle²,

Bethlem³

et al. 1991

Semin Respir Crit Care Med

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“…However, in pulmonary parenchyma, even after treatment, P. brasiliensis induces chronic damage that leads to the development of lung fibrosis, which is most likely due to persistent antigenic stimulus that elicits a continuous inflammatory response (12). This process can result in a severe restriction of respiratory function and a decline in work capacity, thereby affecting patient quality of life (4,13,14). In fact, in more than 50% of cases in which the patient receives an adequate course of therapy, pulmonary fibrosis is radiographically documented at the end of the treatment period (15).…”

Section: Introductionmentioning

confidence: 99%

The lung in paracoccidioidomycosis: new insights into old problems

Costa¹,

Benard²,

Albuquerque³

et al. 2013

Clinics

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OBJECTIVES:Chronic paracoccidioidomycosis can diffusely affect the lungs. Even after antifungal therapy, patients may present with residual respiratory abnormalities due to fungus-induced lung fibrosis.METHODS:A cross-sectional analysis of 50 consecutive inactive, chronic paracoccidioidomycosis patients was performed using high resolution computed tomography, pulmonary function tests, ergospirometry, the six-minute walk test and health-related quality of life questionnaires.RESULTS:Radiological abnormalities were present in 98% of cases, the most frequent of which were architectural distortion (90%), reticulate and septal thickening (88%), centrilobular and paraseptal emphysema (84%) and parenchymal bands (74%). Patients typically presented with a mild obstructive disorder and a mild reduction in diffusion capacity with preserved exercise capacity, including VO2max and six-minute walking distance. Patient evaluation with the Saint-George Respiratory Questionnaire showed low impairment in the health-related quality of life, and the Medical Research Council questionnaire indicated a low dyspnea index. There were, however, patients with significant oxygen desaturation upon exercise that was associated with respiratory distress compared with the non-desaturated patients. The initial counterimmunoelectrophoresis of these patients was higher and lung emphysema was more prominent; however, there were no differences in the interstitial fibrotic tomographic abnormalities, tobacco exposure, functional responses, exercise capacity or quality of life.CONCLUSIONS:Inactive, chronic paracoccidioidomycosis patients show persistent and disseminated radiological abnormalities by high resolution computed tomography, short impairments in pulmonary function and low impacts on aerobic capacity and quality of life. However, there was a subset of individuals whose functional impairment was more severe. These patients present with higher initial serology and more severe emphysema, stressing the importance of adequate treatment associated with tobacco exposure cessation.

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“…The reduction of the appearance of radiological lesions, in general, does not follow pulmonary function recovery. 22,[59][60][61][62][63]…”

Section: Pulmonary Functionmentioning

confidence: 99%

Paracoccidioidomycosis disease (Lutz-Splendore-Almeida disease): Additional workup, differential diagnosis, cure control

Vasconcellos¹,

Ambrósio

Cristiane³

et al. 2014

Revista Médica De Minas Gerais

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The diagnosis of paracoccidioidomycosis requires epidemiological data to be available and for the presence of some more typical clinical manifestations.It requires complementary investigation with interventional methods, differential diagnosis of pathologies of great importance such as tuberculosis and lymphomas, and cure control. This update discusses the advances in these various areas, which include complementary investigation, differential diagnosis and cure control, pointing to development prospects that may help better define the best approach to this disease.

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Pulmonary Function in Paracoccidioidomycosis (South American Blastomycosis)

Cited by 16 publications

References 5 publications

Paracoccidioidomycosis

Paracoccidioidomycosis

The lung in paracoccidioidomycosis: new insights into old problems

Paracoccidioidomycosis disease (Lutz-Splendore-Almeida disease): Additional workup, differential diagnosis, cure control

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